Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Autoinflammation, as a relatively new field in clinical rheumatology, has gained an increasing importance in recent years. The number of identified entities and affected patients has gradually increased, and some of the involved pathways have already been identified. This progress allows a deeper understanding of closely linked diseases, namely, inflammasomopathies, interferonopathies, Relo-pathies, and proteasome associated syndromes. These insights have not only improved their classification but also helped to identify new treatment targets of pro-inflammatory cytokines, including IL-1ß, IL-6, interferon-, and TNF-alpha. Nevertheless, there is still a high medical need, especially in reliable outcome measures, for confirmation of data from controlled clinical trials and, finally, also for long-term experience from registers. This issue welcomes all types of papers on the broad spectrum of clinical characteristics, prognosis, pathophysiology, and treatment of autoinflammatory diseases. The goal of this Special Issue is to further raise awareness of autoinflammatory processes and to better separate them from well-established autoimmune diseases. It is clear that we have entered a new age in this complex field, linking rheumatology even closer to immunology.

gout --- febuxostat --- colchicine --- hepatotoxicity --- prophylaxis --- myositis --- inflammatory idiopathic myopathy --- dysphagia --- aspiration --- pneumonia --- immunoglobulin G4-related orbital disease (IgG4-ROD) --- orbital lymphoma (OL) --- computed tomography (CT) --- Hounsfield unit --- imaging --- autoinflammation --- arthritis --- CAPS --- FCAS --- MWS --- CINCA --- NOMID --- hearing loss --- urticarial-like rash --- autoinflammatory disease --- anti-IL-1 treatment --- rheumatoid arthritis --- synovitis --- neoplasms --- edema --- inflammation --- new genetic variant --- monogenic autoinflammatory syndrome --- diagnostic delay --- anakinra --- damage index --- genetic inheritance --- personalized therapy --- Interleukin-1 --- autoinflammatory diseases --- FMF --- coronavirus --- SARS-CoV-2 antibody response --- adult-onset Still’s disease --- autoinflammatory disorder --- systemic-onset juvenile idiopathic arthritis --- haemophagocytic lymphohistiocytosis --- macrophage activation syndrome --- IFN-γ --- JAK inhibitor --- proliferation --- DNA damage repair --- γH2AX --- PBMCs --- T lymphocytes --- proteasome --- autoimmune --- proteasome-associated autoinflammatory syndrome --- therapy --- IL-1 inhibitors --- NGS --- SURF --- spondyloarthritis --- human leukocyte antigen --- undifferentiated enthesitis and/or arthritis --- ASAS classification criteria --- clinical management --- canakinumab --- cytokines --- n/a --- adult-onset Still's disease

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Autoinflammation, as a relatively new field in clinical rheumatology, has gained an increasing importance in recent years. The number of identified entities and affected patients has gradually increased, and some of the involved pathways have already been identified. This progress allows a deeper understanding of closely linked diseases, namely, inflammasomopathies, interferonopathies, Relo-pathies, and proteasome associated syndromes. These insights have not only improved their classification but also helped to identify new treatment targets of pro-inflammatory cytokines, including IL-1ß, IL-6, interferon-, and TNF-alpha. Nevertheless, there is still a high medical need, especially in reliable outcome measures, for confirmation of data from controlled clinical trials and, finally, also for long-term experience from registers. This issue welcomes all types of papers on the broad spectrum of clinical characteristics, prognosis, pathophysiology, and treatment of autoinflammatory diseases. The goal of this Special Issue is to further raise awareness of autoinflammatory processes and to better separate them from well-established autoimmune diseases. It is clear that we have entered a new age in this complex field, linking rheumatology even closer to immunology.

Medicine --- gout --- febuxostat --- colchicine --- hepatotoxicity --- prophylaxis --- myositis --- inflammatory idiopathic myopathy --- dysphagia --- aspiration --- pneumonia --- immunoglobulin G4-related orbital disease (IgG4-ROD) --- orbital lymphoma (OL) --- computed tomography (CT) --- Hounsfield unit --- imaging --- autoinflammation --- arthritis --- CAPS --- FCAS --- MWS --- CINCA --- NOMID --- hearing loss --- urticarial-like rash --- autoinflammatory disease --- anti-IL-1 treatment --- rheumatoid arthritis --- synovitis --- neoplasms --- edema --- inflammation --- new genetic variant --- monogenic autoinflammatory syndrome --- diagnostic delay --- anakinra --- damage index --- genetic inheritance --- personalized therapy --- Interleukin-1 --- autoinflammatory diseases --- FMF --- coronavirus --- SARS-CoV-2 antibody response --- adult-onset Still's disease --- autoinflammatory disorder --- systemic-onset juvenile idiopathic arthritis --- haemophagocytic lymphohistiocytosis --- macrophage activation syndrome --- IFN-γ --- JAK inhibitor --- proliferation --- DNA damage repair --- γH2AX --- PBMCs --- T lymphocytes --- proteasome --- autoimmune --- proteasome-associated autoinflammatory syndrome --- therapy --- IL-1 inhibitors --- NGS --- SURF --- spondyloarthritis --- human leukocyte antigen --- undifferentiated enthesitis and/or arthritis --- ASAS classification criteria --- clinical management --- canakinumab --- cytokines

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Cardiac biomarkers such as troponins and natiuretic peptides have made a great impact on clinical decision making as well as improving our understanding of molecular mechanisms of different disease conditions. However, the biomarkers that are currently in use do not reflect all the multiple disease pathways that are involved in a broad spectrum of cardiac disease conditions ranging from acute coronary syndrome, to heart failure (and heart failure with preserved ejection fraction, HFpEF), to pulmonary hypertension or arrhythmias. In this Special Issue, we will provide an overview of the current developments in the field of biomarker research, beginning with research on molecular pathways and cellular communication (e.g., microRNA) up to the clinical use of biomarkers.

diet quality --- ceramides --- obesity --- cardiovascular risk --- healthy eating index --- carbohydrate antigen-125 --- heart failure --- inflammatory marker --- older women --- biomarker --- cardiometabolic disease --- epicardial adipose tissue --- epicardial fat --- epicardial fat volume --- microRNA --- thyroid-stimulating hormone --- cardiometabolic risks --- metabolic syndrome --- hypertension --- very low-density lipoprotein --- STIM1 --- SOCE --- atrial myopathy --- atrial fibrillation --- ejection fraction --- soluble urokinase-type plasminogen activator receptor (suPAR) --- growth differentiation factor 15 (GDF-15) --- heart-type fatty acid-binding protein (H-FABP) --- soluble suppression of tumorigenicity 2 (sST2) --- acute myocardial infarction --- biomarkers --- catestatin --- coronary artery disease --- heart failure decompensation --- left ventricular ejection fraction --- troponin --- NT-proBNP --- NYHA functional class --- GDF-15 --- cardiovascular surgery --- operative risk --- muscle wasting --- sarcopenia --- renal dysfunction --- chronic kidney disease --- aortic disease --- aneurysm --- miRNA --- TGF-β pathway --- KLF4 --- synthetic phenotype --- aortic regurgitation --- echocardiography --- magnetic resonance imaging --- vena contracta area --- longitudinal strain --- T1 mapping --- GDF8 --- myostatin --- AMI --- ceruloplasmin --- H-FABP --- heart-type fatty acid-binding protein --- FABP3 --- fatty acid-binding protein 3 --- HF --- cardiac biomarkers --- cardiac magnetic resonance imaging --- left ventricular systolic function --- magnetic resonance spectroscopy --- myocardial triglyceride content --- cell adhesion molecule --- repeated measurements --- pregnancy-associated plasma protein-A --- cohort studies --- cardiovascular diseases --- mitochondrial dysfunction --- circulating cells --- PBMCS --- platelets --- oxidative stress --- reactive oxygen species (ROS) --- mitochondrial DNA (mtDNA) --- herat failure --- liver-type fatty-acid-binding protein --- long-term outcomes --- cardiac intensive care units --- acute kidney injury --- myocardial infarction --- STEMI --- cardiovascular events --- cardiovascular death --- risk stratification --- sST2 --- Pentraxin-3 --- sudden cardiac death --- ventricular arrhythmia --- ventricular tachycardia --- chronic heart failure --- saliva --- salivary biomarkers --- CKD --- CVD --- PPCI --- left ventricular adverse remodelling --- circulating miRNAs --- NAFLD --- Framingham risk score --- risk prediction --- secondary prevention --- primary prevention --- NAFLD fibrosis score --- HFpEF --- HFrEF --- suPAR --- n/a