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RNA --- RIBOSOMES --- NUCLEIC ACID CONFORMATION --- RNA --- RIBOSOMES --- NUCLEIC ACID CONFORMATION

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RNA, Ribosomal --- Colicins --- Escherichia coli --- Nucleic Acid Conformation --- genetics

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Biological techniques --- Enzymology --- Molecular biology --- Ribonucleic acid --- Metabolism --- ARN --- Messenger rna --- Ribonucleoproteins --- Rna precursors --- Rna splicing --- Rna, ribosomal --- Rna, transfer --- Amino acid sequence --- Nucleic acid conformation --- Rna

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Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also been discovered. Quadruplex Nucleic Acids discusses all aspects of the fundamentals of quadruplex structures, including their structure in solution and the crystalline state, the kinetics of quadruplex folding, and the role of cations in structure and

Molecular pharmacology --- Molecular biology --- Pharmacologie moléculaire --- Biologie moléculaire --- Quadruplex nucleic acids --- Nucleic Acid Conformation --- DNA --- Genetic Structures --- Nucleic Acids --- Molecular Conformation --- Genetic Phenomena --- Nucleic Acids, Nucleotides, and Nucleosides --- Molecular Structure --- Chemicals and Drugs --- Biochemical Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Pharmacologie moléculaire --- Biologie moléculaire

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Computational structural biology has made tremendous progress over the last two decades, and this book provides a recent and broad overview of such computational methods in structural biology. It covers the impact of computational structural biology on protein structure prediction methods, macromolecular function and protein design, and key methods in drug discovery. It also addresses the computational challenges of experimental approaches in structural biology. In addition to reviewing the current state of computational structural biology, each chapter ends with a brief, visionary discussion

Computational biology. --- Protein folding --- Proteins --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Folding of proteins --- Biology --- Bioinformatics --- Computer simulation. --- Mathematical models. --- Structure --- Folding --- Conformation --- Computational biology --- Drug design. --- Nucleic acid conformation. --- Protein conformation. --- Protein folding. --- Rna. --- Methods. --- Computer simulation --- Mathematical models --- Proteins - Structure - Computer simulation --- Protein folding - Computer simulation --- Proteins - Structure - Mathematical models --- Protein folding - Mathematical models