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Activation of innate immune system underlies both pathological and physiological inflammatory responses and is critical for the host. Regulated innate immune response is thus essential not only for the elimination of invading pathogens but also for the restoration of tissue homeostasis. The innate immune system relies on the expression of families of highly conserved Pattern Recognition Receptors (PRRs) by specialised immune cells such as macrophages or dendritic cells. Engagement of PRRs by microbial or host-derived danger signals coordinates the cellular innate immune response. While some receptors such as Toll-like Receptors (TLRs) and C-type Lectin Receptors (CLRs) are membrane bound, others like the Retinoic-acid-Inducible Gene I (RIG-I)-Like Receptors (RLRs), Nucleotide-binding Oligomerization Domain (NOD)-Like Receptors (NLRs) and several DNA receptors (e.g. AIM2, cGAS) are expressed in the cytosol. Moreover, several molecules released by innate immune cells including complement proteins and members of the pentraxin family act as soluble PRRs. Activation of PRRs initiate specific signal transduction cascades, which lead to transcription and secretion of inflammatory mediators, thereby facilitating inflammation. Furthermore, some PRRs can form large oligomeric protein complexes called inflammasomes that instigate proteolytic maturation of members of the IL-1 family of cytokines, thereby driving inflammatory programmed cell death. Current research on immunomodulation is focused on understanding the fundamental mechanisms that control the activation and regulation of innate immune cell function. This includes exciting advances in understanding signals that can polarize innate immune cells into different functional states, for instance from a more inflammatory to a more tolerogenic profile. However, this response of innate immune cells critically depends on several intrinsic and extrinsic factors such as their own biological status and their microenvironmental context, respectively. For instance, it is known that the extracellular matrix or biomaterials can modulate macrophage behavior and that autophagy flux is a critical regulator of inflammation. Consistent with this, there has been an increase in the development of novel drugs and biomaterials aimed at inducing immunomodulatory responses in targeted innate immune cell populations to be used in the context of tissue regeneration, cancer, autoimmune disease etc. Thus, a thorough understanding of immunomodulatory mechanisms of innate immune cells will guide the development of novel therapeutic strategies aimed to control inflammation-mediated pathologies. In this Research Topic, we aim to highlight recent advances in our understanding of the fundamental mechanisms controlling activation of innate immune cells and document new strategies to study and manipulate their immunomodulation.

innate immunity --- PRRs --- immunomodulation --- pattern recognition --- macrophage polarization

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RNA viruses cause animal, human, and zoonotic diseases that affect millions of individuals, as is being exemplified by the devastating ongoing epidemic of the recently identified SARS-Cov-2. For years vaccines have had an enormous impact on overcoming the global burden of diseases. Nowadays, a vast number of different approaches, from purified inactivated and live attenuated viruses, nucleic acid (DNA or RNA) based candidates, virus-like particles, subunit elements, and recombinant viruses are been employed to combat viruses. However, for many of them efficient vaccines are not yet available. This will probably change dramatically with the current Covid-19 pandemic, as a vast variety of vaccinology approaches are being tested against it, with hundreds of candidates under development, dozens of them already in clinical trials, a fact that is breaking records in vaccine development and implementation. This is becoming possible thanks to the enormous work carried out during years to have the bases for a quick response, even against unknown pathogens, in an impressive short time. Here, results obtained with different vaccine´s methodological approaches against human (HIV, HCV, HRV) animal (PRRSV, PEDV, FMDV, VHSV) and zoonotic (RVF, WNV), RNA viruses are presented by field experts.

artificial protein --- polyepitope B- and T-cell HIV-1 immunogen --- epitopes of broadly neutralizing HIV-1 antibodies --- peptide mimic of discontinuous epitope --- immunogenicity --- birds --- vaccines --- West Nile virus --- flavivirus --- herd immunity --- porcine epidemic diarrhea virus --- RNA interference --- processivity factor --- intestine epithelial cells --- N gene --- rotavirus nanoparticle vaccine --- gnotobiotic pigs --- FMDV --- peptide vaccine --- single dose --- amount --- pig --- VHSV --- non-virion (NV) --- transcriptome profiling --- rainbow trout --- immune pathways --- Rift Valley fever virus (RVFV) --- modified vaccinia Ankara (MVA) --- cellular response --- neutralizing antibodies --- Gn Gc glycoproteins --- passive serum:virus transfer --- hepatitis C virus --- neutralising antibodies --- animal models --- immune responses --- PRRSV Mosaic T-cell DNA vaccine VACV --- PRRS --- cross protection --- heterologous virus challenge --- n/a

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Wood surface attributes can be established by examining its several different physical or chemical properties. Differences in the wood surfaces occur between the manufacturing and post-treatment processes as well. Understanding how their unique anisotropic molecular organization, chemical linkages, branching, and other molecular features govern micro- and macroscale accessibility is essential for coating and complex modification processes. It is therefore important for scientific as well as practical reasons to qualify and quantify the effects of wood surface treatments and modifications. Challenges still exist to fully understanding the effect of the numerous applied chemicals and the wide range of treatment processes on wood surfaces.

broiler --- thermal manipulation --- antioxidant --- heat stress --- cold stress --- Bovine Viral Diarrhea Virus --- RNA-Seq --- Transcriptome analysis --- Holstein cattle --- sheep --- intersex --- whole-genome resequencing --- copy number variation --- forming mechanism --- dairy cattle diseases --- innate immune system --- metabolic stress --- microbiome --- mastitis --- bovine mammary epithelial cells --- inflammatory cytokines --- NF-κB signaling --- PRRs --- TLRs --- Piemontese breed --- arthrogryposis --- macroglossia --- genetic model --- TLR3 --- TLR4 --- TLR7 --- foals --- immunostimulation --- gene expression --- bovine mastitis --- JAK-STAT pathway --- JAK2 --- STATs --- SOCS3 --- immunity --- milk production --- DNA methylation --- high-fat diet --- rabbits --- next generation sequencing --- transcriptomics --- bioinformatics --- genome editing --- disease resistance --- livestock --- dairy cattle --- teat-end hyperkeratosis --- udder health --- somatic cell --- genetic correlation --- selection response --- Holstein Friesian cattle --- mastitis resistance --- candidate genes --- SNP selection --- next-generation sequencing

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Plants possess a rather complex and efficient immune system. During their evolutionary history, plants have developed various defense strategies in order to recognize and distinguishing between self and non-self, and face pathogens and animal pests. Accordingly, to study the plant innate immunity represents a new frontier in the plant pathology and crop protection fields. This book is structured in 6 sections. The first part introduces some basic and general aspects of the plant innate immunity and crop protection. Sections 2–5 focus on fungal and oomycete diseases (section 2), bacterial and phytoplasma diseases (section 3), virus diseases (section 4), and insect pests (section 5), with a number of case studies and plant–pathogen/pest interactions. The last section deals with plant disease detection and control. The book aims to highlight new trends in these relevant areas of plant sciences, providing a global perspective that is useful for future and innovative ideas.

Bakraee --- tomato gray mold --- Citrus sinensis --- CDPKs --- salicylic acid --- calmodulin --- glycerol-3-phosphate --- biotic stress responses --- negative regulator --- rice blast --- metabolomics --- hydroperoxide lyase --- Bromoviridae --- induced defense responses --- leaf transcriptome --- calcium signature --- “Candidatus Liberibacter” --- garden impatiens --- Chilo suppressalis --- plant defence --- plant–virus interactions --- spectral distribution of light --- Magnaporthe oryzae --- plant-virus interaction --- biological control --- ultrastructure --- pathogenicity --- disease resistance --- Potato virus Y --- symbiosis --- N-hydroxypipecolic acid --- VaHAESA --- priming --- plant–microbe interactions --- systemic and local movement --- immunity --- CaWRKY40b --- plant protection products --- hypersensitive response --- cellulose synthase --- herbivore-induced defense response --- Macrosiphum euphorbiae --- RTNLB --- ISR --- RNA silencing --- herbivore-induced plant defenses --- disease management --- sustainable crop protection --- WRKY networks --- Camellia sinensis --- RNA-Seq --- transcriptional modulation --- ETI --- pathogenesis related-protein 2 --- cell wall --- basal defense --- candidate disease resistance gene --- MTI --- grapevine --- defense-related signaling pathways --- wounding --- ethylene --- CMLs --- Prune dwarf virus --- Arabidopsis thaliana --- SAR signalling --- innate immunity --- agrochemicals --- OsGID1 --- Nilaparvata lugens --- tobacco --- tomato leaf mold --- Solanum lycopersicum --- downy mildew --- pipecolic acid --- chemical elicitors --- bismerthiazol --- pre-conditioning --- gibberellin --- “Candidatus Phytoplasma” --- dieback --- CaWRKY22 --- microbiota --- Sogatella furcifera --- PTI --- SAR --- Bacillus subtilis --- PRRs --- aphid resistance --- methyl salicylate --- regurgitant --- Myzus persicae --- Agrobacterium --- Ectropis obliqua --- Capsicum annuum --- polyphenol oxidase --- plant proteases --- plant immunity --- jasmonic acid --- calcium --- light dependent signalling --- Ralstonia solanacearum --- proteomics --- plant defense response --- Arabidopsis --- Lasiodiplodia theobromae --- azelaic acid --- citrus decline disease --- New Guinea impatiens --- replication process --- rice --- mango --- ?-3 fatty acid desaturase --- Ralstonia Solanacearum --- food security --- iTRAQ --- mitogen-activated protein kinase 4

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Plants possess a rather complex and efficient immune system. During their evolutionary history, plants have developed various defense strategies in order to recognize and distinguishing between self and non-self, and face pathogens and animal pests. Accordingly, to study the plant innate immunity represents a new frontier in the plant pathology and crop protection fields. This book is structured in 6 sections. The first part introduces some basic and general aspects of the plant innate immunity and crop protection. Sections 2–5 focus on fungal and oomycete diseases (section 2), bacterial and phytoplasma diseases (section 3), virus diseases (section 4), and insect pests (section 5), with a number of case studies and plant–pathogen/pest interactions. The last section deals with plant disease detection and control. The book aims to highlight new trends in these relevant areas of plant sciences, providing a global perspective that is useful for future and innovative ideas.

Bakraee --- tomato gray mold --- Citrus sinensis --- CDPKs --- salicylic acid --- calmodulin --- glycerol-3-phosphate --- biotic stress responses --- negative regulator --- rice blast --- metabolomics --- hydroperoxide lyase --- Bromoviridae --- induced defense responses --- leaf transcriptome --- calcium signature --- “Candidatus Liberibacter” --- garden impatiens --- Chilo suppressalis --- plant defence --- plant–virus interactions --- spectral distribution of light --- Magnaporthe oryzae --- plant-virus interaction --- biological control --- ultrastructure --- pathogenicity --- disease resistance --- Potato virus Y --- symbiosis --- N-hydroxypipecolic acid --- VaHAESA --- priming --- plant–microbe interactions --- systemic and local movement --- immunity --- CaWRKY40b --- plant protection products --- hypersensitive response --- cellulose synthase --- herbivore-induced defense response --- Macrosiphum euphorbiae --- RTNLB --- ISR --- RNA silencing --- herbivore-induced plant defenses --- disease management --- sustainable crop protection --- WRKY networks --- Camellia sinensis --- RNA-Seq --- transcriptional modulation --- ETI --- pathogenesis related-protein 2 --- cell wall --- basal defense --- candidate disease resistance gene --- MTI --- grapevine --- defense-related signaling pathways --- wounding --- ethylene --- CMLs --- Prune dwarf virus --- Arabidopsis thaliana --- SAR signalling --- innate immunity --- agrochemicals --- OsGID1 --- Nilaparvata lugens --- tobacco --- tomato leaf mold --- Solanum lycopersicum --- downy mildew --- pipecolic acid --- chemical elicitors --- bismerthiazol --- pre-conditioning --- gibberellin --- “Candidatus Phytoplasma” --- dieback --- CaWRKY22 --- microbiota --- Sogatella furcifera --- PTI --- SAR --- Bacillus subtilis --- PRRs --- aphid resistance --- methyl salicylate --- regurgitant --- Myzus persicae --- Agrobacterium --- Ectropis obliqua --- Capsicum annuum --- polyphenol oxidase --- plant proteases --- plant immunity --- jasmonic acid --- calcium --- light dependent signalling --- Ralstonia solanacearum --- proteomics --- plant defense response --- Arabidopsis --- Lasiodiplodia theobromae --- azelaic acid --- citrus decline disease --- New Guinea impatiens --- replication process --- rice --- mango --- ?-3 fatty acid desaturase --- Ralstonia Solanacearum --- food security --- iTRAQ --- mitogen-activated protein kinase 4