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Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse application of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry.
Pyridine --- Derivatives. --- Chemistry, Organic. --- Pyridines --- Organic Chemistry Phenomena --- Chemistry, Organic --- chemical synthesis --- methods
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Heteropolyacids as Highly Efficient and Green Catalysts Applied in Organic Transformations introduces heteropolyacids (HPAs) as promising candidates for use as green catalysts. This book initially presents an overview of chemistry of HPAs, including the history of their discovery and applications, systematic classifications, solubility, coordination and binding chemistry, isomerization, stability, redox activity, acidic properties, basicity, skeleton structure, structure types, self-assemblage, surface area, electrochemical behavior, methods of investigation, and characterization. Other sections present and compare the applications of HPAs as homogeneous and heterogeneous catalysts.
Green chemistry. --- Acids. --- Catalysts. --- Chemistry, Organic. --- Acids --- Catalysis --- Organic Chemistry Phenomena --- Green Chemistry Technology
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Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Natural products. --- Products, Natural --- Raw materials --- Phytochemicals. --- Bioorganic chemistry. --- Bioactive compounds. --- Biological products --- Phytochemicals --- Organic Chemistry Phenomena --- Chemistry Techniques, Analytical --- chemistry
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Biochemistry. --- Chemistry. --- Chemistry, Organic. --- Organic reaction mechanisms. --- Chemistry, Pharmaceutical. --- Organic Chemistry Phenomena --- Biochimie --- Chimie organique --- Réactions chimiques organiques --- Chimie pharmaceutique --- Biochemistry. --- Chemistry. --- Organic reaction mechanisms. --- Mécanismes
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Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products.
Natural products. --- Products, Natural --- Raw materials --- Chemistry, Organic. --- Chemistry, Organic --- Research. --- Organic chemistry --- Chemistry --- Phytochemicals. --- Bioorganic chemistry. --- Bioactive compounds. --- Biological Products --- Phytochemicals --- Organic Chemistry Phenomena --- Chemistry Techniques, Analytical --- chemistry
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Addition, Elimination and Substitution: Markovnikov, Hofmann, Zaitsev and Walden: Discovery and Development discusses foundational reactions in organic chemistry and their major protagonists, contributions to synthesis, and history. Hofmann, Zaitsev, and Markovnikov are introduced, along with their major discoveries and contributions to organic chemistry. The history of controversies around Markovnikovs Rule are addressed. The book introduces Waldens original demonstration of configuration inversion, then discusses bimolecular elimination reactions, regioselective addition reactions, regiospecific alkene synthesis, and the development of modern reactions with configuration inversion.
Chemistry, Organic. --- Chemical reactions. --- Organic compounds --- Synthesis. --- Chemistry, Organic --- Chemistry, Synthetic organic --- Organic synthesis (Chemistry) --- Synthetic organic chemistry --- Reactions, Chemical --- Chemical processes --- Organic chemistry --- Chemistry --- Synthesis --- Organic Chemistry Phenomena --- History. --- history
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Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers the chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates, and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources, and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents and many more. Some of these scaffolds like purines are also known to have involvement in biological processes and are part of the framework of genetic material. This book focuses on the classification, structural chemistry, and chemical and physical properties along with various approaches for their synthesis.
Drug development. --- Pyrimidines. --- Heterocyclic compounds --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Development --- Heterocyclic chemistry. --- Heterocyclic compounds. --- Pyrimidines --- Heterocyclic Compounds, Fused-Ring --- Drug Discovery --- Organic Chemistry Phenomena --- Chemistry, Pharmaceutical --- Structure-Activity Relationship --- Research. --- chemistry --- chemical synthesis --- methods
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Benzodiazepine-Based Drug Discovery covers benzodiazepines and benzothiazepines, which constitute two pivotal classes of heterocyclic compounds widely used as core structures of medicinal drugs for the treatment of depression, epilepsy, seizures and muscle spasms. 1,4-Benzodiazepine, 1,5-benzodiazepine, and 1,5-benzothiazepine are the most studied groups of benzodiazepines and benzothiazepines because of their outstanding potential biological activities. This book offers a broad range of recent developments and detailed coverage of the synthesis and biological activities of the drugs based on benzodiazepine and benzothiazepine matrixes, and is an ideal reference guide to researchers working in organic and medicinal chemistry.
Benzodiazepines. --- Drug development. --- Development of drugs --- Drugs --- New drug development --- Pharmacology --- Pharmacy --- Benzene --- Bicyclic diazepines --- Tranquilizing drugs --- Development --- Heterocyclic chemistry. --- Heterocyclic compounds. --- Benzodiazepines --- Heterocyclic Compounds --- Drug Discovery --- Organic Chemistry Phenomena --- Chemistry, Pharmaceutical --- Research. --- chemistry --- chemical synthesis --- methods
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Organic chemistry --- Chemistry, Organic --- Organic Chemistry Phenomena --- organische chemie --- Organic Chemistry Phenomenon --- Organic Chemistry Process --- Organic Chemistry Concepts --- Organic Chemistry Processes --- Chemistry Process, Organic --- Chemistry Processes, Organic --- Concept, Organic Chemistry --- Concepts, Organic Chemistry --- Organic Chemistry Concept --- Phenomena, Organic Chemistry --- Phenomenon, Organic Chemistry --- Process, Organic Chemistry --- Processes, Organic Chemistry --- Organic Chemistry --- Chemistry
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