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Osteoporosis --- Bones --- Vitamin D deficiency --- Diseases --- Osteoporosi --- Estudi de casos --- Casos --- Formulació clínica --- Malalties dels ossos --- Hiperparatiroïdisme --- Osteòlisi --- Estudis de casos --- Osteoporosi. --- Estudi de casos.

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Fractures. --- Osteoporosis. --- Orthopedics. --- Orthopaedics --- Orthopedia --- Surgery --- Bones --- Vitamin D deficiency --- Callus --- Diseases --- Fractures --- Wounds and injuries --- Osteoporosi

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This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Aging. --- Developmental biology. --- Geriatrics. --- Endocrinology . --- Biogerontology. --- Geriatrics/Gerontology. --- Endocrinology. --- Internal medicine --- Hormones --- Medicine --- Gerontology --- Older people --- Development (Biology) --- Biology --- Growth --- Ontogeny --- Age --- Ageing --- Senescence --- Developmental biology --- Longevity --- Age factors in disease --- Diseases --- Health and hygiene --- Physiological effect --- Osteoporosis. --- Bones --- Vitamin D deficiency --- Osteoporosi --- Malalties musculars --- Miopaties --- Malalties de l'aparell locomotor --- Malalties de la llengua --- Malalties neuromusculars --- Miàlgia --- Malalties dels ossos --- Hiperparatiroïdisme --- Osteòlisi

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The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

Cardiology. --- Pathology. --- Biomedical engineering. --- Biomedical Engineering/Biotechnology. --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Heart --- Internal medicine --- Biomedical Engineering. --- Calcification, Physiologic. --- Vascular Calcification. --- Cardiovascular Diseases. --- Cardiovascular Disease --- Disease, Cardiovascular --- Diseases, Cardiovascular --- Cardiology --- Vascular Calcinosis --- Calcification, Vascular --- Calcifications, Vascular --- Calcinoses, Vascular --- Calcinosis, Vascular --- Vascular Calcifications --- Vascular Calcinoses --- Vascular Stiffness --- Calcification, Physiological --- Physiologic Calcification --- Bone Mineralization --- Mineralization, Bone --- Physiological Calcification --- Bone and Bones --- Engineering, Biomedical --- Clinical Engineering --- Engineering, Clinical --- Biomedical Technology --- Minerals in the body. --- Body composition --- Mineral metabolism --- Calcificació --- Biomineralització --- Malalties del cor --- Malalties dels ossos --- Cardiologia --- Medicina interna --- Anestèsia en cardiologia --- Cardiologia geriàtrica --- Cardiologia pediàtrica --- Cardiologia veterinària --- Medicina intensiva en cardiologia --- Malalties cardiovasculars --- Malalties vasculars --- Malalties òssies --- Osteopaties --- Malalties de l'aparell locomotor --- Displàsia fibrosa òssia --- Osteïtis --- Osteodistròfia renal --- Osteoporosi --- Pseudoartrosi --- Raquitisme --- Ortopèdia --- Atac de cor --- Cardiopaties --- Malalties cardíaques --- Arrítmia --- Aturada cardíaca --- Dilatació del cor --- Endocarditis --- Insuficiència cardíaca --- Malalties del pericardi --- Malformacions del cor --- Malalts cardíacs --- Mineralització biològica --- Minerals en l'organisme --- Càlculs --- Trastorns del metabolisme --- Calci en l'organisme --- Teixit ossi