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Nuclear factor kB : regulation and role in disease
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ISBN: 1402014341 Year: 2003 Publisher: Dordrecht : Kluwer academic,

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NF-kB in health and disease
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ISBN: 3642160166 3642160174 Year: 2011 Publisher: Berlin ; Heidelberg : Springer-Verlag,

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Abstract

This volume is focused on a transcription factor that started its life as a B cell-specific nuclear protein, but has matured to become one of the most extensively studied transcriptional regulators, found to control many pathophysiological processes: NF-kB. Articles in the volume, all of them written by the leading experts in the field, range from description of the NF-kB system and its basic components, its logic and its transcriptional regulatory functions to its participation in diverse processes, including inflammation, immunity, mucosal homeostasis and cancer. In addition to discussing the molecular biology and physiology of the NF-kB system, this volume also addresses the therapeutic targeting of NF-kB and its regulators. Thus, this volume is an important reading to both basic and translational scientists interested in different aspects of this highly versatile regulatory system.

NF-[kappa]B/Rel transcription factor family
Author:
ISBN: 1280800291 9786610800292 0387335730 0387335722 1441941401 Year: 2006 Publisher: Georgetown, TX : New York, N.Y. : Landes Bioscience/Eurekah.com ; Springer Science+Business Media,

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Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.


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The Multiple Therapeutic Targets of A20
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ISBN: 1493903985 1493903977 Year: 2014 Publisher: New York, NY : Springer New York : Imprint: Springer,

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This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.


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NF-κB-Related Genetic Diseases
Authors: --- --- --- --- --- et al.
ISBN: 3319258486 3319258508 Year: 2016 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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This book presents the diverse clinical, cellular and molecular manifestations of NF-KB-related genetic diseases. It shows that studying patient-related pathologies affecting the components of the NF-KB signaling pathway offers the opportunity to understand the various functions of NF-KB in humans, complementing studies performed with mouse models. In addition, people treating those patients acquire a deeper understanding of the molecular basis of the pathophysiological processes.

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