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Chiral drugs --- Optical isomers --- Biotechnology --- OPTICAL ROTATION --- ISOMERISM AND ISOMERS, OPTICAL --- ORGANIC COMPOUNDS --- BIOTECHNOLOGY --- PREPARATION
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Stereochemistry. --- Diastereoisomers. --- Diastereomers --- Optical isomers --- Atoms --- Molecular asymmetry --- Chemical structure --- Chemistry --- Isomerism --- Polarization (Light) --- Space arrangement
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Optical isomers --- Chirality. --- Stereochemistry --- Symmetry (Physics) --- Enantiomers --- Isomers, Optical --- Isomers, Optically active --- Optically active isomers --- Stereoisomers --- Analysis.
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Supramolecular chemistry. --- Chirality. --- Enantiomers. --- Chemistry, Physical and theoretical --- Macromolecules --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Chirality --- Stereochemistry --- Symmetry (Physics) --- Enantiomers
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Chirality --- Enantiomers --- Enantoimers --- Chiralité --- Biotechnology --- Separation --- Chirality. --- Separation. --- Biotechnology. --- 544.122.3 --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Stereochemistry --- Symmetry (Physics) --- Amino acids --- industry --- Séparation --- Separating --- Production --- Chemical synthesis --- epoxy compounds --- Aminotransferases --- Aspartame --- Phospholipids --- Biocatalysts --- Chiralité --- Separating. --- Enantiomers - Separation. --- Enantiomers - Biotechnology. --- Enantiomers - Separation --- Enantiomers - Biotechnology --- Materiau optiquement pur --- Chiralite --- Captopril --- Beta-lactame --- Mentho --- Enantiomere
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Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of resul
Asymmetric synthesis. --- Enantiomers. --- Enantioselective catalysis. --- Asymmetric synthesis --- Enantiomers --- Chemistry --- Physical Sciences & Mathematics --- Organic Chemistry --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Chirality --- Chiral catalysis --- Enantioselective heterogeneous catalysis --- Heterogeneous asymmetric catalysis --- Heterogeneous catalysis --- Asymmetric induction --- Induction, Asymmetric --- Synthesis, Asymmetric --- Asymmetry (Chemistry) --- Organic compounds --- Synthesis
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Chemical tests and reagents. --- Nuclear magnetic resonance spectroscopy. --- Chirality. --- Chimie --- Spectroscopie de la résonance magnétique nucléaire --- Chiralité --- Essais et réactifs --- Enantiomers --- 544.176 --- 544.122.3 --- Derivatization. --- Chemical reactions --- Stereochemistry --- Symmetry (Physics) --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Chirality --- NMR spectroscopy --- Spectroscopy, NMR --- Spectroscopy, Nuclear magnetic resonance --- Nuclear spectroscopy --- Knight shift --- Chemical reagents --- Reagents, Chemical --- Indicators and test-papers --- Derivatives. --- Nuclear magnetic resonance spectra. Nuclear Overhauser effect spectra --- Spectroscopie de la résonance magnétique nucléaire --- Chiralité --- Essais et réactifs --- Chemical tests and reagents --- Derivatization --- Nuclear magnetic resonance spectroscopy --- Derivatives
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The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the first time, a team of experienced analysts from industry and academe presents a comprehensive review of the various mechanisms that result in enantiomer separations. A better understanding of these processes is crucial for setting as well as improving chiral separation procedures and also for developing new applications. The coverage in this book includes a range of separation methods, such as gas, liquid, or countercurrent chromatography, and capillary electrophoresis. The special case of chiral ionic liquids is examined in detail. Most modern chiral selectors are discussed, including derivatized polysaccharide- and cyclodextrin-based selectors, along with a newly introduced class of carbohydrates: the cyclofructose selectors. This publication will be required reading not only for research and development departments in the pharmaceutical and cosmetic industries, but also for researchers in toxicology, environmental monitoring, and food research.
Chirality. --- Enantiomers -- Separation. --- Liquid chromatography. --- Molecular recognition --- Enantiomers --- Human Anatomy & Physiology --- Chemistry --- Health & Biological Sciences --- Physical Sciences & Mathematics --- Animal Biochemistry --- Analytical Chemistry --- Biotechnology --- Enantiomers. --- Chromatographic analysis. --- Analysis, Chromatographic --- Chromatography --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Chemistry. --- Pharmacy. --- Pharmacology. --- Chromatography. --- Food --- Pharmacology/Toxicology. --- Food Science. --- Environmental Monitoring/Analysis. --- Biotechnology. --- Chemistry, Analytic --- Phase partition --- Optical isomers --- Chirality --- Stereochemistry --- Symmetry (Physics) --- Toxicology. --- Food science. --- Monitoring/Environmental Analysis. --- Science --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Drugs --- Materia medica --- Toxicology --- Analytical chemistry --- Food—Biotechnology. --- Environmental monitoring. --- Biomonitoring (Ecology) --- Ecological monitoring --- Environmental quality --- Monitoring, Environmental --- Applied ecology --- Environmental engineering --- Pollution --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Pharmacy --- Measurement --- Monitoring --- Physiological effect
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This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.
Chemistry. --- Pharmaceutical technology. --- Organic chemistry. --- Medicinal chemistry. --- Medicinal Chemistry. --- Organic Chemistry. --- Pharmaceutical Sciences/Technology. --- Analytical biochemistry. --- Natural products --- Enantiomers. --- Spectra. --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Chirality --- Analytic biochemistry --- Biochemistry --- Chemistry, Analytic --- Biochemistry. --- Chemistry, Organic. --- Pharmaceutical laboratory techniques --- Pharmaceutical laboratory technology --- Technology, Pharmaceutical --- Technology --- Organic chemistry --- Chemistry --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Medical sciences --- Composition --- Bioanalytic chemistry --- Bioanalytical chemistry --- Analytical chemistry --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Drugs --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry
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Now in its updated second edition, this book describes emerging chiral environmental pollutants and their importance in environmental and human toxicology, as well as enantiomer selective separation and analytical methods. Compared to the first edition from 2001, the book has been completely restructured and a wealth of new material has been added to account for new developments. The book reports on the modern enantiomer selective separation methods, including enantio-selective chromatography techniques, which have even been successfully tested in space during the ESA Rossetta mission. The authors clearly outline why the topic of chiral environmental pollutants has become even more important: many new chiral compounds have been released in recent years (e.g. as new pharmaceuticals or agrochemicals), and traces of these compounds can now be found in the environment. The authors explain that (and how) chirality can be a very important feature for the bioactivity of anthropogenic pollutants. In this book, readers find an introduction to the topic, including all important aspects, from the introduction of new enantiomer selective analytical methods, and of emerging chiral environmental pollutants, to aspects on environmental and human toxicology and exposure, risk assessment, and aspects on climate change as well as other new aspects on chirality in the environment. The book is thus a must-read for everybody working in the field of chiral environmental pollutants, but it is also beneficial for teaching purposes in specialized post-graduate courses in advanced analytical chemistry, pharmaceutical analytics, or environmental chemistry.
Environmental chemistry. --- Chromatography. --- Pollution. --- Ecotoxicology. --- Food—Biotechnology. --- Pharmacology. --- Environmental Chemistry. --- Pollution, general. --- Food Science. --- Pharmacology/Toxicology. --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Ecotoxicology --- Pollutants --- Pollution --- Environmental health --- Toxicology --- Chemical pollution --- Contamination of environment --- Environmental pollution --- Contamination (Technology) --- Asbestos abatement --- Bioremediation --- Environmental engineering --- Environmental quality --- Factory and trade waste --- Hazardous waste site remediation --- Hazardous wastes --- In situ remediation --- Lead abatement --- Refuse and refuse disposal --- Analysis, Chromatographic --- Chromatography --- Analytical chemistry --- Phase partition --- Chemistry, Environmental --- Chemistry --- Ecology --- Physiological effect --- Environmental aspects --- Environmental toxicology. --- Enantiomers --- Toxicology. --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Optical isomers --- Chirality
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