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Undoubtedly, pain conditions the quality of life of millions of people worldwide suffering a wide range of diseases. Major research efforts are being made by the international scientific community to determine the mechanisms underlying nociception. Growing evidence points out a complex network including oxidative and nitrosative stress, inflammatory response and cation signaling. In this sense, transient receptor potential (TRP) channels have attracted researchers’ attention. Expression levels are very different in tissues and cells mediating a myriad of processes in our organism. At the neurological level, it has been observed that the expression levels of four TRP channels (TRPA1, TRPM2, TRPV1, and TRPV4) are high in neurons related to nociception, including dorsal root ganglion and trigeminal ganglia neurons. For this reason, this research field promises to shed light on this intricated matrix linking oxidative stress, calcium signaling (via TRP channels), and inflammatory signals in different pain modalities, including neuropathic pain and chemotherapy-induced peripheral pain. In such a way, all this intense research activity will enable us to design individual and rational treatment strategies for pain relief, such as the use of molecular neurosurgery.

cation signaling --- pain --- nervous system --- nociception --- TRP channels --- oxidative stress

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Pain --- Medische psychologie --- Treatment. --- Gezondheidspsychologie. --- Analgesia, Conduction --- Pain Management. --- Pain Measurement. --- Analog Pain Scale --- Assessment, Pain --- McGill Pain Scale --- Visual Analog Pain Scale --- Analgesia Tests --- Analogue Pain Scale --- Formalin Test --- McGill Pain Questionnaire --- Nociception Tests --- Pain Assessment --- Tourniquet Pain Test --- Visual Analogue Pain Scale --- Analgesia Test --- Analog Pain Scales --- Analogue Pain Scales --- Assessments, Pain --- Formalin Tests --- Measurement, Pain --- Measurements, Pain --- Nociception Test --- Pain Assessments --- Pain Measurements --- Pain Questionnaire, McGill --- Pain Scale, Analog --- Pain Scale, Analogue --- Pain Scale, McGill --- Pain Scales, Analog --- Pain Scales, Analogue --- Pain Test, Tourniquet --- Pain Tests, Tourniquet --- Questionnaire, McGill Pain --- Scale, Analog Pain --- Scale, Analogue Pain --- Scale, McGill Pain --- Scales, Analog Pain --- Scales, Analogue Pain --- Test, Analgesia --- Test, Formalin --- Test, Nociception --- Test, Tourniquet Pain --- Tests, Analgesia --- Tests, Formalin --- Tests, Nociception --- Tests, Tourniquet Pain --- Tourniquet Pain Tests --- Management, Pain --- Managements, Pain --- Pain Managements --- Chronic Disease --- therapy --- Drug Therapy --- Analgesia --- Treatment --- Pain Management --- Pain Measurement --- Pain - therapy --- Pain - Treatment

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Medische psychologie --- Gezondheidspsychologie. --- Pain Management. --- Pain Measurement. --- Analog Pain Scale --- Assessment, Pain --- McGill Pain Scale --- Visual Analog Pain Scale --- Analgesia Tests --- Analogue Pain Scale --- Formalin Test --- McGill Pain Questionnaire --- Nociception Tests --- Pain Assessment --- Tourniquet Pain Test --- Visual Analogue Pain Scale --- Analgesia Test --- Analog Pain Scales --- Analogue Pain Scales --- Assessments, Pain --- Formalin Tests --- Measurement, Pain --- Measurements, Pain --- Nociception Test --- Pain Assessments --- Pain Measurements --- Pain Questionnaire, McGill --- Pain Scale, Analog --- Pain Scale, Analogue --- Pain Scale, McGill --- Pain Scales, Analog --- Pain Scales, Analogue --- Pain Test, Tourniquet --- Pain Tests, Tourniquet --- Questionnaire, McGill Pain --- Scale, Analog Pain --- Scale, Analogue Pain --- Scale, McGill Pain --- Scales, Analog Pain --- Scales, Analogue Pain --- Test, Analgesia --- Test, Formalin --- Test, Nociception --- Test, Tourniquet Pain --- Tests, Analgesia --- Tests, Formalin --- Tests, Nociception --- Tests, Tourniquet Pain --- Tourniquet Pain Tests --- Management, Pain --- Managements, Pain --- Pain Managements --- Pain --- Chronic Disease --- therapy --- Drug Therapy --- Analgesia --- Pain Management --- Pain Measurement --- Pain - therapy

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Iedereen krijgt in het leven te maken met pijn. Soms wordt acuut chronisch, en gaat de pijn niet meer weg. Wereldwijd kampt 1 op de 5 mensen met chronische pijn. In België is dat bijna 1 op de 4. Het is een dagelijkse strijd, maar met een gemeenschappelijk front. Niemand staat alleen.Topdokter Bart Morlion heeft zijn levenswerk gemaakt van de bestrijding van chronische pijn. De professor is een wereldexpert die expertise koppelt aan empathie, kritische zin aan een constructieve visie. Hij verbloemt nooit en spreekt niet in raadsels.Zo ook niet in dit boek. Hij haalt kennis uit oost en west, combineert studies met eigen ervaring, gaat voorbij prikken en pillen, neemt het gezondheidsbeleid op de korrel, pleit voor meer aandacht voor pijnbestrijding.Het is bovenal een hoopgevend verhaal. Van leren omgaan met pijn. Van verantwoordelijkheid nemen. Van bewuster in de wereld staan. Van een verhoogde levenskwaliteit en algemene welzijnsbevordering.Iedereen wordt hier beter van.(https://www.lannoo.be/nl/pijn)

Chronische pijn --- Chronische ziekten --- geneeskunde --- 61 --- 604.3 --- chronische pijn --- pijnbestrijding --- bloeddruk, koorts, pijn, hoofdpijn, rugklachten --- Pijn --- 616.009.7 --- pijn --- Chronic Pain --- Pain Measurement --- Pain, Chronic --- Widespread Chronic Pain --- Chronic Pain, Widespread --- Chronic Pains --- Chronic Pains, Widespread --- Pain, Widespread Chronic --- Pains, Chronic --- Pains, Widespread Chronic --- Widespread Chronic Pains --- Acute Pain --- Analog Pain Scale --- Assessment, Pain --- McGill Pain Scale --- Visual Analog Pain Scale --- Analgesia Tests --- Analogue Pain Scale --- Formalin Test --- McGill Pain Questionnaire --- Nociception Tests --- Pain Assessment --- Tourniquet Pain Test --- Visual Analogue Pain Scale --- Analgesia Test --- Analog Pain Scales --- Analogue Pain Scales --- Assessments, Pain --- Formalin Tests --- Measurement, Pain --- Measurements, Pain --- Nociception Test --- Pain Assessments --- Pain Measurements --- Pain Questionnaire, McGill --- Pain Scale, Analog --- Pain Scale, Analogue --- Pain Scale, McGill --- Pain Scales, Analog --- Pain Scales, Analogue --- Pain Test, Tourniquet --- Pain Tests, Tourniquet --- Questionnaire, McGill Pain --- Scale, Analog Pain --- Scale, Analogue Pain --- Scale, McGill Pain --- Scales, Analog Pain --- Scales, Analogue Pain --- Test, Analgesia --- Test, Formalin --- Test, Nociception --- Test, Tourniquet Pain --- Tests, Analgesia --- Tests, Formalin --- Tests, Nociception --- Tests, Tourniquet Pain --- Tourniquet Pain Tests --- Chronische aandoening --- Chronic pain

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Aversive situations may reduce nociception. The mechanism underlying such analgesia has been suggested to involve the interaction between the two separate but interconnected motivational systems "defense" and "pain." To determine the developmental course of defense and nociception, these processes were analyzed during early ontogeny in rats. To elicit a defensive reaction, a huddle of preweanling rat pups was exposed to an unfamiliar, unrelated adult male, or, for comparison, to the mother. On postnatal Day 7 the pups did not show a behavioral reaction to the presence of the mother or the male, and no reduction in nociceptive threshold in a thermal paw withdrawal test. On Day 14, pups in the presence of the male stopped ongoing behaviors and became immobile, and showed reduced paw withdrawal after the exposure. At Day 21, 22 pups of 32 became immobile when exposed to the male, whereas 10 pups explored the partition separating them from the male. Neither group showed reduced paw withdrawal. Immobility was considered a defensive reaction because it reduces auditory and visual cues and therefore the probability of being detected. The developmental course of immobility seems to reflect both the changes in threat imposed on the pups by a potentially infanticidal male and the ability of pups to react to that threat. The reduction in paw withdrawal that followed male exposure indicates an inhibitory mechanism. It is discussed whether the activation of the defense system results in an inhibition of nociception. (C) 1998 Elsevier Science Inc

Ability. --- Activation. --- Adult. --- Analgesia. --- Auditory. --- Behavior. --- Cues. --- Defense. --- Defensive behavior. --- Defensive. --- Exposure. --- Expression. --- Group. --- Immobility. --- Inhibition. --- Interaction. --- Intrathecal injection. --- Male rat. --- Male. --- Mechanisms. --- Mice. --- Mother. --- Nociception. --- Ontogeny. --- Organization. --- Partition. --- Periaqueductal gray. --- Preweanling rat. --- Preweanling rats. --- Pups. --- Rat. --- Rats. --- Reduction. --- Responses. --- Sex-differences. --- Situations. --- System. --- Systems. --- Test. --- Thermal.