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Gap junctions.
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ISBN: 0845133063 9780845133064 Year: 1988 Volume: 7 Publisher: Liss


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Gap junctions in the brain : physiological and pathological roles
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ISBN: 1283540525 9786613852977 0124159273 012415901X 9780124159273 9780124159013 1283540520 9781283540520 Year: 2012 Publisher: London : Amsterdam : Academic Press ; Elsevier,

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Gap junctions between glial cells or neurons are ubiquitously expressed in the mammalian brain and play a role in brain development including cell differentiation, cell migration and survival, and tissue homeostasis, as well as in human diseases including hearing loss, neuropathies, epilepsy, brain trauma, and cardiovascular disease. This volume provides neuroscience researchers and students with a single source for information covering the physiological, behavioral and pathophysiological roles of gap junctions in the brain. In addition, the book also discusses human disease conditions asso


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Hemichannels; from the molecule to the function
Authors: --- ---
ISBN: 9782889194674 Year: 2015 Publisher: Frontiers Media SA

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Coordinated cell interactions are required to accomplish several complex and dynamic tasks observed in several tissues. Cell function may be coordinated by cell-to-cell communication through gap junctions channels (GJCs). These channels are formed by the serial docking of two hemichannels, which in turn are formed by six protein subunits called connexins (Cxs). It is well known that GJCs are involved in several functions, such as intercellular propagation of calcium waves, spread of electrotonic potentials and spatial buffering of ions and metabolites. On the other hand, undocked hemichannels, which are not forming GJCs, can also serve other functions as “free hemichannels”. Currently, it is recognized that undocked hemichannels may have functional relevance in cell physiology allowing diffusional exchange of ions and small molecules between intra- and extra-cellular compartments. Additionally, another family of proteins calls pannexins (Panx) also forms functional hemichannels at the plasma membrane. Recently, Panxhemichannels have been involved in both pathological and physiological processes. Controlled hemichannel opening allows the release of small signaling molecules including ATP, glutamate, NAD+, adenosine, cyclic nucleotides, PGE2. They also allow uptake of relevant signaling molecules (e.g., cADPR) and metabolites (e.g., glucose). Additionally, a growing body of evidence shows that hemichannels are involved in important processes, such glucose detection in tanicytes, activation of the inflammasome, memory consolidation in the basolateral amygdala, potentiation of muscle contraction and release of nitric oxide from endothelial cells, among others. However, hemichannels can also play an important role in the homeostatic imbalance observed in diverse chronic diseases. In fact, massive and/or uncontrolled hemichannel opening induces or accelerates cell death in several pathological conditions including Charcot-Marie-Tooth disease, ischemia, oculodentodigital dysplasia, hydrotic ectodermic dysplasia, inflammatory responses, and deafness. Hemichannel-mediated cell death is due mainly to an entry of Ca+2. The latter activates proteases, nucleases and lipases, causing irreversible cell damage. An increasing amount of evidence demonstrates that blockade of uncontrolled hemichannel opening greatly reduces the cellular damage observed in several chronic diseases models. Therefore, Cx and Panx-hemichannels appear as promising drug targets for clinical treatment of human chronic diseases. Therefore, pharmacological tools are urgently needed to further elucidate hemichannels functions and to validate them as drug targets for the development of novel therapies for connexin-based diseases. Thus, understanding the role of Cx and Panx-hemichannels under physiological conditions and recognizing the molecular mechanisms controlling them, may provide us with a better picture of the hemichannels participation in some diseases and of the signals underlying their malfunctioning.


Book
Connexins: The Gap Junction Proteins
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ISBN: 8132219198 813221918X 1322173893 Year: 2014 Publisher: New Delhi : Springer India : Imprint: Springer,

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Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins.  The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.

Gap junctions in development and disease
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ISBN: 1280306440 9786610306442 3540286217 3540261567 3642065597 Year: 2005 Publisher: Berlin : Springer-Verlag,

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The main objective of Gap Junctions in Development and Disease is to describe the molecular events that cause impairments in development and disease. Communication between cells via intercellular channels, so called gap junctions, appears to be essential for certain developmental processes and appropriate organ function. Starting with a comprehensive review of the various mouse and human genes encoding the channel-forming protein connexin, further chapters describe the most important connexin mutations that lead to diseases such as hereditary deafness and female infertility in humans. Erroneous signaling mediated via connexin-protein interactions, thought to be responsible for disfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in mice and men, is also addressed. Although the question why some of the mutations in gap-junction proteins lead to a specific phenotype remains to be answered, the reviews in this book give an intriguing outlook on the future direction of this research field.


Book
Gap junction structure and chemical regulation
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ISBN: 0128161507 0128163801 9780128163801 9780128161500 Year: 2019 Publisher: London, United Kingdom

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Gap Junction Structure and Chemical Regulation: Direct Calmodulin Role in Cell-to-Cell Channel Gating describes and discusses the findings of major studies conducted during the past century on the structure and chemical regulation of direct cell-to-cell communication via gap junction channels. Chapters bring together important findings on direct cell communication, from its history, to its structure and regulation. These channels are essential for normal organ function, and mutations in their protein (connexin) cause various diseases. The book is useful for established investigators who need a review on the field and young investigators who need a thorough resource for study and comprehension.

Keywords

Christian shrines --- Christian saints --- Spain --- Cult --- Catholic Church --- Customs and practices. --- Nansa River Valley (Spain) --- Religious life and customs. --- Gap junctions (Cell biology) --- Connexins. --- Calmodulin. --- Gap Junctions --- Cell Communication. --- chemistry. --- Cell Interaction --- Cell-to-Cell Interaction --- Cell Communications --- Cell Interactions --- Cell to Cell Interaction --- Cell-to-Cell Interactions --- Communication, Cell --- Communications, Cell --- Interaction, Cell --- Interaction, Cell-to-Cell --- Interactions, Cell --- Interactions, Cell-to-Cell --- Bovine Activator Protein --- Cyclic AMP-Phosphodiesterase Activator --- Phosphodiesterase Activating Factor --- Phosphodiesterase Activator Protein --- Phosphodiesterase Protein Activator --- Regulator, Calcium-Dependent --- Calcium-Dependent Activator Protein --- Calcium-Dependent Regulator --- AMP-Phosphodiesterase Activator, Cyclic --- Activating Factor, Phosphodiesterase --- Activator Protein, Bovine --- Activator Protein, Calcium-Dependent --- Activator Protein, Phosphodiesterase --- Activator, Cyclic AMP-Phosphodiesterase --- Activator, Phosphodiesterase Protein --- Calcium Dependent Activator Protein --- Calcium Dependent Regulator --- Cyclic AMP Phosphodiesterase Activator --- Factor, Phosphodiesterase Activating --- Protein Activator, Phosphodiesterase --- Protein, Bovine Activator --- Protein, Calcium-Dependent Activator --- Protein, Phosphodiesterase Activator --- Regulator, Calcium Dependent --- Calcium Signaling --- Calcium-dependent activator protein --- Calcium-dependent regulator --- Calcium-binding proteins --- Membrane proteins --- Junctions, Gap (Cell biology) --- Nexus (Cell biology) --- Cell junctions --- Connexins --- Church of Rome --- Roman Catholic Church --- Katholische Kirche --- Katolyt︠s︡ʹka t︠s︡erkva --- Römisch-Katholische Kirche --- Römische Kirche --- Ecclesia Catholica --- Eglise catholique --- Eglise catholique-romaine --- Katolicheskai︠a︡ t︠s︡erkovʹ --- Chiesa cattolica --- Iglesia Católica --- Kościół Katolicki --- Katolicki Kościół --- Kościół Rzymskokatolicki --- Nihon Katorikku Kyōkai --- Katholikē Ekklēsia --- Gereja Katolik --- Kenesiyah ha-Ḳatolit --- Kanisa Katoliki --- כנסיה הקתולית --- כנסייה הקתולית --- 가톨릭교 --- 천주교 --- Nansa Valley (Spain)

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