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Antigens, Neoplasms - congresses. --- Neoplasms - immunology - congresses.

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Tumor antigens --- Immunotherapy --- Neoplasms --- immunology --- Therapeutic immunology --- Clinical immunology --- Therapeutics --- Antigens --- Tumor markers --- immunology. --- Cancer --- Carcinogenesis --- Immunological aspects --- Neoplasms - immunology

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Monoclonal antibodies --- Antibodies, Monoclonal --- Neoplasms --- Therapeutic use --- Diagnostic use --- immunology --- Anticorps monoclonal --- monoclonal antibodies --- Immunologie --- Immunology --- Immunoglobuline --- Immunoglobulins --- 616-097 --- -Monoclonal antibodies --- -577.27 --- biochemie --- geneeskunde --- hematologie --- histologie --- immunologie --- microbiologie --- oncologie --- Monoclonal immunoglobulins --- Molecular cloning --- immunology. --- Antigens. Antibodies --- 616-097 Antigens. Antibodies --- 577.27 --- Monoclonal antibodies - Therapeutic use --- Monoclonal antibodies - Diagnostic use --- Antibodies, Monoclonal - immunology --- Neoplasms - immunology --- Biologie cellulaire

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Major scientific advances in molecular and clinical immunology have produced tremendous growth in our understanding of how cancer is recognized by the immune system, as well as in our ability to control and modulate that recognition. In Immunotherapy of Cancer, expert bench and clinical scientists join forces to concurrently review both the state of the art in tumor immunology and its clinical translation into promising practical treatments. The authors explain in each chapter the scientific basis behind such therapeutic agents as monoclonal antibodies, cytokines, vaccines, and T-cells, and illustrate their clinical manipulation to combat cancer. Additional chapters address statistical analysis-both of clinical trials and assay evaluations-methods for the discovery of antigens, adoptive T-cell therapy, and adaptive and innate immunity. The challenges in clinical trial design, the need for biomarkers of response-such as novel imaging techniques and immunological monitoring-and the new advances and directions in cancer immunotherapy are also fully examined. Comprehensive and cutting-edge, Immunotherapy of Cancer offers immunologists an exhaustive and authoritative survey of cancer immunotherapy, as well as providing a springboard for applying the most important findings in tumor immunology to any basic laboratory program or clinical oncology practice.

Neoplasms. --- Antineoplastic Agents. --- Immunotherapy. --- Cancer --- Antineoplastic agents --- Anticancéreux --- Design. --- Immunothérapie --- Conception --- Antineoplastic agents -- Design. --- Cancer -- Immunotherapy. --- Neoplasms -- immunology. --- Neoplasms -- therapy. --- Neoplasms --- Immunotherapy --- Immunomodulation --- Diseases --- Biological Therapy --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Oncology --- Medicine --- Health & Biological Sciences --- Design --- Anticancer agents --- Antineoplastic drugs --- Antineoplastics --- Antitumor agents --- Antitumor drugs --- Cytotoxic drugs --- Inhibitors, Neoplasm --- Neoplasm inhibitors --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Drugs --- Chemotherapy --- Immunological aspects --- Treatment --- immunology. --- therapy.

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The recent FDA approval of Provenge® as the first therapeutic cancer vaccine together with the recent demonstration that Ipilimumab®, a monoclonal antibody that blocks the negative immune checkpoint cytotoxic T lymphocyte associated antigen-4, prolongs patient survival are major achievements that usher in a new era of cancer immunotherapy. These “first-in-class” treatments reflect the substantive progress that basic and translational scientists have made towards understanding the mechanisms underlying protective tumor immunity in cancer patients Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy.

Immunology -- Periodicals. --- Immunology. --- Immunotherapy -- Periodicals. --- Immunotherapy. --- Neoplasms -- immunology -- Periodicals. --- Neoplasms -- therapy -- Periodicals. --- Cancer --- Immunomodulation --- Diseases --- Biological Therapy --- Therapeutics --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Immunotherapy --- Neoplasms --- Medicine --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Oncology --- Immunological aspects --- Immunological aspects. --- Therapeutic immunology --- Carcinogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Immunobiology --- Life sciences --- Serology --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Medical sciences --- Pathology --- Physicians --- Clinical immunology --- Oncology. --- Tumors