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While the incidence rate of neuroendocrine tumours has been increasing, the survival rate has not. Therefore, there is a great need for state-of-the-art research and new treatment protocols. The chapters in this book contribute to that debate and will be required reading for both researchers and healthcare practitioners, as it offers both overviews of the condition and specialized contributions. Topics covered include the association between chronic inflammation and gastroenteropancreatic neuroendocrine tumours, or GEP-NETs. GEP-NETs are also addressed in a chapter on their circulating markers, which can help in diagnosing this hard to detect condition. One chapter covers the role of Chromogranin A, while another addresses the diagnosis and management of neuroendocrine carcinomas in cases where the primary site is unknown.
Neuroendocrine tumors. --- Tumors --- Oncology
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Présentation de l'éditeur : "Les tumeurs du grêle étant de loin les plus fréquentes, une large partie de ce rapport leur est consacré. Les tumeurs du grêle ont ceci de particulier qu'elles sont souvent rencontrées fortuitement lors d'une intervention pour occlusion intestinale, donc par tout chirurgien digestif de garde, le plus souvent non spécialisé dans ce type de tumeurs. Ces lésions présentent des caractères spécifiques influant sur la prise en charge thérapeutique : syndrome carcinoïde éventuel, caractère très différencié le plus souvent d'évolution lente, caractère multiple, parfois familial, atteinte ganglionnaire mésentérique entrainant la bien connue mésentérite rétractile pouvant imposer des résections intestinales larges. Ce rapport aborde tous ces points et offre au lecteur l'expérience des praticiens les plus expérimentés en France dans des domaines aussi variés que l'anatomo-pathologie, les aspects médicaux et surtout chirurgicaux. Les techniques d'exérèse des lésions, de curage ganglionnaire et de résection de grêle sont ici exposées."
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This atlas provides descriptive information on the cytopathology of neuroendocrine tumor types and differential diagnoses. It addresses the wide distribution of the neuroendocrine cells in the body and provides detailed descriptions of the morphologic spectrum of the neoplasms (including different terminologies), and their immunocytohistochemical properties, associated ultrastructural findings, secretory products, and their association with many hereditary syndromes.
Endocrine glands --- Tumors. --- Cytodiagnosis --- Neuroendocrine tumors
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Endocrine and neuroendocrine tumors originate from endocrine cells but are heterogeneous in terms of clinical presentation, disease outcome, and treatments available. This Special Issue addresses specific aspects of pre-clinical, clinical, and translational research and clinical management of these diseases with the aim of providing novel insights, addressing current unmet needs, and discussing future treatment perspectives.
Neuroendocrine tumors. --- Neuroendocrinology. --- Endocrinology --- Neurology --- Neurohormones --- Tumors
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Gastroenteropancreatic neuroendocrine tumors are considered rare diseases according to the Surveillance Epidemiology. However their incidences are subject to a constant increase. On the other hand, the medical profession possesses a medicinal arsenal to counter such illness gradually more specific and Jess harmful treatments penetrated the market. Among these treatments, metabolic radiotherapy will be analyzed through this essay. From non- selective approaches such as chemotherapy and surgery to selective approaches such as somatostatine analogues, we will determine the appropriate place of metabolic radiotherapy between these therapies. Les tumeurs Neuroendocrines gastro-entéro-pancréatiques sont considérées comme maladie rare par The US Surveillance Epidemiology. Cependant, leur incidence est en constante augmentation. Peu à peu, des traitements plus spécifiques et moins nocifs sont apparus sur le marché. Parmi ces traitements, nous allons analyser la radiothérapie métabolique. Effectivement, par son mécanisme d'action novateur, elle permet une approche ciblée et efficace. Cependant, le corps médical dispose de tout un arsenal thérapeutique. Passant par des approches non sélectives comme la chimiothérapie et la chirurgie à des approches sélectives comme les simples analogues à la somatostatine, nous allons déterminer quelle est la place de la radiothérapie métabolique parmi ces thérapies.
Radiotherapy --- Neuroendocrine Tumors --- Pancreatic Neoplasms --- Stomach Neoplasms
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The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.
Melanoma. --- Malignant melanoma --- Melanocytic tumor --- Cancer --- Neuroendocrine tumors --- Oncology
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Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.
Melanoma --- Treatment. --- Malignant melanoma --- Melanocytic tumor --- Cancer --- Neuroendocrine tumors --- Oncology
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This book provides an excellent overview of how melanoma is treated in the clinic. Since oncologists and clinicians across the globe contributed to this book, each area also explores the unique burdens that geographical areas experience from melanoma subtypes and how these are treated in different settings. It also includes several chapters that illustrate novel methods for diagnosing melanoma in the clinic using new technologies, which are likely to significantly improve outcomes. Several chapters cover surgical techniques and other present very rare or challenging clinical cases of melanoma and how these were treated. The book is geared towards informing clinicians and even patients how melanoma arises, what tools are available and which decisions need to be made by patients and their families in order to treat this devastating disease.
Melanoma. --- Malignant melanoma --- Melanocytic tumor --- Cancer --- Neuroendocrine tumors --- Oncology
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