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This book reflects the tremendous growth peroxidases research has experienced in recent years, providing for the first time in over three decades a systematic, up-to-date treatment of the subject. From cancer in plants to unique saddle-shaped hemes in peroxidases, it consolidates vast amounts of information previously scattered in the professional literature, covering all aspects of these ubiquitous enzymes that act on a variety of substances and processes in living systems-their properties, reactions, crystal structures, cloning, and more.Complete with hundreds of vivid illustrations, many in color or 3D, Heme Peroxidases presents Welinder's recent classification of the enzymes according to their evolutionary development; X-ray crystallographic data on many peroxidases; a step-by-step introduction to modern spectroscopic techniques used in peroxidases research; an appendix listing amino acid sequences for all enzymes and catalases described in the book; and over 1,700 references to current results.This one-stop reference for analytical biochemists, biotechnologists, and others interested in the study and use of peroxidases, offers a critical review of the literature, and sorts through the various conflicting reports about peroxidase mechanisms. It familiarizes the reader with commercial and industrial applications in analytical biochemistry, biotechnology, medicine, agriculture, and the environment - addressing future trends in drug synthesis, water purification, and soil decontamination.

Peroxidase. --- Peroxydases

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Wegener’s granulomatosis (Wg), microscopic polyangiitis (PANM), Churg-strauss syndrome (SCS) and rapidly progressive glomerulonephritis (GNRP) are strongly associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA), separated into myeloperoxidase (MPO-ANCA) and protéinase 3 (PR3-ANCA). However, the importance of these auto antibodies remains unknown. Recent works have shown that ANCA anti-RP3 from patients with Wegener interfere with enzymatic activity of RP3.
To investigate the relationship between functional effects of MPO-ANCA and disease activity, we tested 6 patients with PANM , 4 patients with GNRP and one patient with control’s sera were obtained from patients ANCA-negative and without vasculitis.
In this work we have been search in the sera of patients, the enzymatic activity of MPO when disease is active (p<0.05). We haven’t found a significant diminution with patient presenting a GNRP or a Wg. Also, the inhibition of MPO is generally more frequent when the disease is active. The study of the mean of the enzymatic activity of the MPO in all patients is significantly different between active disease and remission disease. This mean is significantly lower when the disease is active (p<0.005).
These results suggest that the test of inhibition of MPO could become a test of marker of relapse of vasculitis associated at ANCA in patients treated at long-term La granulomatose de Wegener (Wg), la polyangéite microscopique (PANM), la glomédulonéphrite rapidement progressive (GNRP) et le syndrome de Churg et Strauss (SCS) sont fréquemment associés à la présence d’anticorps anti-cytoplasme de neutrophiles (ANCA), dirigés contre la protéinase 3 (PR3) ou la myéloperoxydase (MPO). Cependant, l’importance de ces auto-anticorps reste inconnue. Il a été rapporté que les ANCA anti-RP3 inhibent l’activité enzymatique de la MPO chez les patients atteints d’une Wg active.
Pour investiguer la relation entre les effets des ANCA anti-MPO sur l’activité enzymatique de la MPO et l’activité de la maladie, nous avons testé 6 patients atteints de PANM, 4 patients atteints de GNRP et un patient atteint de Wg. Les contrôles incluent six patients non atteints de vascularités et ANCA.
Dans ce travail, nous avons recherché dans les sérums des patients, l’activité enzymatique de la MPO par une méthode d’inhibition, les ANCA par la méthode ELISA et par IFI, et la CPR par une méthode d’immunodépression de particules.
Testés individuellement, 4 patients sur 6 atteints de PANM ont montré une diminution significative de l’activité enzymatique de la MPO en période de maladie active (p<0.05). Cette diminution significative n’est cependant présente chez aucun patient atteint de GNRP ou de Wg. Quant à l’inhibition de la MPO, elle est généralement plus fréquente en période active qu’en période de rémission de la maladie. L’étude de la moyenne des activités enzymatiques chez tous les patients a mis en évidence une différence significative en fonction de l’activité de la maladie. Cette moyenne est significativement plus basse en période de maladie active (p<0.005).
Ces résultats suggèrent que le test d’inhibition de la MPO pourrait devenir un test marqueur de rechute des vascularités à ANCA chez des patients suivis à long terme

Peroxidase --- Antibodies, Antineutrophil Cytoplasmic

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Histochemistry --- Neural circuitry --- Peroxidase --- Analysis

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Lactoperoxidase is an enzyme that is naturally present in milk. The activation of the lactoperoxidase in the presence of hydrogen peroxide and thiocyanate, both of which are naturally present in milk, has a bacteriostatic effect on raw milk and effectively extends the shelf life of raw milk for 7-8 hours under ambient temperatures of around 30°C or longer at lower temperatures. Such an extension of the shelf-life particularly under warm ambient conditions can allow adequate time for the milk to be transported from the collection point to a processing centre without refrigeration. FAO and WHO convened a technical meeting to review the most recent scientific information on the risks and benefits of the lactoperoxidase system, and its application to international trade. This report provides the output of the meeting including a summary report of the most recent information on the topic, and the discussions and recommendations of the technical meeting.

Dairy processing --- Food --- Milk --- Peroxidase --- Preservation --- Microbiology

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Peroxidase --- Botanical chemistry --- Plant physiology --- Peroxidase --- Botanical chemistry --- Plant physiology --- Bibliography --- Bibliography --- Bibliography