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The book starts with the editors’ preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Research & information: general --- Biology, life sciences --- ascorbic acid --- deferoxamine --- N-acetylcysteine --- ischemia/reperfusion --- cardiac fibroblasts --- reactive oxygen species --- photobiomodulation --- reactive oxygen species (ROS) --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) --- cancer --- diabetes --- wound healing --- glucose --- pentose phosphate pathway --- NADPH --- redox balance --- glycogen --- glycolysis --- stress resistance --- insulin resistance --- immunomodulation --- inflammation --- olive tree --- oxidative stress --- secoirioids --- sirtuin 3 --- high fat diet --- sex differences --- mice --- metabolic stress --- antioxidants --- ADHD --- Nrf2 --- NRF2-KEAP1 --- ROS --- cancer metabolism --- antioxidant --- cancer therapy --- chemoresistance --- radioresistance --- sepsis --- MitoVitE --- mitochondria --- gene expression --- cytokines --- mRNA --- vitamin C --- folic acid --- one-carbon metabolism --- C2C12 cells --- metabolomics --- mass spectrometry --- type 2 diabetes --- dipeptidyl peptidase-4 inhibitors --- biomarkers --- ER stress --- Ezetimibe --- ischemia-reperfusion --- ionizing radiation --- liver --- hydroperoxide --- epigenetics --- miR7/MAFG/Nrf2 axe --- ascorbic acid --- deferoxamine --- N-acetylcysteine --- ischemia/reperfusion --- cardiac fibroblasts --- reactive oxygen species --- photobiomodulation --- reactive oxygen species (ROS) --- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-кB) --- cancer --- diabetes --- wound healing --- glucose --- pentose phosphate pathway --- NADPH --- redox balance --- glycogen --- glycolysis --- stress resistance --- insulin resistance --- immunomodulation --- inflammation --- olive tree --- oxidative stress --- secoirioids --- sirtuin 3 --- high fat diet --- sex differences --- mice --- metabolic stress --- antioxidants --- ADHD --- Nrf2 --- NRF2-KEAP1 --- ROS --- cancer metabolism --- antioxidant --- cancer therapy --- chemoresistance --- radioresistance --- sepsis --- MitoVitE --- mitochondria --- gene expression --- cytokines --- mRNA --- vitamin C --- folic acid --- one-carbon metabolism --- C2C12 cells --- metabolomics --- mass spectrometry --- type 2 diabetes --- dipeptidyl peptidase-4 inhibitors --- biomarkers --- ER stress --- Ezetimibe --- ischemia-reperfusion --- ionizing radiation --- liver --- hydroperoxide --- epigenetics --- miR7/MAFG/Nrf2 axe