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Due to major advances in understanding the biology and pathogenesis of the disease, the management of multiple myeloma is changing rapidly. New diagnostic and prognostic criteria have been introduced, and treatment options are multiplying with high-dose chemotherapy regimens, stem cell transplants, and the development of novel agents and immune-based strategies that target tumor cells directly. This book is aimed at the practitioner who is looking to put these advances into clinical context. It will serve as an up-to-date resource for treatment of myeloma and related disorders. Chapters are written by international authorities and contain color photos, diagrams, and algorithms outlining preferred treatment strategies. Relevant scientific information is integrated throughout, but the focus here is on providing practical therapeutic guidance for oncologists and hematologists caring for myeloma patients. The book covers all myeloma subtypes and related disorders, including amyloidosis, Waldenstrom macroglobulinemia, plasmacytoma, MGUS, and POEMS syndrome.

Multiple myeloma --- Paraproteinemia --- Treatment. --- Diagnosis.

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In 1947, Lerner and Watson showed that the cold-precipitable proteins in serum were gammaglobulins. These “cryoglobulins” were responsible for the corresponding clinical condition “cryoglobulinemia.” Meltzer and Franklin, in 1966, provided an accurate description of the typical clinical symptoms associated with cryoglobulinemia. Subsequent progress in this field was rather slow until the end of the 1980s, when cryoglobulinemia was definitively shown to be an extrahepatic manifestation of hepatitis C virus infection. The book is unique in its detailed presentation and fundamental approach. Highly qualified authors have contributed critical articles reviewing significant developments in our understanding of and therapeutic approach to HCV infection and cryoglobulinemia. The text is accompanied by striking color images and illustrations and highly informative tables. This comprehensive review of a systemic disease with a complex etiology is a valuable source of up-to-date, expert information not only for basic scientists and specialists in several disciplines but also for general practitioners as well as graduate and post-graduate students in clinical and medical research.

Cryoglobulinemia. --- Hepatitis C. --- Cryoglobulinemia --- Paraproteinemias --- Hemostatic Disorders --- Hepatitis C --- Flaviviridae --- Hepatitis, Chronic --- Vascular Diseases --- Medicine --- Hepatitis Viruses --- Blood Protein Disorders --- RNA Viruses --- Hepatitis --- Immunoproliferative Disorders --- Hepatitis, Viral, Human --- Health Occupations --- Cardiovascular Diseases --- Flaviviridae Infections --- Viruses --- Hemorrhagic Disorders --- Hematologic Diseases --- Virus Diseases --- Liver Diseases --- Diseases --- Vertebrate Viruses --- RNA Virus Infections --- Disciplines and Occupations --- Immune System Diseases --- Organisms --- Hemic and Lymphatic Diseases --- Digestive System Diseases --- Hepacivirus --- Hepatitis C, Chronic --- Pathology --- Vasculitis --- Health & Biological Sciences --- Urology & Nephrology --- Gastroenterology --- Cryogammaglobulinemia --- Hepatitis, Non-A, non-B --- Non-A, non-B hepatitis, Parenterally-transmitted --- Parenterally-transmitted non-A, non-B hepatitis --- Medicine. --- Internal medicine. --- Hepatology. --- Infectious diseases. --- Oncology. --- Rheumatology. --- Medicine & Public Health. --- Internal Medicine. --- Infectious Diseases. --- Flaviviral diseases --- Hepatitis, Viral --- Paraproteinemia --- Clinical medicine. --- Emerging infectious diseases. --- Oncology  . --- Tumors --- Internal medicine --- Connective tissues --- Joints --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Medicine, Internal --- Medicine, Clinical