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This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.

Cellular signal transduction. --- Nervous system --Degeneration --Pathophysiology. --- Proteins --Physiological transport. --- Nervous system --- Proteins --- Cellular signal transduction --- Biological Transport --- Biochemical Processes --- Nervous System Diseases --- Cell Physiological Processes --- Biological Science Disciplines --- Diseases --- Natural Science Disciplines --- Chemical Processes --- Biochemical Phenomena --- Cell Physiological Phenomena --- Metabolism --- Chemical Phenomena --- Disciplines and Occupations --- Phenomena and Processes --- Metabolic Phenomena --- Protein Transport --- Physiology --- Signal Transduction --- Neurodegenerative Diseases --- Medicine --- Health & Biological Sciences --- Neurology --- Degeneration --- Pathophysiology --- Physiological transport --- Biological transport. --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Membrane transport --- Passive transport, Biological --- Transport, Biological --- Degeneration and regeneration --- Medicine. --- Neurosciences. --- Biomedicine. --- Degeneration (Pathology) --- Diffusion --- Osmosis --- Neural sciences --- Neurological sciences --- Neuroscience --- Medical sciences

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The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Nervous system -- Degeneration -- Etiology. --- Nervous system -- Degeneration -- Pathophysiology. --- Nervous system -- Degeneration -- Treatment. --- Neurodegenerative diseases -- Therapy. --- Protein folding. --- Proteins -- Conformation. --- Nervous system --- Metabolic Phenomena --- Nervous System Diseases --- Proteins --- Medicine --- Molecular Conformation --- Metabolic Diseases --- Amino Acids, Peptides, and Proteins --- Nutritional and Metabolic Diseases --- Phenomena and Processes --- Molecular Structure --- Health Occupations --- Diseases --- Disciplines and Occupations --- Chemicals and Drugs --- Biochemical Phenomena --- Chemical Phenomena --- Neurodegenerative Diseases --- Protein Conformation --- Pathology --- Proteome --- Metabolism --- Proteostasis Deficiencies --- Health & Biological Sciences --- Neurology --- Degeneration --- Degeneration. --- Degeneration, Nerve --- Nerve degeneration --- Nervous system degeneration --- Neurodegenerative disease --- Neurodegenerative diseases --- Neurodegenerative disorders --- Neuron degeneration --- Nissl degeneration --- Retrograde degeneration --- Wallerian degeneration --- Degeneration and regeneration --- Medicine. --- Molecular biology. --- Neurosciences. --- Neurochemistry. --- Biomedicine. --- Molecular Medicine. --- Degeneration (Pathology) --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biochemistry --- Neurosciences --- Neural sciences --- Neurological sciences --- Neuroscience --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biophysics --- Biomolecules --- Systems biology