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Serine proteases and their serpin inhibitors in the nervous system : regulation in development and in degenerative and malignant disease : proceedings of a NATO advanced research workshop on regulation of extravascular fibrinolysis in nervous system development and disease, held July 2-8, 1989, in Maratea
ISBN: 0306435845 Year: 1990 Publisher: New York London Plenum


Book
Clinical neuroanatomy : brain circuitry and its disorders
Authors: ---
ISBN: 3642191339 3642191347 Year: 2011 Publisher: New York : Springer,

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Abstract

Connections define the functions of neurons: information flows along connections, as well as growth factors and viruses, and even neuronal death may progress through connections. Knowledge of how the various parts of the brain are interconnected to form functional systems is a prerequisite for the proper understanding of data from all fields in the neurosciences. Clinical Neuroanatomy: Brain Circuitry and Its Disorders bridges the gap between neuroanatomy and clinical neurology. It emphasizes human and primate data in the context of disorders of brain circuitry which are so common in neurological practice. In addition, numerous clinical cases demonstrate how normal brain circuitry may be interrupted and to what effect. Following an introduction into the organization and vascularisation of the human brain and the techniques to study brain circuitry, the main neurofunctional systems are discussed, including the somatosensory, auditory, visual, motor, antonomic and limbic systems, the cerebral cortex and complex cerebral functions.

Neuroscience in medicine
Author:
ISBN: 1588290166 1475759754 9786610842490 1280842490 1592593712 Year: 2003 Publisher: Totowa (N.J.) Humana Press

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Enormous progress has been made in understanding the brain at the molecular, anatomic, and physiological levels in the years following the "Decade of the Brain," with the results providing insight into the underlying basis of many neurological disease processes. In Neuroscience in Medicine, Second Edition, P. Michael Conn and a distinguished panel of basic and clinical investigators noted for their teaching excellence have thoroughly updated and revised their classic first edition to reflect these remarkable advances. Designed specifically for medical students and allied health professionals, the book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relate that science to the understanding of neurological disorders and their treatment. These popular "clinical correlations" cover, in detail, disorders of the spinal cord, neuronal migration, the autonomic nervous system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, and myasthenia gravis. Materials new to this revised edition include full chapters on the thalamus, pain, immune system interactions with the nervous system, and the anatomy of the spinal cord and brain. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the book summarizes up-to-date findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Neuroscience in Medicine, Second Edition provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as clearly demonstrating their emerging diagnostic and therapeutic importance.

Inflammatory disorders of the nervous system : pathogenesis, immunology, and clinical management
Authors: ---
ISBN: 9781588294241 1588294242 9781592599059 1617375608 9786610359202 128035920X 1592599052 Year: 2005 Publisher: Totowa, N.J. : Humana Press,

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Abstract

Now well recognized, the critical role of the inflammatory response in the pathophysiology of peripheral and central neurological disorders, including Alzheimer's and Parkinson's diseases, is today the subject of intense investigation at the molecular level. In Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management, a panel of influential basic scientists review in detail the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidosis, HIV-associated dementia, and HTLV-associated neurological disorders. Cutting-edge and authoritative, Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management offers basic research and clinical scientists an illuminating introduction to the new world of inflammatory CNS conditions and the emerging diagnostic and therapeutic opportunities they provide.

Markers of neuronal injury and degeneration
Author:
ISBN: 0897667964 0897667956 9780897667968 9780897667951 Year: 1993 Volume: 679 Publisher: New York (N.Y.) : New York academy of sciences,


Book
Store-operated Ca2+ entry (SOCE) pathways : emerging signaling concepts in human (PATHO)physiology
Authors: --- ---
ISBN: 3709109612 3709116821 3709109620 1280787090 9786613697486 Year: 2012 Publisher: Wien ; New York : Springer,

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Abstract

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

Keywords

Nervous system -- Cytopathology. --- Nervous system -- Pathophysiology. --- Robotics in medicine. --- Calcium channels --- Cellular signal transduction --- Intracellular calcium --- Ion Transport --- Second Messenger Systems --- Biology --- Pathologic Processes --- Pathological Conditions, Signs and Symptoms --- Signal Transduction --- Biological Transport --- Biological Science Disciplines --- Cell Physiological Processes --- Biochemical Processes --- Metabolism --- Diseases --- Natural Science Disciplines --- Cell Physiological Phenomena --- Disciplines and Occupations --- Chemical Processes --- Metabolic Phenomena --- Biochemical Phenomena --- Phenomena and Processes --- Chemical Phenomena --- Calcium Signaling --- Disease --- Genetics --- Human Anatomy & Physiology --- Health & Biological Sciences --- Biophysics --- Animal Biochemistry --- Calcium channels. --- Cellular signal transduction. --- Intracellular calcium. --- Cellular calcium --- Cellular information transduction --- Information transduction, Cellular --- Signal transduction, Cellular --- Channels, Calcium --- Medicine. --- Human physiology. --- Molecular biology. --- Cardiology. --- Cell biology. --- Biomedicine. --- Molecular Medicine. --- Cell Biology. --- Human Physiology. --- Biological and Medical Physics, Biophysics. --- Calcium in the body --- Second messengers (Biochemistry) --- Bioenergetics --- Cellular control mechanisms --- Information theory in biology --- Ion channels --- Cytology. --- Heart --- Internal medicine --- Human biology --- Medical sciences --- Physiology --- Human body --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Health Workforce --- Biophysics. --- Biological physics. --- Biological physics --- Physics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology

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