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Nous avons souhaité une nouvelle édition sans refonte complète de cet ouvrage, car le succès de la première édition montre que le principe de ce livre est bien adapté à une prise en charge multidisciplinaire de cette pathologie complexe. L'actualisation des progrès techniques réalisés tant sur le plan diagnostique que thérapeutique était pourtant nécessaire. Deux sujets méritent une attention particulière : la place de l'IRM dans la stratégie diagnostique et thérapeutique et la place de la chirurgie vertébrale dans la stratégie globale de la prise en charge de patients atteints de métastase ve

Spinal Neoplasms --- Bone metastasis --- Spine --- Métastases osseuses --- Colonne vertébrale --- secondary. --- Cancer --- Bone metastasis. --- Cancer. --- Métastases osseuses --- Colonne vertébrale --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Bones --- Metastasis

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Bone Cancer, 2nd Edition comprehensively investigates key discoveries in the field of bone biology over the last five years that have led to the development of entirely new areas for investigation, such as therapies which combine surgery and biological approaches. The Second Edition expands on the original overview of bone cancer development (physiology and pathophysiology), with key chapters from the first edition, and offers numerous new chapters describing the new concepts of bone cancer biology and therapy, for both primary bone tumors as well as bone metastases. Each chapter has been written by internationally recognized specialists on the bone cancer microenvironment, bone metastases, osteoclast biology in bone cancer, proteomics, bone niche, circulating tumor cells, and clinical trials. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for everyone within the medical and cancer research communities. Bone Cancer continues to offer the only translational reference to cover all aspects of primary bone cancer and bone metastases - from bench to bedside: development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Presents a comprehensive, translational source for all aspects of primary bone cancer and bone metastases in one reference work Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Offers insights to research clinicians (oncologists and radiologists) into understanding the molecular basis of bone cancer, leading to more well-informed diagnoses and treatment of tumors and metastases Offers insights to bone biologists into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays.

Bones --- Bone metastasis. --- Cancer. --- Bone Neoplasms. --- Cancer --- Treatment. --- Bone Neoplasms --- Cancer of the Bone --- Neoplasms, Bone --- Bone Cancer --- Cancer of Bone --- Bone Neoplasm --- Neoplasm, Bone --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Metastasis

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"Bone Metastases: A Translational and Clinical Approach" serves as both an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume: describes the molecular and cellular mechanisms involved in the formation of bone metastases, comments on the role of angiogenesis, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. This volume also covers the use of radiotherapy, surgery and systemic treatments for the management of metastatic bone disease and new therapeutic approaches. Moreover it may also serve as a guide for the clinical and therapeutic management of patients with metastatic bone disease. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for medical researchers, oncologists, orthopaedic surgeons and clinicians.

Bone metastasis. --- Bones -- Cancer. --- Bone metastasis --- Neoplastic Processes --- Bone Diseases --- Neoplasms by Site --- Neoplasms --- Pathologic Processes --- Musculoskeletal Diseases --- Diseases --- Pathological Conditions, Signs and Symptoms --- Bone Neoplasms --- Neoplasm Metastasis --- Medicine --- Health & Biological Sciences --- Oncology --- Bones --- Cancer. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Cancer research. --- Oncology. --- Biomedicine. --- Cancer Research. --- Metastasis --- Cancer --- Oncology  . --- Tumors --- Cancer research

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Bone and Cancer is the fifth volume in the series Topics in Bone Biology, edited by Felix Bronner and Mary C. Farach-Carson. This title features current knowledge on mechanisms of metastasis, the role of the bone microenvironment in cancer progression, how inflammatory cytokines function in metastasis and osteolysis, and the role of osteoblasts, thus bringing to the clinician and researcher cellular and molecular findings that affect the search for drugs and lead to translational studies. Each chapter contains an extensive bibliography that permits readers to learn more about specific aspects of the chapter topic. Tables, diagrams and figures illustrate and clarify cellular events that lead to development and progression of cancer in bone. Insights based on cellular and molecular events clarify the clinical picture and may lead to translational research and focused therapy. The chapters, authored by authorities from throughout the world, emphasize how current knowledge can lead to better treatement. Other titles in this series:- Bone Formation Bone Resorption Engineering of Functional Skeletal Tissues Bone and Osteoarthritis.

Bone metastasis. --- Bone. --- Cancer. --- Bones --- Bone Marrow --- Bone Marrow Neoplasms --- Bone Neoplasms --- Neoplasms by Site --- Bone Diseases --- Hematologic Neoplasms --- Bone Marrow Diseases --- Immune System --- Musculoskeletal Diseases --- Hematologic Diseases --- Hemic and Immune Systems --- Neoplasms --- Hemic and Lymphatic Diseases --- Anatomy --- Diseases --- Oncology --- Medicine --- Health & Biological Sciences --- Cancer --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Cancer research. --- Oncology. --- Orthopedics. --- Medicine & Public Health. --- Cancer Research. --- Metastasis --- Oncology  . --- Tumors --- Orthopaedics --- Orthopedia --- Surgery --- Cancer research

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This book presents up-to-date information on one of the hottest topics in prostate cancer, namely bone metastases. The most recent developments with respect to biology, pathology, diagnosis, and treatment are described, providing readers with an excellent understanding of the mechanisms of metastasis formation, the characteristics of metastases, their aggressiveness, and prognostic factors for treatment response. The coverage includes discussion of all of the best available options (laboratory, radiology, and nuclear medicine) for achieving early diagnosis and both established and novel therapeutic approaches. Detailed information is provided on hormonal manipulations, bone-targeted agents, vaccines, taxanes, and other treatments that are enriching the therapeutic armamentarium. The editors can be considered leaders in the field, with great experience in diagnostic and clinical oncology and research, and the authors are experts in diverse specialties. This ensures a multidisciplinary approach, mirroring the current situation in which treatment in patients with bone metastases is undertaken by a team of specialists and health professionals in a variety of fields.

Bone metastasis. --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Medicine. --- Nuclear medicine. --- Radiotherapy. --- Oncology. --- Orthopedics. --- Pathology. --- Urology. --- Medicine & Public Health. --- Nuclear Medicine. --- Bones --- Cancer --- Treatment. --- Metastasis --- Oncology  . --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Orthopaedics --- Orthopedia --- Surgery --- Radiation therapy --- Electrotherapeutics --- Hospitals --- Medical electronics --- Medical radiology --- Therapeutics, Physiological --- Phototherapy --- Atomic medicine --- Radioisotopes in medicine --- Radioactive tracers --- Radioactivity --- Genitourinary organs --- Tumors --- Radiological services --- Physiological effect