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The discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology. A general interest in leptin has rapidly produced inroads into unexpected areas of physiology that may eventually elucidate the varied relationships of adiposity to human health and disease. These developments have been paralleled by a rigorous investigation as a product of pharmaceutical interest. The broad range of physiology and the clinical situations in which leptin is now implicated is reviewed for the first time in the present volume. ***Series Editor's comments**** This volume integrates cutting edge basic and clinical information encompassing the expression of leptin and leptin receptors, pathophysiology and clinical role of leptin- a new neuroendocrine hormone with pleiotropic roles in appetite regulation, metabolic, inflammatory, neoplastic, cardiovascular and reproductive functions. This single volume encyclopedic coverage is indispensable to students, postdoctoral trainees, fellows, scientists and practitioners interested in neuroendocrine peptide control of multiple cellular functions. Shlomo Melmed, M.D. Series Editor Endocrine Updates .

Leptin. --- Leptin --- Physiological effect. --- Ob protein --- Medicine. --- Endocrinology. --- Medicine & Public Health. --- Hormones

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Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.

Neuroendocrinology. --- Paraneurons. --- Stress (Physiology) --- Obesity --- Dopamine. --- Ghrelin. --- Leptin. --- Neuroscience --- Human Anatomy & Physiology --- Health & Biological Sciences --- Endocrine aspects. --- Hormonal aspects of physiological stress --- Endocrinology --- Neuroendocrine cells --- Neurons --- Chromaffin cells --- Neurology --- Neurohormones --- Adiposity --- Corpulence --- Fatness --- Overweight --- Body weight --- Metabolism --- Nutrition disorders --- Ob protein --- Hormones --- Motilin-related peptide --- Gastrointestinal hormones --- Peptide hormones --- Biogenic amines --- Bromocriptine --- Catecholamines --- Neurotransmitters --- Hormonal aspects --- Disorders --- stress --- Dopamine --- Ghrelin --- Leptin --- Seasonal regulation --- feeding --- HPA axis --- Hypothalamus --- circadian rhythms