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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Medicine --- Endocrinology --- Diabetes Mellitus --- cardiovascular disease --- Heart Failure --- Insulin --- pancreatic beta cells --- cardiomyocytes --- Diabetes Mellitus --- cardiovascular disease --- Heart Failure --- Insulin --- pancreatic beta cells --- cardiomyocytes

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

Diabetes Mellitus --- cardiovascular disease --- Heart Failure --- Insulin --- pancreatic beta cells --- cardiomyocytes

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Cell culture --- Cell culture. --- Cells, Cultured. --- Cellules cultivées --- Cellules --- Genetic Engineering. --- Ilots pancréatiques --- Islets of Langerhans --- Islets of Langerhans --- Langerhans, Îlots de --- Pancreatic beta cells --- Pancreatic beta cells. --- Pancréas --- Actes de congrès. --- Culture --- Congrès. --- Actes de congrès. --- Cytology. --- Secretion. --- Congrès. --- Cytologie --- Actes de congrès.

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Since the 1970s, there has been much discussion about the “glucoreceptor” and “substrate site” and which of these two is the dominant theory, but new findings on the glucose-sensing receptor have now shed new light on the “glucoreceptor theory.” This volume reviews recent advances concerning the glucose-sensing receptor in pancreatic beta-cells. The history of research into pancreatic beta-cells is long and complex; accordingly, the first chapters present the history of this field and explain the hypothesis of insulin secretion mechanisms: “glucoreceptor theory”. Subsequent chapters examine the function and activity of the glucose-sensing receptor in pancreatic beta-cells, such as identification, channel pathway, receptor signal and physiological role. Readers will gain a thorough understanding of the glucose-sensing receptor and glucose metabolism in pancreatic beta-cells, new insights into the pathophysiology of diabetes, and learn about new targets for the treatment of diabetes. .

Pancreatic beta cells. --- Medicine. --- Human physiology. --- Endocrinology. --- Biomedicine. --- Human Physiology. --- Internal medicine --- Hormones --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Beta cells --- Insulin-secreting cells --- Islands of Langerhans --- Endocrinología --- Fisiología humana --- Endocrinology .

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Diabetes Systems Biology provides senior undergraduate students and junior scientists, interested in diabetes systems biology, with a tool to learn more about the mathematical models and methods used to understand macroscopically and microscopically beta-cell behaviour in health and disease. The book introduces readers to the quantitative methods used to examine beta-cell dynamics, islet biology and architecture, as well as diabetes etiology and implications. The goal is to allow junior researchers in the fields of mathematical biology and biophysics to obtain a broad understanding of these quantitative methods, and guide them into taking the first steps into the field of diabetes systems biology. At the end of each chapter, several problem-solving exercises (that require both analytical and computational skills) are provided for the readers to help them become more proficient in this field. Part of Biophysical Society-IOP series.

Diabetes --- Systems biology --- Pancreatic beta cells --- Quantitative research --- Diabetes Mellitus. --- Systems Biology. --- Insulin-Secreting Cells. --- Evaluation Studies as Topic. --- Models, Theoretical. --- Biomedical engineering. --- SCIENCE / Life Sciences / Biophysics. --- Mathematical models. --- Mathematical models. --- Mathematical models. --- Methodology.