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The botulinum toxin has been widely applied in the treatment of functional urological diseases, such as overactive bladder, neurogenic detrusor overactivity, interstitial cystitis, and chronic pelvic pain syndrome. Evidence has shown that the botulinum toxin not only affects the release of neuropeptides from motor nerve endings, but also connects sensory nerves to the central nervous system. Inflammation in the central nervous system can be reduced after botulinum toxin treatment. The scope of therapeutic targets involves detrusor overactivity, sensory disorders, bladder pain and pelvic pain, and inflammatory disorders of the bladder, prostate, and bladder outlet. Although the actual pathophysiological mechanism of the action of the botulinum toxin has not been completely demonstrated, an anti-inflammation effect might be the predominant therapeutic mechanism for functional urological disorders such as an overactive bladder, bladder hypersensitivity, interstitial cystitis, chronic pelvic pain syndrome, chronic prostatitis, and lower urinary tract symptoms/benign prostatic hyperplasia. This Special Issue of Toxins covers the therapeutic potentials of the botulinum toxin on lower urinary tract dysfunctions, with emphasis on the mechanism of pharmacological action and clinical effects.

urethra --- onabotulinumtoxinA --- voiding --- therapeutic outcome --- lower urinary tract symptoms --- botulinum toxin --- benign prostatic hyperplasia --- prostatitis --- inflammation --- Botulinum toxin --- chronic prostatitis --- interstitial cystitis --- treatment --- bladder pain --- botulinum toxin A --- predictor --- maximal bladder capacity --- hydrodistention --- urethral sphincter --- urethral sphincter dysfunction --- urodynamics --- drug delivery --- overactive bladder --- painful bladder syndrome --- molecular mechanism --- chronic pelvic pain syndrome --- pelvic pain --- functional urology disorder --- human --- network meta-analysis --- OnabotulinumtoxinA --- peripheral tibial nerve stimulation --- sacral neuromodulation --- bladder --- sensation --- therapy --- pathophysiology --- diabetes mellitus --- mid-urethral sling --- antimuscarinics --- urinary incontinence --- functional urological disorders --- pain --- neurogenic detrusor overactivity

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"Botulinum Toxin in Facial Rejuvenation, 2nd Edition, covers the entire range of the use of botulinum toxin for cosmetic purposes. Dr. Kate Coleman offers practical guidance for safe handling, selection and assessment of patients, potential complications and pitfalls, and aesthetic techniques, as well as comparative modalities and long-term management. This is an ideal resource for anyone who offers this sought-after procedure, including cosmetic surgeons, oculoplastic surgeons, dermatologists, physician's assistants, and registered nurses"--Publisher's description.

Botulinum toxin --- Facelift. --- Botulinum Toxins, Type A --- Face --- Therapeutic use. --- Faces --- Botox --- Botulinum A Toxin --- Botulinum Neurotoxin A --- Clostridium Botulinum Toxin Type A --- Clostridium botulinum A Toxin --- Meditoxin --- Neuronox --- Oculinum --- Onabotulinumtoxin A --- OnabotulinumtoxinA --- Vistabel --- Vistabex --- Botulinum Toxin Type A --- Neurotoxin A, Botulinum --- Toxin, Botulinum A --- Face lift --- Facelifts --- Rhytidectomy --- Rhytidoplasty --- Surgery, Plastic --- Surgery --- Cosmetic Techniques. --- Injections, Intramuscular. --- Intramuscular Injections --- Injection, Intramuscular --- Intramuscular Injection --- Intramuscular Absorption --- Cosmetic Technics --- Cosmetic Technic --- Cosmetic Technique --- Technic, Cosmetic --- Technics, Cosmetic --- Technique, Cosmetic --- Techniques, Cosmetic --- Dermal Fillers --- Dermatologic Surgical Procedures --- Botulinum Neurotoxin Type A --- Botulinum Toxin A --- Toxin A, Botulinum