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Urogenital Neoplasms --- Immunotherapy. --- Neoadjuvant Therapy. --- Genitourinary organs --- therapy. --- Cancer --- Adjuvant treatment. --- Neoadjuvant Chemoradiation --- Neoadjuvant Chemoradiation Therapy --- Neoadjuvant Chemoradiation Treatment --- Neoadjuvant Chemoradiotherapy --- Neoadjuvant Chemotherapy --- Neoadjuvant Chemotherapy Treatment --- Neoadjuvant Radiation --- Neoadjuvant Radiation Therapy --- Neoadjuvant Radiation Treatment --- Neoadjuvant Radiotherapy --- Neoadjuvant Systemic Therapy --- Neoadjuvant Systemic Treatment --- Neoadjuvant Treatment --- Chemoradiation Therapy, Neoadjuvant --- Chemoradiation Treatment, Neoadjuvant --- Chemoradiation, Neoadjuvant --- Chemoradiotherapy, Neoadjuvant --- Chemotherapy Treatment, Neoadjuvant --- Chemotherapy, Neoadjuvant --- Neoadjuvant Chemoradiation Therapies --- Neoadjuvant Chemoradiation Treatments --- Neoadjuvant Chemoradiations --- Neoadjuvant Chemoradiotherapies --- Neoadjuvant Chemotherapies --- Neoadjuvant Chemotherapy Treatments --- Neoadjuvant Radiation Therapies --- Neoadjuvant Radiation Treatments --- Neoadjuvant Radiations --- Neoadjuvant Radiotherapies --- Neoadjuvant Systemic Therapies --- Neoadjuvant Systemic Treatments --- Neoadjuvant Therapies --- Neoadjuvant Treatments --- Radiation Therapy, Neoadjuvant --- Radiation Treatment, Neoadjuvant --- Radiation, Neoadjuvant --- Radiotherapy, Neoadjuvant --- Systemic Therapy, Neoadjuvant --- Systemic Treatment, Neoadjuvant --- Therapy, Neoadjuvant --- Therapy, Neoadjuvant Chemoradiation --- Therapy, Neoadjuvant Radiation --- Therapy, Neoadjuvant Systemic --- Treatment, Neoadjuvant --- Treatment, Neoadjuvant Chemoradiation --- Treatment, Neoadjuvant Chemotherapy --- Treatment, Neoadjuvant Radiation --- Treatment, Neoadjuvant Systemic --- Immunotherapies --- Combined Antibody Therapeutics --- Immunity, Active --- Immunologic Techniques

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Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.

Public health & preventive medicine --- gastric cancer --- gastrectomy --- complications --- outcome --- survival --- lymph node ratio --- neoadjuvant chemotherapy --- conversion surgery --- cancer dormancy --- nuclear receptor NR2F1 --- clinical pathways --- gastric surgery --- oncological gastrectomy --- quality of care --- outcomes --- standardization --- adjuvant therapy --- gastrointestinal tract --- genetic diagnosis --- radiosensitivity --- mortality --- failure to rescue --- immunotherapy --- genetics --- esophageal cancer --- multidisciplinary --- gastric/gastroesophageal cancer --- perioperative chemotherapy --- overall survival --- relapse-free survival --- skeletal muscle index --- esophagectomy --- nutritional status --- sarcopenia --- esophageal anastomosis --- minimally invasive surgery --- induction chemotherapy --- chemo-radiotherapy --- neoadjuvant treatment --- esophageal squamous cell carcinoma --- multimodal treatment --- neoadjuvant chemoradiotherapy --- definitive chemoradiotherapy --- Lauren histotype --- gastrointestinal stromal tumor --- neuroendocrine tumor --- MALT lymphoma --- mucosal resection --- submucosal dissection --- GIST --- stomach --- neoadjuvant therapy --- imatinib --- organ preservation --- squamous cell esophageal cancer --- gastro-esophageal reflux disease --- Barrett’s esophagus --- early adenocarcinoma of esophagus --- endoscopic submucosal dissection --- endoscopic mucosal resection --- n/a --- Barrett's esophagus

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Breast --- Cancer --- Surgery. --- Neoadjuvant Therapy. --- Breast Neoplasms. --- Sentinel Lymph Node. --- Axilla. --- Armpit --- Underarm --- Sentinal Node --- Lymph Node, Sentinel --- Lymph Nodes, Sentinel --- Node, Sentinal --- Nodes, Sentinal --- Sentinal Nodes --- Sentinel Lymph Nodes --- Lymphatic Metastasis --- Sentinel Lymph Node Biopsy --- Breast Carcinoma --- Cancer of the Breast --- Human Mammary Carcinoma --- Malignant Neoplasm of Breast --- Malignant Tumor of Breast --- Mammary Cancer --- Mammary Carcinoma, Human --- Mammary Neoplasm, Human --- Mammary Neoplasms, Human --- Neoplasms, Breast --- Tumors, Breast --- Breast Cancer --- Breast Tumors --- Cancer of Breast --- Breast Carcinomas --- Breast Malignant Neoplasm --- Breast Malignant Neoplasms --- Breast Malignant Tumor --- Breast Malignant Tumors --- Breast Neoplasm --- Breast Tumor --- Cancer, Breast --- Cancer, Mammary --- Cancers, Mammary --- Carcinoma, Breast --- Carcinoma, Human Mammary --- Carcinomas, Breast --- Carcinomas, Human Mammary --- Human Mammary Carcinomas --- Human Mammary Neoplasm --- Human Mammary Neoplasms --- Mammary Cancers --- Mammary Carcinomas, Human --- Neoplasm, Breast --- Neoplasm, Human Mammary --- Neoplasms, Human Mammary --- Tumor, Breast --- Breast Cancer Lymphedema --- Neoadjuvant Chemoradiation --- Neoadjuvant Chemoradiation Therapy --- Neoadjuvant Chemoradiation Treatment --- Neoadjuvant Chemoradiotherapy --- Neoadjuvant Chemotherapy --- Neoadjuvant Chemotherapy Treatment --- Neoadjuvant Radiation --- Neoadjuvant Radiation Therapy --- Neoadjuvant Radiation Treatment --- Neoadjuvant Radiotherapy --- Neoadjuvant Systemic Therapy --- Neoadjuvant Systemic Treatment --- Neoadjuvant Treatment --- Chemoradiation Therapy, Neoadjuvant --- Chemoradiation Treatment, Neoadjuvant --- Chemoradiation, Neoadjuvant --- Chemoradiotherapy, Neoadjuvant --- Chemotherapy Treatment, Neoadjuvant --- Chemotherapy, Neoadjuvant --- Neoadjuvant Chemoradiation Therapies --- Neoadjuvant Chemoradiation Treatments --- Neoadjuvant Chemoradiations --- Neoadjuvant Chemoradiotherapies --- Neoadjuvant Chemotherapies --- Neoadjuvant Chemotherapy Treatments --- Neoadjuvant Radiation Therapies --- Neoadjuvant Radiation Treatments --- Neoadjuvant Radiations --- Neoadjuvant Radiotherapies --- Neoadjuvant Systemic Therapies --- Neoadjuvant Systemic Treatments --- Neoadjuvant Therapies --- Neoadjuvant Treatments --- Radiation Therapy, Neoadjuvant --- Radiation Treatment, Neoadjuvant --- Radiation, Neoadjuvant --- Radiotherapy, Neoadjuvant --- Systemic Therapy, Neoadjuvant --- Systemic Treatment, Neoadjuvant --- Therapy, Neoadjuvant --- Therapy, Neoadjuvant Chemoradiation --- Therapy, Neoadjuvant Radiation --- Therapy, Neoadjuvant Systemic --- Treatment, Neoadjuvant --- Treatment, Neoadjuvant Chemoradiation --- Treatment, Neoadjuvant Chemotherapy --- Treatment, Neoadjuvant Radiation --- Treatment, Neoadjuvant Systemic

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Treatment Landscape of Targeted Therapies in Oncology: Challenges and Opportunities provides up-to-date knowledge on antitumor-targeted therapies and immunotherapy. The book's chapters are written by researchers dynamically working/focusing on cancer treatment. The content is designed to help those who are new to the field (beginners) and various specialized scientists and researchers involved in cancer research. For decades, the hallmark of cancer treatment has been conventional chemotherapy. But with the rapid increase in our understanding of the immune system, more and more small molecules, peptides, recombinant antibodies, vaccines and cellular therapeutic modalities are being applied to manipulate the immune response for cancer treatment.

Molecular Targeted Therapy. --- Immunotherapy. --- Neoadjuvant Therapy. --- Drug Therapy. --- Antineoplastic Agents. --- Neoplasms --- therapy. --- Anticancer Agents --- Antineoplastic Drugs --- Antineoplastics --- Antitumor Agents --- Antitumor Drugs --- Cancer Chemotherapy Agents --- Cancer Chemotherapy Drugs --- Chemotherapeutic Anticancer Agents --- Chemotherapeutic Anticancer Drug --- Anticancer Agent --- Antineoplastic --- Antineoplastic Agent --- Antineoplastic Drug --- Antitumor Agent --- Antitumor Drug --- Cancer Chemotherapy Agent --- Cancer Chemotherapy Drug --- Agent, Anticancer --- Agent, Antineoplastic --- Agent, Antitumor --- Agent, Cancer Chemotherapy --- Agents, Anticancer --- Agents, Antineoplastic --- Agents, Antitumor --- Agents, Cancer Chemotherapy --- Agents, Chemotherapeutic Anticancer --- Chemotherapy Agent, Cancer --- Chemotherapy Agents, Cancer --- Chemotherapy Drug, Cancer --- Chemotherapy Drugs, Cancer --- Drug, Antineoplastic --- Drug, Antitumor --- Drug, Cancer Chemotherapy --- Drug, Chemotherapeutic Anticancer --- Drugs, Antineoplastic --- Drugs, Antitumor --- Drugs, Cancer Chemotherapy --- Cytotoxins --- Interferon Inducers --- Anticarcinogenic Agents --- Therapy, Drug --- Chemotherapy --- Pharmacotherapy --- Chemotherapies --- Drug Therapies --- Pharmacotherapies --- Therapies, Drug --- Disease --- Pharmaceutical Preparations --- Pharmacologic Actions --- Neoadjuvant Chemoradiation --- Neoadjuvant Chemoradiation Therapy --- Neoadjuvant Chemoradiation Treatment --- Neoadjuvant Chemoradiotherapy --- Neoadjuvant Chemotherapy --- Neoadjuvant Chemotherapy Treatment --- Neoadjuvant Radiation --- Neoadjuvant Radiation Therapy --- Neoadjuvant Radiation Treatment --- Neoadjuvant Radiotherapy --- Neoadjuvant Systemic Therapy --- Neoadjuvant Systemic Treatment --- Neoadjuvant Treatment --- Chemoradiation Therapy, Neoadjuvant --- Chemoradiation Treatment, Neoadjuvant --- Chemoradiation, Neoadjuvant --- Chemoradiotherapy, Neoadjuvant --- Chemotherapy Treatment, Neoadjuvant --- Chemotherapy, Neoadjuvant --- Neoadjuvant Chemoradiation Therapies --- Neoadjuvant Chemoradiation Treatments --- Neoadjuvant Chemoradiations --- Neoadjuvant Chemoradiotherapies --- Neoadjuvant Chemotherapies --- Neoadjuvant Chemotherapy Treatments --- Neoadjuvant Radiation Therapies --- Neoadjuvant Radiation Treatments --- Neoadjuvant Radiations --- Neoadjuvant Radiotherapies --- Neoadjuvant Systemic Therapies --- Neoadjuvant Systemic Treatments --- Neoadjuvant Therapies --- Neoadjuvant Treatments --- Radiation Therapy, Neoadjuvant --- Radiation Treatment, Neoadjuvant --- Radiation, Neoadjuvant --- Radiotherapy, Neoadjuvant --- Systemic Therapy, Neoadjuvant --- Systemic Treatment, Neoadjuvant --- Therapy, Neoadjuvant --- Therapy, Neoadjuvant Chemoradiation --- Therapy, Neoadjuvant Radiation --- Therapy, Neoadjuvant Systemic --- Treatment, Neoadjuvant --- Treatment, Neoadjuvant Chemoradiation --- Treatment, Neoadjuvant Chemotherapy --- Treatment, Neoadjuvant Radiation --- Treatment, Neoadjuvant Systemic --- Immunotherapies --- Combined Antibody Therapeutics --- Immunity, Active --- Immunologic Techniques --- Targeted Molecular Therapy --- Molecular Targeted Therapies --- Molecular Therapy, Targeted --- Targeted Molecular Therapies --- Targeted Therapy, Molecular --- Therapy, Molecular Targeted --- Therapy, Targeted Molecular --- drug therapy --- therapeutic use --- Cancer --- Treatment --- Technological innovations. --- Immunotherapy --- Molecular Targeted Therapy --- therapy