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If you are engaged in the treatment of patients with MS (pwMS), this e-book’s aim is to offer novel insights to improve on an understanding of one of the major problems of pwMS: fatigue. Although there is increasing research into fatigue and its impact on MS, this collection of ten articles supports a better understanding of fatigue in MS patients. It explores pathophysiological concepts, provoking mechanisms, objective measurements, personality interactions, pharmacological and non-pharmacological interventions and summarizes clinical management. It is written by neurologists, psychologists, scientists and therapists and addresses this group of people, who deal with pwMS in private, clinical, rehabilitation or scientific settings. Its aim is to communicate high-quality information, knowledge and experience on MS to healthcare professionals, while providing global support for the international MS community.

Multiple sclerosis. --- MS (Disease) --- Sclerosis, Multiple --- Demyelination --- Myelin sheath --- Virus diseases --- Diseases --- Multiple Sclerosis --- cognitive fatigue --- motor fatigue --- Fatigue --- Depression --- Cognition --- Personality --- Rehabilitation --- gait analysis --- natalizumab

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We all agree that people with MS need to be cared in a profoundly personalized way. The care of the patient with MS is still based on the presence of relapses, so their successful diagnosis and treatment is fundamental and will condition the therapeutic strategies to follow with the patient. The treatment strategies are a highly controversial topic of debate that is increasingly supported by robust objective biological markers of response and that also increasingly take into account the dynamics and predictors of cognitive impairment along the disease course, which includes the adoption of new trends in the field of machine learning techniques. However, we all know that patient care goes beyond being treated with drugs and we cannot overlook reminding patients of the importance of their lifestyle behaviors that vary according to the MS phenotype, in order to improve their quality of life. Teleconsultation is a new care strategy proved to be feasible and well-received by patients with MS that will undoubtedly become reinforced because it will allow a closer follow-up of the patient without the need for displacement.

Public health & preventive medicine --- cognition --- cognitive impairment --- neuroimaging --- longitudinal --- predictors --- multiple sclerosis --- lifestyle behavior --- MS management --- MS phenotype --- quality of life --- natalizumab --- extended interval dose --- biomarker --- CD49d --- sVCAM-1 --- immunomonitoring --- personalized dose --- prognosis --- machine learning --- artificial intelligence --- relapse --- pseudo-relapses --- methylprednisolone --- treatment algorithm --- multiple sclerosis treatment --- escalating strategy --- he-DMT --- diseases modifying therapies --- early intense therapy --- teleconsultation --- internet --- feasibility --- digital health --- neuromyelitis optica spectrum disorder --- health-related quality of life --- mood --- n/a