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Pancreas Transplantation --- Pancreatectomy --- Pancreatic Ducts --- surgery

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Pancreatitis --- Chronic Disease --- Pancreaticoduodenectomy --- Pancreatectomy --- Duodenum --- surgery --- methods --- methods --- surgery

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Pancreas --- Spleen --- Pancreatectomy. --- Splenectomy. --- Pancreas --- Spleen --- Pancreatectomy --- Splenectomy --- Pancréas --- Rate --- Pancréatectomie --- Splénectomie --- surgery. --- surgery. --- Surgery --- Surgery --- Chirurgie --- Chirurgie

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"The fourth edition of The Pancreas presents the most comprehensive and latest knowledge about the genetic and molecular biological basis of embryology, anatomy, physiology, pathophysiology, and pathology for all disorders of the pancreas. Compared to the first edition, published in 1998, the fourth edition contains three newly addressed diseases of the pancreas: autoimmune pancreatitis, benign and premalignant cystic neoplasms, and neuroendocrine tumors. The understanding of the functions and dysfunctions of the exocrine and endocrine pancreas is derived from increasingly profound molecular biological data on the actions of compounds in subcellular compartments and intracellular transcription pathways. In the respective chapters, the presentation of the inflammatory (acute or chronic) and oncological diseases (benign, premalignant, or advanced cancer) is based on molecular biological understanding of pathomorphological processes and clinical phenomena. In clinical pancreatology, new and improved technical devices enable the gastroenterologist and the gastrointestinal surgeon to identify lesions by high-resolution imaging techniques, imaging of metabolic processes, and intrapancreatic ductal morphologic processes. The molecular profiling of pancreatic ductal adenocarcinoma has provided a deeper understanding of the genomic alterations that drive pancreatic ductal adenocarcinoma, including driver genes, actionable mutations, copy number alterations, patterns of genomic aberrations, structural variations, and mutational signatures. These findings have transformed our biological genomic understanding, but are still of limited clinical utility. Significant progress has been made in understanding the molecular pathogenesis of pancreatic cancer and identification of various molecular subtypes. However, this improved understanding has unfortunately not yet led to relevant progress for the patient's cure, although survival gain after radical cancer resection in addition with adjuvant chemotherapy is significant for selected groups of patients"--

Pancreas --- Pancreas --- Pancreatic Diseases --- Pancreatic Diseases --- Pancreatectomy --- Pancreas --- Diseases --- Textbooks. --- Pathophysiology. --- physiopathology --- therapy --- methods --- physiology

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Pancreatic neoplasms include different pathological entities with variable biological behavior and different treatment modalities. Surgery and adjuvant therapy are the cornerstones of the therapeutic approach; however, even after radical resection, the majority of patients experience disease recurrence and the prognosis of pancreatic cancer remains dismal. A multimodal therapeutic approach, based on a combination of neoadjuvant therapy, chemotherapy, radiotherapy, immunotherapy and surgery, appears fundamental to improving the outcomes. This Special Issue of the Journal of Clinical Medicine, entitled “Recent Advances in Pancreatic Neoplasms”, focuses on possible new strategies to treat pancreatic neoplasms.

Medicine --- Oncology --- PIWI proteins --- PIWIL3 --- PIWIL4 --- pancreatic cancer --- EMT --- chemoresistance --- motility --- HNF4A --- survival --- pancreatic neuroendocrine neoplasm --- primary pancreatic carcinoid --- serotonin-secreting pancreatic tumour --- serotonin-producing pancreatic tumour --- neoadjuvant chemotherapy --- response --- carbohydrate antigen 19-9 --- fluorodeoxyglucose --- pancreatectomy --- positron emission tomography --- prognosis --- standardized uptake value --- Pancreatic ductal adenocarcinoma --- microRNAs --- pancreatic fistula --- pancreatic neoplasm --- renal cell carcinoma --- pancreatic neoplasms --- PET-CT scan --- pancreatic ductal adenocarcinoma --- pancreatic cancer prognosis --- completion total pancreatectomy --- pooled analysis --- recurrent pancreatic cancer --- repeated pancreatectomy --- pancreas --- neuropathy --- taxanes --- biomarker --- C-reactive protein to albumin ratio --- inflammation --- intraductal papillary mucinous neoplasm --- modified Glasgow prognostic score --- neutrophyl lymphocite ratio --- platelet-to-lymphocyte ratio --- robotic pancreatic surgery --- pancreato-gastrostomy --- low muscle mass --- sarcopenia --- pancreatic adenocarcinoma --- pancreatic surgery --- body composition --- PIWI proteins --- PIWIL3 --- PIWIL4 --- pancreatic cancer --- EMT --- chemoresistance --- motility --- HNF4A --- survival --- pancreatic neuroendocrine neoplasm --- primary pancreatic carcinoid --- serotonin-secreting pancreatic tumour --- serotonin-producing pancreatic tumour --- neoadjuvant chemotherapy --- response --- carbohydrate antigen 19-9 --- fluorodeoxyglucose --- pancreatectomy --- positron emission tomography --- prognosis --- standardized uptake value --- Pancreatic ductal adenocarcinoma --- microRNAs --- pancreatic fistula --- pancreatic neoplasm --- renal cell carcinoma --- pancreatic neoplasms --- PET-CT scan --- pancreatic ductal adenocarcinoma --- pancreatic cancer prognosis --- completion total pancreatectomy --- pooled analysis --- recurrent pancreatic cancer --- repeated pancreatectomy --- pancreas --- neuropathy --- taxanes --- biomarker --- C-reactive protein to albumin ratio --- inflammation --- intraductal papillary mucinous neoplasm --- modified Glasgow prognostic score --- neutrophyl lymphocite ratio --- platelet-to-lymphocyte ratio --- robotic pancreatic surgery --- pancreato-gastrostomy --- low muscle mass --- sarcopenia --- pancreatic adenocarcinoma --- pancreatic surgery --- body composition