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Neovascularization --- Neovascularization. --- Neovascularization, Pathologic --- Neovascularization, Physiologic --- Néovascularisation --- Néovascularisation. --- Angiogenesis, Physiological --- Neovascularization, Physiological --- Physiologic Angiogenesis --- Physiologic Neovascularization --- Angiogenesis, Physiologic --- Physiological Angiogenesis --- Physiological Neovascularization --- Collateral Circulation --- Vascular Remodeling --- Angiogenesis, Pathological --- Neovascularization, Pathological --- Pathologic Angiogenesis --- Pathologic Neovascularization --- Angiogenesis, Pathologic --- Pathological Angiogenesis --- Pathological Neovascularization --- Blood-vessels --- Growth --- Biology --- Health Sciences --- Life Sciences --- General and Others --- Physiology --- Animal Physiology --- Cytology, Cell Biology --- Micro and Molecular Biology --- Angiogènesi --- Angiogènesi.

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Neovascularization --- Blood-vessels --- Cardiovascular pharmacology --- Tumor antigens --- Cardiovascular system --- Antigens --- Antigens. --- Cardiovascular pharmacology. --- Neovascularization. --- Tumor antigens. --- Growth --- Diseases --- Treatment --- Growth. --- Treatment. --- Néovascularisation --- Vaisseaux sanguins --- Pharmacologie cardiovasculaire --- Antigènes tumoraux --- Appareil cardiovasculaire --- Antigènes --- Croissance --- Maladies --- Traitement

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Currently, the cellular and molecular mechanisms governing the development and regulation of the vasculature are studied in­ tensely and the field is rapidly progressing. Recently, novel growth factors and growth factor receptors specifically acting on endothelial cells have been discovered. Through these factors, communication networks are established between endothelial cells, the basement membrane and the pericytes; this interplay is critical for the regulated development and maintenance of the vasculature. The awareness that deregulated angiogenesis con­ tributes to the progression of a number of diseases, such as cancer and inflammatory diseases, has clearly spurred the field to move forward. The focus of this book is on two important classes of endothelial cell specific growth factors, the vascular endothelial growth factor (VEGF) family, and the angiopoietins, and on their mechanisms of action. The reader will find up-to-date, fo­ cused reviews, which give the current picture, and indicate future directions. I would like to honor Dr. Judah Folkman for his important contributions to the establishment of the field and thank him for his support. Lena Claesson-Welsh List of Contents N. FERRARA Vascular Endothelial Growth Factor: Molecular and Biological Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . M. G. PERSICO, V. VINCENTI and T. DIPALMA Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PIGF) . . . . . . . . . . . . . . . . . 31 U. ERIKSSON and K. ALiTALO Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors. . . . . . . . . 41 M. SHIBUYA, N. ITo and L. CLAESSON-WELSH Structure and Function of Vascular Endothelial Growth Factor Receptor-I and -2 . . . . . . . . . . . . . . . . . . 59 J. TAIPALE, T. MAKINEN, E. ARIGHI, E.

Angiogenesis --- Croissance [Facteurs de ] --- Facteurs de croissance --- Factoren [Groei] --- Groeifactoren --- Growth factors --- Growth substances --- Neovascularisatie --- Neovascularization --- Néovascularisation --- Vascularisatie [Neo] --- Vascularisation [Néo] --- Endothelial Growth Factors --- Proteins --- Pathologic --- Endothelial Growth Factors. --- Proteins. --- Pathologic. --- Blood-vessels --- Growth --- Immunology. --- Cell biology. --- Cancer research. --- Molecular biology. --- Internal medicine. --- Cell Biology. --- Cancer Research. --- Molecular Medicine. --- Internal Medicine. --- Medicine, Internal --- Medicine --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Biomolecules --- Systems biology --- Cancer research --- Cell biology --- Cellular biology --- Biology --- Cells --- Immunobiology --- Life sciences --- Serology --- Vascular endothelium. --- Blood vessel endothelium --- Endothelium, Vascular --- Endothelium --- Endothelins

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In this reprint, we hope to review the basics and highlight the latest developments in AMD. This demonstrates the benefits of the international scientific community working on this disease, to limit its negative impacts, the most vital of which is the loss of visual function, leading to a loss of autonomy and a decrease in patients’ quality of life.

Medicine --- aflibercept monotherapy --- polypoidal choroidal vasculopathy --- neovascular age-related macular degeneration --- good baseline visual acuity --- ForeseeHome AMD Monitoring System® --- AREDS2-HOME study --- age-related macular degeneration --- exudation --- optical coherence tomography angiography --- anti-vascular endothelial growth factor --- brolucizumab --- epithelial tear --- optical coherence tomography --- Sorsby’s fundus dystrophy --- Sorsby --- hereditary retinal dystrophy --- choroidal neovascularisation --- macular neovascularization --- anti-VEGF treatment --- long-term FU --- treatment outcome --- emerging treatment --- neovascular age-related macular degeneration (nAMD) --- Vascular Endothelial Growth Factor (VEGF) --- cataract surgery --- clinical trials --- real-world evidence --- AMD --- oct-angiography --- fellow eye --- choriocapillaris --- quiescent macular neovascularization --- ranibizumab --- aflibercept --- anti-VEGF --- visual acuity --- reading acuity --- disease activity --- treatment change --- treat and extend --- switch therapy --- retina --- choroidal neovascularization --- angiogenesis --- meteorin --- therapeutic innovation --- prevention --- nutrients --- lifestyle --- treatment-naive --- anti–vascular endothelial growth factor --- cardiovascular risk factors --- arterial hypertension --- macula-off rhegmatogenous detachment --- superficial perifoveal capillary plexus --- retinal deep perifoveal capillary plexus --- identification --- risk --- Delphi --- STARS® --- food supplement --- bevacizumab --- meta-analysis --- meta-regression --- n/a --- age-related macular degeneration (AMD) --- comparative therapies --- effectiveness --- intravitreal anti-vascular endothelial growth factor --- treat-and-extend --- pro re nata regimen --- Sorsby's fundus dystrophy

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In this reprint, we hope to review the basics and highlight the latest developments in AMD. This demonstrates the benefits of the international scientific community working on this disease, to limit its negative impacts, the most vital of which is the loss of visual function, leading to a loss of autonomy and a decrease in patients’ quality of life.

Medicine --- aflibercept monotherapy --- polypoidal choroidal vasculopathy --- neovascular age-related macular degeneration --- good baseline visual acuity --- ForeseeHome AMD Monitoring System® --- AREDS2-HOME study --- age-related macular degeneration --- exudation --- optical coherence tomography angiography --- anti-vascular endothelial growth factor --- brolucizumab --- epithelial tear --- optical coherence tomography --- Sorsby's fundus dystrophy --- Sorsby --- hereditary retinal dystrophy --- choroidal neovascularisation --- macular neovascularization --- anti-VEGF treatment --- long-term FU --- treatment outcome --- emerging treatment --- neovascular age-related macular degeneration (nAMD) --- Vascular Endothelial Growth Factor (VEGF) --- cataract surgery --- clinical trials --- real-world evidence --- AMD --- oct-angiography --- fellow eye --- choriocapillaris --- quiescent macular neovascularization --- ranibizumab --- aflibercept --- anti-VEGF --- visual acuity --- reading acuity --- disease activity --- treatment change --- treat and extend --- switch therapy --- retina --- choroidal neovascularization --- angiogenesis --- meteorin --- therapeutic innovation --- prevention --- nutrients --- lifestyle --- treatment-naive --- cardiovascular risk factors --- arterial hypertension --- macula-off rhegmatogenous detachment --- superficial perifoveal capillary plexus --- retinal deep perifoveal capillary plexus --- identification --- risk --- Delphi --- STARS® --- food supplement --- bevacizumab --- meta-analysis --- meta-regression --- age-related macular degeneration (AMD) --- comparative therapies --- effectiveness --- intravitreal anti-vascular endothelial growth factor --- treat-and-extend --- pro re nata regimen