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This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology. .

Hematology. --- Oncology  . --- Oncology. --- Haematology --- Internal medicine --- Blood --- Tumors --- Diseases --- Blood Diseases. --- Hematologic Diseases. --- Hematopoiesis. --- Neoplasms, Plasma Cell. --- Plasma Cell Neoplasms --- Neoplasm, Plasma Cell --- Plasma Cell Neoplasm --- Haematopoiesis --- Hematopoiesis, Medullary --- Medullary Hematopoiesis --- Hematological Diseases --- Blood Diseases --- Blood Disease --- Disease, Blood --- Disease, Hematologic --- Disease, Hematological --- Diseases, Blood --- Diseases, Hematologic --- Diseases, Hematological --- Hematologic Disease --- Hematological Disease --- Hematology

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This state-of-the-art book is written by a group of international experts to provide insight into the newest breakthroughs from basic pathogenesis to clinical aspects of multiple myeloma. The book provides a comprehensive overview of the genetic and molecular epidemiology of multiple myeloma in order to get a more refined and conclusive understanding of this disease.  Areas, which are covered include the characterization of different myeloma entities by genomics and proteomics, notch signaling and targeting protein translation as a new treatment for multiple myeloma, cell cycle control of plasma cell differentiation, the role of bone disease in the pathogenesis of multiple myeloma as well as the molecular interaction of multiple myeloma with a microenvironment. Genetic and Molecular Epidemiology of Multiple Myeloma is a valuable resource for cancer researchers, medical, surgical, and radiation oncologists.

Cell differentiation. --- Cytology. --- Human genetics. --- Medicine. --- Neoplasms -- Epidemiology. --- Neoplasms -- Prevention & control. --- Oncology. --- Multiple myeloma --- Biology --- Neoplasms, Plasma Cell --- Neoplasms by Histologic Type --- Biological Science Disciplines --- Neoplasms --- Natural Science Disciplines --- Disciplines and Occupations --- Diseases --- Genetics --- Multiple Myeloma --- Medicine --- Health & Biological Sciences --- Oncology --- B cells --- Epidemiology. --- Tumors. --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Kahler's disease --- Plasma cell myeloma --- Cancer research. --- Cell biology. --- Biomedicine. --- Cancer Research. --- Cell Biology. --- Human Genetics. --- Lymphomas --- Monoclonal gammopathies --- Plasmacytoma --- Tumors --- Heredity, Human --- Human biology --- Physical anthropology --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Cancer research

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Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy. In particular, the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide means that multiple myeloma now stands at the forefront of advances in oncology drug development. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

B cells -- Tumors. --- Multiple myeloma. --- Multiple myeloma --- Hemostatic Disorders --- Lymphoproliferative Disorders --- Paraproteinemias --- Neoplasms, Plasma Cell --- Blood Protein Disorders --- Immunoproliferative Disorders --- Vascular Diseases --- Neoplasms by Histologic Type --- Hemorrhagic Disorders --- Hematologic Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Neoplasms --- Hemic and Lymphatic Diseases --- Diseases --- Multiple Myeloma --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- B cells --- Tumors. --- B cell neoplasia --- B cell neoplasms --- B cell tumors --- B lymphocyte tumors --- Kahler's disease --- Plasma cell myeloma --- Medicine. --- Cancer research. --- Hematology. --- Oncology. --- Medicine & Public Health. --- Cancer Research. --- Tumors --- Haematology --- Internal medicine --- Blood --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Lymphomas --- Monoclonal gammopathies --- Plasmacytoma --- Oncology  .

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Granulocyte colony-stimulating factor (G-CSF or GCSF) is a secreted glycoprotein that stimulates the proliferation and differentiation of granulocyte precursor cells, and induces mobilization of peripheral blood progenitor cells from the bone marrow. Development of recombinant human G-CSF has had a profound impact on the treatment of many diseases, including severe chronic neutropenia and cancer, and has enabled peripheral stem cell transplantation to supplant bone marrow transplantation in the autologous setting. This Milestones in Drug Therapy volume describes the experience of the last 20 years of treatment with recombinant human G-CSF, including the basic science, the use of recombinant human G-CSF in both the oncology and nononcology settings, and the safety and economics of its use. Many of the authors were the original investigators of recombinant human G-CSF and other authors are key researchers who provide their outlook for the next 20 years for use of and research with recombinant human G-CSF.

Drug abuse -- Etiology -- Handbooks, manuals, etc. --- Drug abuse -- Psychological aspects -- Handbooks, manuals, etc. --- Filgrastim --- Colony-Stimulating Factors --- Leukemia --- Neoplasms, Plasma Cell --- Receptors, Colony-Stimulating Factor --- Lymphoproliferative Disorders --- Hematologic Diseases --- Hemostatic Disorders --- Therapeutics --- Paraproteinemias --- Hemorrhagic Disorders --- Hematopoietic Cell Growth Factors --- Receptors, Cytokine --- Immunoproliferative Disorders --- Neoplasms by Histologic Type --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Receptors, Growth Factor --- Hemic and Lymphatic Diseases --- Blood Protein Disorders --- Glycoproteins --- Vascular Diseases --- Cytokines --- Proteins --- Receptors, Peptide --- Neoplasms --- Receptors, Immunologic --- Diseases --- Immune System Diseases --- Cardiovascular Diseases --- Receptors, Cell Surface --- Amino Acids, Peptides, and Proteins --- Intercellular Signaling Peptides and Proteins --- Membrane Proteins --- Chemicals and Drugs --- Biological Factors --- Peptides --- Multiple Myeloma --- Granulocyte Colony-Stimulating Factor --- Drug Therapy --- Leukocyte Disorders --- Leukemia, Myeloid --- Receptors, Granulocyte Colony-Stimulating Factor --- Health & Biological Sciences --- Biology --- Pharmacy, Therapeutics, & Pharmacology --- Microbiology & Immunology --- Granulocyte-macrophage colony-stimulating factor. --- Colony-stimulating factors (Physiology) --- Granulocytes. --- Macrophages. --- Histiocytes --- Mononuclear phagocytes --- Granular leucocytes --- CSF-GM (Colony-stimulating factor) --- GM-CSF (Colony-stimulating factor) --- Histamine-producing cell-stimulating factor --- Medicine. --- Cancer research. --- Immunology. --- Pharmacology. --- Hematology. --- Cytokines. --- Growth factors. --- Biomedicine. --- Pharmacology/Toxicology. --- Cancer Research. --- Cytokines and Growth Factors. --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Phagocytes --- Reticulo-endothelial system --- Leucocytes --- Hematopoietic growth factors --- Toxicology. --- Oncology. --- Haematology --- Internal medicine --- Blood --- Cellular immunity --- Immune response --- Immunobiology --- Life sciences --- Serology --- Tumors --- Chemicals --- Medicine --- Pharmacology --- Poisoning --- Poisons --- Regulation --- Toxicology --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cancer research --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemotherapy --- Drugs --- Pharmacy --- Physiological effect

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This book provides a comprehensive and up-to-date overview of the pathologic features of common benign and malignant hematopoietic disorders in spleen and liver for practicing pathologists, hematopathologists and clinicians. The authors are from large academic centers, affiliated teaching hospitals and central referral clinics and are experienced in the diagnosis of hematopoietic disorders in the spleen and liver. The book consists of 21 chapters, with the first three chapters devoted to normal histologic features, conventional, cytogenetic and molecular studies necessary for the diagnosis of hematopoietic disorders in the spleen and liver. Chapters 4 to 17 cover the primary and secondary mature B- and T/NK cell lymphomas, Hodgkin lymphoma, B and T cell lymphoblastic leukemias, myeloid neoplasms, histiocytic and dendritic neoplasms, and post-transplant disorders including post transplant lymphoproliferative disorders. Chapters 19 to 21 encompass red blood cell disorders, other benign hematologic disorders and infectious/inflammatory disorders that could mimic hematopoietic neoplasms. These chapters are formatted on specific hematopoietic neoplasms to comprise epidemiology, etiology, pathogenesis, morphology, immunophenotyping, molecular genetics, prognosis and brief treatment guidelines. Diagnostic caveats are included in order to have a quick review of the key points in each chapter. Diagnostic Pathology of Hematopoietic Disorders of Spleen and Liver covers most, if not all of the benign and malignant hematopoietic disorders in the spleen and liver and serves as a practical and useful resource for general pathologists and hematopathologists.

Hematopoietic system. --- Hemopoietic system --- Hematopoiesis --- Hematopoietic System. --- Leukemia. --- Lymphoma. --- Neoplasms, Plasma Cell. --- Liver Diseases. --- Spleen. --- Hematopoietic Systems --- System, Hematopoietic --- Liver Dysfunction --- Disease, Liver --- Diseases, Liver --- Dysfunction, Liver --- Dysfunctions, Liver --- Liver Disease --- Liver Dysfunctions --- Plasma Cell Neoplasms --- Neoplasm, Plasma Cell --- Plasma Cell Neoplasm --- Germinoblastoma --- Lymphoma, Malignant --- Reticulolymphosarcoma --- Sarcoma, Germinoblastic --- Germinoblastic Sarcoma --- Germinoblastic Sarcomas --- Germinoblastomas --- Lymphomas --- Lymphomas, Malignant --- Malignant Lymphoma --- Malignant Lymphomas --- Reticulolymphosarcomas --- Sarcomas, Germinoblastic --- Lymphatic Diseases --- Hematologic Neoplasms --- Leucocythaemia --- Leucocythemia --- Leucocythaemias --- Leucocythemias --- Leukemias --- Myeloproliferative Disorders --- Pathology. --- Hematology. --- Oncology  . --- Oncology. --- Tumors --- Haematology --- Internal medicine --- Blood --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine --- Medicine, Preventive --- Malalties hematològiques --- Malalties del sistema limfàtic --- Melsa --- Fetge --- Diagnòstic. --- Oncologia --- Medicina --- Oncologia geriàtrica --- Oncologia pediàtrica --- Oncologia veterinària --- Càncer --- Infermeria oncològica --- Diagnosi --- Diagnòstic físic --- Examen mèdic (Diagnòstic) --- Exploració médica (Diagnòstic) --- Exploració clínica (Diagnòstic) --- Medicina clínica --- Cateterisme --- Cribratge --- Diagnòstic d'infermeria --- Diagnòstic diferencial --- Diagnòstic dual --- Diagnòstic molecular --- Diagnòstic prenatal --- Diagnòstic quirúrgic --- Diagnòstic per la imatge --- Electrodiagnòstic --- Entrevista clínica --- Examen físic --- Isòtops radioactius en diagnòstic mèdic --- Monitoratge de pacients --- Proves funcionals (Medicina) --- Patologia --- Pronòstic mèdic --- Símptomes --- Abdomen --- Aparell digestiu --- Tracte biliar --- Cèl·lules hepàtiques --- Bilis --- Cirurgia hepàtica --- Hepatologia --- Sistema limfàtic --- Elefantiasi --- Limfomes --- Malalties de la sang --- Malalties sanguínies --- Malalties --- Anèmia --- Eosinofília --- Mononucleosi --- Septicèmia --- Trastorns de les plaquetes sanguínies --- Hematologia