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"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE  is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer.".

Biology. --- Cancer. --- Medical Oncology -- periodicals. --- Neoplasms -- periodicals. --- Cancer cells --- Nuclear membranes --- Diseases --- Biological Science Disciplines --- Cell Membrane Structures --- Proteins --- Nuclear Matrix-Associated Proteins --- Metabolic Phenomena --- Cell Physiological Phenomena --- Amino Acids, Peptides, and Proteins --- Nuclear Proteins --- Cell Membrane --- Phenomena and Processes --- Natural Science Disciplines --- Disciplines and Occupations --- Chemicals and Drugs --- Cellular Structures --- Cells --- Anatomy --- Physiology --- Lamins --- Organelle Shape --- Metabolism --- Neoplasms --- Membrane Proteins --- Nuclear Envelope --- Medicine --- Health & Biological Sciences --- Oncology --- Cancer cells. --- Nuclear membranes. --- Nuclear envelope --- Medicine. --- Cancer research. --- Medical microbiology. --- Proteins. --- Cell membranes. --- Biomedicine. --- Cancer Research. --- Medical Microbiology. --- Protein Science. --- Membrane Biology. --- Biomedicine general. --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Cell membranes --- Cell nuclei --- Pathology, Cellular --- Oncology. --- Microbiology. --- Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Microbial biology --- Microorganisms --- Tumors --- Composition --- Proteins . --- Cell membranes . --- Biomedicine, general. --- Health Workforce