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Brain --- Neuroprotective agents. --- Trace elements in nutrition. --- Diseases. --- Micronutrients --- Nutrition --- Trace element deficiency diseases --- Neuroprotectants --- Neuroprotective drugs --- Drugs --- Brain diseases --- Psychology, Pathological --- Malalties cerebrals --- Oligoelements en la nutrició

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This book is a critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in both academia and industry; it serves to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently, stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. Divided into five sections, the proposed volume explores historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the most recent bench-side research.

Medicine. --- Neurosciences. --- Cardiology. --- Biomedicine. --- Cerebrovascular disease --- Ischemia. --- Neuroprotective agents. --- Prevention. --- Neuroprotectants --- Neuroprotective drugs --- Ischaemia --- Drugs --- Blood circulation disorders --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences --- Nervous system --- Heart --- Internal medicine --- Diseases

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Nervous system --- Neuropharmacology. --- Neurochemistry. --- Neuroprotective agents --- Parkinson's disease --- Degeneration. --- Degeneration --- Molecular aspects. --- Therapeutic use. --- Pathophysiology. --- Chemotherapy. --- Antiparkinsonian agents --- Palsy, Shaking --- Paralysis agitans --- Parkinson disease --- Parkinsonism --- Shaking palsy --- Brain --- Extrapyramidal disorders --- Neuroprotectants --- Neuroprotective drugs --- Drugs --- Biochemistry --- Neurosciences --- Neurotropic drugs --- Pharmacology --- Organs (Anatomy) --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Diseases --- Drug effects --- Effect of drugs on --- Degeneration and regeneration --- Neurosciences. --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.

Heat shock proteins. --- Nervous system --- Neuroprotective agents. --- Nerve tissue proteins. --- Degeneration. --- Nerve proteins --- Neural proteins --- Neuroproteins --- Proteins --- Stress proteins --- Neuroprotectants --- Neuroprotective drugs --- Drugs --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration (Pathology) --- Degeneration and regeneration --- Neurology. --- Neurosciences. --- Medicine. --- Medical laboratories. --- Human physiology. --- Toxicology. --- Molecular Medicine. --- Laboratory Medicine. --- Human Physiology. --- Pharmacology/Toxicology. --- Human biology --- Medical sciences --- Physiology --- Human body --- Diagnosis, Laboratory --- Health facilities --- Laboratories --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Neural sciences --- Neurological sciences --- Neuroscience --- Medicine --- Neuropsychiatry --- Chemicals --- Pharmacology --- Poisoning --- Poisons --- Diseases --- Toxicology --- Health Workforce --- Neurology . --- Molecular biology. --- Laboratory medicine. --- Pharmacology. --- Drug effects --- Medical pharmacology --- Chemotherapy --- Pharmacy --- Clinical medicine --- Clinical pathology --- Diagnostic laboratory tests --- Laboratory diagnosis --- Laboratory medicine --- Medical laboratory diagnosis --- Diagnosis --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Physiological effect

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Neuroprotection and Regeneration of the Spinal Cord comprehensively covers the most recent research in the field of spinal cord injury. The first part of this book focuses on the latest animal models and clinically oriented work, providing extensive information on morphological factors and, biomechanical analysis, in addition to the mechanism of functional recovery. The book goes on to provide information on clinical relevance introducing analysis of spinal cord injuries using MRI and PET. Edited by renowned experts in the field, this book will provide clinical physicians, basic researchers, and postgraduate students with valuable insight into the cutting-edge research and progress in the field of spinal cord injury, treatment, and repair.                  .

Neuroprotective agents. --- Spinal cord -- Regeneration. --- Spinal cord --- Neuroprotective agents --- Nerve Regeneration --- Spinal Cord Diseases --- Protective Agents --- Physiological Effects of Drugs --- Nervous System Physiological Processes --- Central Nervous System Diseases --- Pharmacologic Actions --- Nervous System Diseases --- Nervous System Physiological Phenomena --- Chemical Actions and Uses --- Musculoskeletal and Neural Physiological Phenomena --- Diseases --- Chemicals and Drugs --- Phenomena and Processes --- Neuroprotective Agents --- Spinal Cord Injuries --- Spinal Cord Regeneration --- Surgery & Anesthesiology --- Health & Biological Sciences --- Surgery - General and By Type --- Regeneration --- Regeneration. --- Neuroprotectants --- Neuroprotective drugs --- Medicine. --- Neurology. --- Neurosurgery. --- Orthopedics. --- Otolaryngologic surgery. --- Medicine & Public Health. --- Surgical Orthopedics. --- Head and Neck Surgery. --- Drugs --- Orthopedic surgery. --- Head --- Surgery. --- Nerves --- Neurosurgery --- Medicine --- Nervous system --- Neuropsychiatry --- Operative orthopedics --- Orthopedics --- Surgery, Operative --- Orthopaedics --- Orthopedia --- Surgery --- Neurology . --- Operative otolaryngology --- Otolaryngologic surgery --- Surgery, Orificial