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Plus que jamais, les oncologues ont besoin de l’apport de la biologie, d’abord pour comprendre les cancers, mais surtout pour les traiter. Des milliers d’essais thérapeutiques ont été lancés pour évaluer les thérapies innovantes ciblant les mécanismes de l’oncogenèse. Il est maintenant bien établi que le cancer est, d’une certaine façon, une maladie de la signalisation cellulaire : les cellules cancéreuses détournent à leur profit les messages que s’échangent les cellules, masquent ou surexpriment les récepteurs de ces messages, miment de mille façons les voies intracellulaires qui leur permettent de proliférer et d’envahir les tissus voisins ou distants.Afin de ne pas se perdre dans le dédale des voies de signalisation, dans la profusion des récepteurs et des signaux concourant à l’oncogenèse, cet ouvrage propose une vision d’ensemble, simplifiée, didactique et complète des voies de transmission de l’information entre les cellules et à l’intérieur des cellules. Les voies de signalisation sont analysées une à une, mais sans jamais esquiver la complexité de leurs interconnexions. La présentation de chaque voie est suivie d’une brève description des altérations rencontrées dans les cancers et des approches pharmacologiques ciblées qui peuvent être mises en œuvre pour y remédier. Les mécanismes de base de la biologie moléculaire, qui permettent d’expliquer les perturbations des voies de signalisation, font l’objet d’annexes didactiques.Cette nouvelle édition intègre les découvertes récentes de la recherche et apporte des compléments sur des sujets qui n’avaient pas été abordés dans la première édition, en particulier un chapitre sur adhésion et motilité cellulaire et une annexe sur les déviations métaboliques des cellules cancéreuses. Abondamment illustré par des schémas très précis, cet ouvrage sera le compagnon idéal de l’oncologue dans sa quête de nouvelles thérapeutiques anticancéreuses.

Neoplastic cells, Circulating --- Neoplasms --- Stem cells --- Cellules cancéreuses --- Cellules souches --- Cellular signal transduction --- Carcinogenesis --- Cancer cells --- Signal Transduction --- Proliferation --- Neoplasms. --- Neoplastic Cells, Circulating. --- Signal Transduction. --- Stem Cells. --- Cellules cancéreuses. --- Cellules souches.

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Biologie cellulaire --- Cancer --- Celbiologie --- Kanker --- Cell Movement. --- Neoplastic Cells, Circulating. --- Neoplasm Invasiveness. --- Neoplasm Metastasis. --- Cancer cells --- -Cells --- -Organisms --- Cytology --- Cells --- Pathology, Cellular --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastasis --- Metastases --- Neoplasms --- Neoplasm Invasion --- Invasiveness, Neoplasm --- Invasion, Neoplasm --- Cells, Neoplasm Circulating --- Circulating Cells, Neoplasm --- Circulating Tumor Cells --- Circulating Neoplastic Cells --- Embolic Tumor Cells --- Embolism, Tumor --- Neoplasm Circulating Cells --- Tumor Cells, Embolic --- Cell, Circulating Neoplastic --- Cell, Circulating Tumor --- Cell, Embolic Tumor --- Cell, Neoplasm Circulating --- Cells, Circulating Neoplastic --- Cells, Circulating Tumor --- Cells, Embolic Tumor --- Circulating Neoplastic Cell --- Circulating Tumor Cell --- Embolic Tumor Cell --- Embolisms, Tumor --- Neoplasm Circulating Cell --- Neoplastic Cell, Circulating --- Tumor Cell, Circulating --- Tumor Cell, Embolic --- Tumor Cells, Circulating --- Tumor Embolism --- Tumor Embolisms --- Cell Migration --- Locomotion, Cell --- Migration, Cell --- Motility, Cell --- Movement, Cell --- Cell Locomotion --- Cell Motility --- Cell Movements --- Movements, Cell --- Cell Tracking --- Congresses --- Motility --- -Congresses --- secondary --- Cell Movement --- Neoplasm Invasiveness --- Neoplasm Metastasis --- Neoplastic Cells, Circulating --- Organisms --- Motility&delete& --- Metastase

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Tumor markers --- Diagnostic use. --- Molecular diagnosis --- Neoplastic Cells, Circulating. --- Liquid Biopsy. --- Cytodiagnosis. --- Cytodiagnoses --- Cytological Techniques --- Liquid Biopsies --- Biopsies, Liquid --- Biopsy, Liquid --- Cell-Free Nucleic Acids --- Blood Specimen Collection --- Cells, Neoplasm Circulating --- Circulating Cells, Neoplasm --- Circulating Tumor Cells --- Circulating Neoplastic Cells --- Embolic Tumor Cells --- Embolism, Tumor --- Neoplasm Circulating Cells --- Tumor Cells, Embolic --- Cell, Circulating Neoplastic --- Cell, Circulating Tumor --- Cell, Embolic Tumor --- Cell, Neoplasm Circulating --- Cells, Circulating Neoplastic --- Cells, Circulating Tumor --- Cells, Embolic Tumor --- Circulating Neoplastic Cell --- Circulating Tumor Cell --- Embolic Tumor Cell --- Embolisms, Tumor --- Neoplasm Circulating Cell --- Neoplastic Cell, Circulating --- Tumor Cell, Circulating --- Tumor Cell, Embolic --- Tumor Cells, Circulating --- Tumor Embolism --- Tumor Embolisms --- Biòpsia --- Citodiagnòstic. --- Cèl·lules canceroses --- Citologia clínica --- Diagnòstic cel·lular --- Diagnòstic citològic --- Diagnòstic citopatòlogic --- Diagnòstic citoquímic --- Diagnòstic histocitològic --- Diagnostic històlogic --- Diagnòstic de laboratori --- Biòpsia per aspiració --- Histopatologia --- Patologia cel·lular --- Cirurgia operatòria --- Cèl·lules --- Metàstasi --- Càncer

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This book compiles the latest research and key findings about the role of circulating tumor cells (CTCs) in Breast Cancer progression, both from the research and clinical standpoint. Based on latest advancements, the content of the book is set out to provide a clear overview about the biology and use of CTCs as a tool for the monitoring and management of breast cancer patients. This work covers basic concepts about the process of metastasis, the biology of CTCs and their potential applications as a biomarker in breast cancer. It will enable readers to delve into the process of epithelial-mesenchymal plasticity (EMP), mechanisms and clinical implications of tumor cell dormancy and minimal residual disease, and into the phenotypical and molecular heterogeneity of CTCs and CTC clusters, including the epigenetic characterization of CTCs. Readers will find out about the key technologies used for the isolation of CTCs as well as the latest advances towards the characterization of CTCs, involving single cell analyses and patient-derived models. It will discuss the evidences about the use of CTCs as a tool to monitor breast cancer progression and therapy response, as well as to unravel mechanisms of resistance to therapy and to identify new therapeutic targets favoring the development of novel anticancer drugs. Lastly, it will discuss ongoing clinical trials and try to foresee the future of CTCs in terms of clinical application and implementation in the clinical routine. The topic of this book is particularly relevant for cancer researchers and oncologist with an interest in the field, looking to refresh or to broaden their knowledge and understanding about the use of CTCs as a diagnostic biomarker in breast cancer.

Cancer research. --- Molecular biology. --- Biomedical engineering. --- Stem cells. --- Cancer Research. --- Molecular Medicine. --- Biomedical Engineering/Biotechnology. --- Stem Cells. --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Clinical engineering --- Medical engineering --- Bioengineering --- Biophysics --- Engineering --- Medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology --- Cancer research --- Breast --- Breast Neoplasms. --- Neoplasm Metastasis. --- Neoplastic Cells, Circulating. --- Cancer --- Molecular aspects. --- Cells, Neoplasm Circulating --- Circulating Cells, Neoplasm --- Circulating Tumor Cells --- Circulating Neoplastic Cells --- Embolic Tumor Cells --- Embolism, Tumor --- Neoplasm Circulating Cells --- Tumor Cells, Embolic --- Cell, Circulating Neoplastic --- Cell, Circulating Tumor --- Cell, Embolic Tumor --- Cell, Neoplasm Circulating --- Cells, Circulating Neoplastic --- Cells, Circulating Tumor --- Cells, Embolic Tumor --- Circulating Neoplastic Cell --- Circulating Tumor Cell --- Embolic Tumor Cell --- Embolisms, Tumor --- Neoplasm Circulating Cell --- Neoplastic Cell, Circulating --- Tumor Cell, Circulating --- Tumor Cell, Embolic --- Tumor Cells, Circulating --- Tumor Embolism --- Tumor Embolisms --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastasis --- Metastases --- Neoplasms --- Breast Carcinoma --- Cancer of the Breast --- Human Mammary Carcinoma --- Malignant Neoplasm of Breast --- Malignant Tumor of Breast --- Mammary Cancer --- Mammary Carcinoma, Human --- Mammary Neoplasm, Human --- Mammary Neoplasms, Human --- Neoplasms, Breast --- Tumors, Breast --- Breast Cancer --- Breast Tumors --- Cancer of Breast --- Breast Carcinomas --- Breast Malignant Neoplasm --- Breast Malignant Neoplasms --- Breast Malignant Tumor --- Breast Malignant Tumors --- Breast Neoplasm --- Breast Tumor --- Cancer, Breast --- Cancer, Mammary --- Cancers, Mammary --- Carcinoma, Breast --- Carcinoma, Human Mammary --- Carcinomas, Breast --- Carcinomas, Human Mammary --- Human Mammary Carcinomas --- Human Mammary Neoplasm --- Human Mammary Neoplasms --- Mammary Cancers --- Mammary Carcinomas, Human --- Neoplasm, Breast --- Neoplasm, Human Mammary --- Neoplasms, Human Mammary --- Tumor, Breast --- Breast Cancer Lymphedema --- secondary --- Càncer de mama --- Cèl·lules canceroses --- Monitoratge de pacients --- Monitoratge fisiològic --- Supervisió electrònica dels malalts --- Supervisió electrònica dels pacients --- Diagnòstic --- Medicina intensiva --- Monitoratge fetal --- Cèl·lules --- Patologia cel·lular --- Metàstasi --- Càncer --- Càncer de pit --- Malalties de la mama --- Càncer ginecològic --- Research.