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This book provides a comprehensive overview of chromatin research, detailing the structure, function, and history of chromatin, with a focus on nucleosome biology. It traces the advancements in chromatin research from its early beginnings to the present day, marking significant milestones such as the development of the nucleosome model and the rise of cryoelectron microscopy. The work discusses chromatin compaction, nucleosome positioning, histone variants, and chromatin remodeling, emphasizing the dynamic nature of chromatin and its role in gene regulation. The author aims to bridge historical insights with current research trends, offering a nuanced understanding of chromatin's role in cellular processes. This book is intended for researchers and practitioners in the fields of molecular genetics and epigenetics.

Chromatin. --- Nucleosomes. --- Chromatin --- Nucleosomes

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NUCLEOSOMES --- CHROMATIN --- BIOLOGICAL STUDIES

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Chromatin --- Chromatine --- CHROMATIN --- NUCLEOSOMES --- PROTEIN STRUCTURE --- BIOLOGICAL STUDIES

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins.Continues the legacy of this premier serial by containing quality chapters authored by leade

Chromatine. --- Chromosomal proteins. --- Nucleosomes -- chemistry. --- Chromosome Structures --- Nuclear Proteins --- Proteins --- Amino Acids, Peptides, and Proteins --- Genetic Structures --- Chromosomes --- Intranuclear Space --- Genetic Phenomena --- Chemicals and Drugs --- Cell Nucleus Structures --- Phenomena and Processes --- Cell Nucleus --- Intracellular Space --- Cellular Structures --- Cells --- Anatomy --- Histones --- Chromatin --- Nucleoproteins --- Biology --- Health & Biological Sciences --- Biophysics --- Histones. --- Chromatin. --- Nucleoproteins. --- Basic proteins. --- Ribonucleoproteins --- Nucleosomes. --- Basic proteins --- Dinucleosomes --- Mononucleosomes --- Polynucleosomes

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A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena.Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons.Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.

Cellular signal transduction. --- Cellular control mechanisms. --- Cell regulation --- Biological control systems --- Cell metabolism --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Alexander Gann. --- Bohr effect. --- Bruce Mayer. --- Cell Signaling. --- Genes and Signals. --- MWC enzymes. --- Mark Ptashne. --- Michaelis-Menten Enzymes. --- Tony Pawson. --- Wendell Lim. --- allosterome. --- bacterial aerotaxis. --- cyclic nucleotide gated channels. --- enzyme phenomenology. --- gene expression. --- genome packing. --- glycolosis. --- ligand-receptor binding. --- logic gates. --- membrane receptors. --- nucleosomes. --- phoshofructokinase. --- signal transduction.