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Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.

Cancer -- Molecular aspects -- Congresses. --- Molecular Biology -- Methods -- Congresses. --- Neoplasms -- Genetics -- Congresses. --- Tumors --- Genomics --- Cancer --- Biology --- Diseases --- Computational Biology --- Genetics --- Neoplasms --- Biological Science Disciplines --- Natural Science Disciplines --- Disciplines and Occupations --- Medicine --- Oncology --- Health & Biological Sciences --- Genetic aspects --- Immunology --- Carcinogenesis. --- Oncology. --- Oncogenesis --- Pathogenesis of cancer --- Tumorigenesis --- Pathogenesis --- Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Pathology --- Genetic toxicology --- Oncology  . --- Cancer research

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Principles and Practice of Cancer Infectious Diseases is a comprehensive and insightful work dedicated to elucidating the problem of infections in cancer patients. This essential volume reviews common and less often encountered infections, while establishing the difficulties behind preventing, diagnosing, and treating infectious diseases in cancer patients. Key sections are devoted to the presentation of clinical symptoms and the identification of major etiologic agents. A cadre of leading clinicians provide a detailed assessment of the risk factors for various infections, critical strategies in preventing and managing infections, and study of the interactions between the pathogen and host's immune function and inflammatory response. With its in-depth knowledge and concise treatment of the distinct facets of infections in cancer patients, this volume is an indispensable tool for all infectious disease specialists and clinical oncologists.

Cancer -- Complications. --- Cancer -- Genetic aspects. --- Infection -- Treatment. --- Neoplasms -- genetics -- Congresses. --- Cancer --- Infection --- Investigative Techniques --- Bacterial Infections and Mycoses --- Diseases --- Biology --- Public Health Practice --- Biological Science Disciplines --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Public Health --- Natural Science Disciplines --- Environment and Public Health --- Health Care --- Disciplines and Occupations --- Methods --- Communicable Diseases --- Communicable Disease Control --- Neoplasms --- Microbiology --- Virology --- Medicine --- Health & Biological Sciences --- Oncology --- Infectious Diseases --- Complications --- Treatment --- Infection. --- Complications. --- Infectious diseases --- Complications and sequelae --- Medicine. --- Internal medicine. --- Hematology. --- Infectious diseases. --- Oncology. --- Medicine & Public Health. --- Infectious Diseases. --- Internal Medicine. --- Tumors --- Haematology --- Internal medicine --- Blood --- Medicine, Internal --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Medical microbiology --- Causes and theories of causation --- Emerging infectious diseases. --- Oncology  . --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases