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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
immunometabolism --- metabolic reprogramming --- immune cell regulation --- cell fate decisions --- T cells --- myeloid cells --- innate lymphoid cells
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Medicine --- Immunology --- immunometabolism --- metabolic reprogramming --- immune cell regulation --- cell fate decisions --- T cells --- myeloid cells --- innate lymphoid cells --- immunometabolism --- metabolic reprogramming --- immune cell regulation --- cell fate decisions --- T cells --- myeloid cells --- innate lymphoid cells
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
Medicine --- Immunology --- immunometabolism --- metabolic reprogramming --- immune cell regulation --- cell fate decisions --- T cells --- myeloid cells --- innate lymphoid cells
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Macrophages are tissue resident phagocytes that have important roles in development and immunity. The observation that cancers become infiltrated by large numbers of macrophages was first made by Virchow in 1863, clinical and experimental studies suggest tumor-associated macrophages (TAM) are critical to promote carcinogenesis and tumor-progression, however to this day it still isn’t clear what regulates the recruitment of macrophages in tumors and what drives their pro-tumor functions. This volume will provide an overview of current research on the form and function of TAM, highlighting both the mechanistic roles they play in carcinogenesis and tumor progression as well as the molecular mechanisms that control their phenotype and function, and the final chapter addresses the issue of TAM as a potential target in cancer therapy.
Cancer -- Research. --- Macrophages. --- Tumors. --- Macrophages --- Tumors --- Immunology --- Cancer --- Disease Attributes --- Mononuclear Phagocyte System --- Phagocytes --- Connective Tissue Cells --- Myeloid Cells --- Diseases --- Cells --- Immune System --- Pathologic Processes --- Anatomy --- Pathological Conditions, Signs and Symptoms --- Hemic and Immune Systems --- Neoplasms --- Disease Progression --- Biology --- Medicine --- Health & Biological Sciences --- Oncology --- Microbiology & Immunology --- Growth --- Immunological aspects --- Tumours --- Histiocytes --- Mononuclear phagocytes --- Medicine. --- Cancer research. --- Pharmacology. --- Biomedicine. --- Cancer Research. --- Pharmacology/Toxicology. --- Pathology --- Cysts (Pathology) --- Antigen presenting cells --- Connective tissue cells --- Killer cells --- Reticulo-endothelial system
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Methods in Bone Biology is unique in being devoted to describing the methodology used by bone researchers. This book describes in detail the techniques of cell and organ culture used in the study of bone and bone cell function and the techniques used to monitor the skeleton and skeletal remodelling both in clinical and experimental settings.
Physiology: movement organs, voice and skin --- Bone and Bones --- Osteoblasts --- Osteoclasts --- Bone Diseases --- Cytological Techniques. --- Bones --- Os --- cytology. --- physiology. --- pathology. --- Physiology. --- Molecular aspects. --- Physiologie --- Bones -- Molecular aspects. --- Bones -- Physiology. --- Electronic books. -- local. --- Cytological Techniques --- Musculoskeletal Diseases --- Skeleton --- Macrophages --- Connective Tissue --- Connective Tissue Cells --- Clinical Laboratory Techniques --- Diseases --- Myeloid Cells --- Musculoskeletal System --- Cells --- Tissues --- Investigative Techniques --- Anatomy --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Physiology --- Human Anatomy & Physiology --- Health & Biological Sciences --- Life sciences. --- Pathology. --- Animal physiology. --- Life Sciences. --- Animal Physiology. --- Disease (Pathology) --- Medical sciences --- Medicine --- Medicine, Preventive --- Animal physiology --- Animals --- Biology --- Bone cells. --- Diseases. --- Bone corpuscles --- Osseous cells --- Cartilage cells
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This second edition of this book expands further on the first edition, which explored the relationship between the human immune system and the skeletal structure. In the past, scientists involved in immune and bone-cell investigations have rarely interacted in a significant way, as these disciplines have developed independently and, for the most part, remain separate. This book brings together ideas of international scientists from both fields in pursuit of new collaborations. This may facilitate greater understanding of the relationships between these fields.
Immunology. --- Musculoskeletal system. --- Natural immunity. --- Immunology --- Musculoskeletal system --- Musculoskeletal Diseases --- Connective Tissue --- Macrophages --- Hematologic Diseases --- Skeleton --- Connective Tissue Cells --- Myeloid Cells --- Musculoskeletal System --- Diseases --- Hemic and Lymphatic Diseases --- Tissues --- Cells --- Anatomy --- Osteoclasts --- Bone and Bones --- Bone Marrow Diseases --- Bone Diseases --- Human Anatomy & Physiology --- Biology --- Health & Biological Sciences --- Microbiology & Immunology --- Physiology --- Locomotor system --- Musculo-skeletal system --- Skeletomuscular system --- Immunobiology --- Medicine. --- Human physiology. --- Biomedicine. --- Biomedicine general. --- Human Physiology. --- Life sciences --- Serology --- Human biology --- Medical sciences --- Human body --- Clinical sciences --- Medical profession --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce
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It has only recently been appreciated that the immune and skeletal systems have major interactions. It is now well documented that osteoclasts, which are important cellular mediators of skeletal homeostasis, are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines that were first shown to regulate immune cell function have also been demonstrated to regulate bone cells and influence skeletal health. Conversely, products of bone cells appear critical for the engraftment of marrow in bone, the normal development of the hematopoietic and immune systems and provide niche for long-term memory B and T cells. In the past scientists involved in immune and bone cell investigations have rarely interacted in a significant way as these disciplines have developed independently and, for the most part, remain separate. The conference will bring together leading international scientists from both fields to interact so that new collaboration can develop and more rapid progress in understanding the relationships between these fields can be achieved. Short talks will be selected from abstracts from the international community. This conference will have a format to provide an environment of maximum interaction and interchange through lectures, posters, and open discussion.
Allergy and Immunology -- Congresses. --- Bone and Bones -- immunology -- Congresses. --- Immunology. --- Musculoskeletal Diseases -- immunology -- Congresses. --- Musculoskeletal System -- immunology -- Congresses. --- Musculoskeletal system. --- Immunology --- Musculoskeletal system --- Hematologic Diseases --- Skeleton --- Musculoskeletal Diseases --- Connective Tissue --- Publication Formats --- Connective Tissue Cells --- Macrophages --- Osteoclasts --- Bone Marrow Diseases --- Osteoblasts --- Congresses --- Bone and Bones --- Bone Diseases --- Myeloid Cells --- Cells --- Diseases --- Hemic and Lymphatic Diseases --- Tissues --- Musculoskeletal System --- Publication Characteristics --- Anatomy --- Biology --- Medicine --- Microbiology & Immunology --- Medical Research --- Health & Biological Sciences --- Locomotor system --- Musculo-skeletal system --- Skeletomuscular system --- Immunobiology --- Medicine. --- Pharmacology. --- Biotechnology. --- Infectious diseases. --- Pathology. --- Microbiology. --- Biomedicine. --- Infectious Diseases. --- Pharmacology/Toxicology. --- Life sciences --- Serology --- Microbial biology --- Microorganisms --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive --- Chemical engineering --- Genetic engineering --- Drug effects --- Medical pharmacology --- Chemicals --- Chemotherapy --- Drugs --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Physiological effect --- Emerging infectious diseases. --- Toxicology. --- Pharmacology --- Poisoning --- Poisons --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Toxicology
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In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy.
Medicine --- hypoxia --- macrophages --- colon cancer --- tumor microenvironment --- immune cell infiltration --- prognosis --- feline mammary carcinoma --- PD-1 --- PD-L1 --- CTLA-4 --- TNF-α --- biomarkers --- immunotherapy --- cancer --- histone modification --- inhibitor --- KDM5B --- molecular docking --- repurposing --- cancer acidity --- hyperosmolarity --- cross-presentation --- tumour microenvironment --- syngeneic model --- prostate cancer --- radiotherapy --- preclinical modelling --- myeloid-derived suppressor cells --- biomarker --- stroma --- cancer-associated fibroblast (CAF) --- extracellular matrix (ECM) --- cytokine/chemokine --- growth factors --- pro- and anti-tumor immune cells --- immunomodulatory roles --- radiotherapy dose fractionation --- radioresistance --- radiosensitivity --- breast cancer --- S100A10 (p11) --- tumor growth --- tumor progression --- metastasis --- carcinoma --- mammary gland --- triple negative --- pre-metastatic niche --- pro-inflammatory cytokines --- clinical trials --- evolutionary therapy --- darwinian evolution --- cancer cells subpopulations --- diclofenac --- koningic acid --- spheroid --- 3D co-culture --- microenvironment --- resistance --- myeloid cells --- cancer development --- molecular subtypes of pancreatic cancer --- chemotherapy response --- pancreatic stellate cells --- regulatory T cells --- tumor-associated macrophages --- myeloid derived suppressor cells --- glioblastoma (GB) --- Hypoxia Inducible Factor (HIF) --- glioma stem cells (GSC) --- oxidative stress --- reactive oxygen species --- plasmin --- plasminogen --- S100A10 --- uPA --- uPAR --- PAI-1 --- PAI-2 --- cancer stem cells --- cancer recurrence --- therapeutic resistance --- signaling pathways --- targeted therapy --- head and neck cancer --- lung cancer --- bladder cancer --- hypoxia --- macrophages --- colon cancer --- tumor microenvironment --- immune cell infiltration --- prognosis --- feline mammary carcinoma --- PD-1 --- PD-L1 --- CTLA-4 --- TNF-α --- biomarkers --- immunotherapy --- cancer --- histone modification --- inhibitor --- KDM5B --- molecular docking --- repurposing --- cancer acidity --- hyperosmolarity --- cross-presentation --- tumour microenvironment --- syngeneic model --- prostate cancer --- radiotherapy --- preclinical modelling --- myeloid-derived suppressor cells --- biomarker --- stroma --- cancer-associated fibroblast (CAF) --- extracellular matrix (ECM) --- cytokine/chemokine --- growth factors --- pro- and anti-tumor immune cells --- immunomodulatory roles --- radiotherapy dose fractionation --- radioresistance --- radiosensitivity --- breast cancer --- S100A10 (p11) --- tumor growth --- tumor progression --- metastasis --- carcinoma --- mammary gland --- triple negative --- pre-metastatic niche --- pro-inflammatory cytokines --- clinical trials --- evolutionary therapy --- darwinian evolution --- cancer cells subpopulations --- diclofenac --- koningic acid --- spheroid --- 3D co-culture --- microenvironment --- resistance --- myeloid cells --- cancer development --- molecular subtypes of pancreatic cancer --- chemotherapy response --- pancreatic stellate cells --- regulatory T cells --- tumor-associated macrophages --- myeloid derived suppressor cells --- glioblastoma (GB) --- Hypoxia Inducible Factor (HIF) --- glioma stem cells (GSC) --- oxidative stress --- reactive oxygen species --- plasmin --- plasminogen --- S100A10 --- uPA --- uPAR --- PAI-1 --- PAI-2 --- cancer stem cells --- cancer recurrence --- therapeutic resistance --- signaling pathways --- targeted therapy --- head and neck cancer --- lung cancer --- bladder cancer
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In this book, we present a compilation of original research articles as well as review articles that are focused on improving our understanding of the molecular and cellular mechanisms by which cancer cells adapt to their microenvironment. These include the interplay between cancer cells and the surrounding microenvironmental cells (e.g., macrophages, tumor-infiltrating lymphocytes and myeloid cells) and microenvironmental environments (e.g., oxidative stress, pH, hypoxia) and the implications of this dynamic interaction to tumor radioresistance, chemoresistance, invasion and metastasis. Finally, the importance and relevance of these findings are translated to cancer therapy.
Medicine --- hypoxia --- macrophages --- colon cancer --- tumor microenvironment --- immune cell infiltration --- prognosis --- feline mammary carcinoma --- PD-1 --- PD-L1 --- CTLA-4 --- TNF-α --- biomarkers --- immunotherapy --- cancer --- histone modification --- inhibitor --- KDM5B --- molecular docking --- repurposing --- cancer acidity --- hyperosmolarity --- cross-presentation --- tumour microenvironment --- syngeneic model --- prostate cancer --- radiotherapy --- preclinical modelling --- myeloid-derived suppressor cells --- biomarker --- stroma --- cancer-associated fibroblast (CAF) --- extracellular matrix (ECM) --- cytokine/chemokine --- growth factors --- pro- and anti-tumor immune cells --- immunomodulatory roles --- radiotherapy dose fractionation --- radioresistance --- radiosensitivity --- breast cancer --- S100A10 (p11) --- tumor growth --- tumor progression --- metastasis --- carcinoma --- mammary gland --- triple negative --- pre-metastatic niche --- pro-inflammatory cytokines --- clinical trials --- evolutionary therapy --- darwinian evolution --- cancer cells subpopulations --- diclofenac --- koningic acid --- spheroid --- 3D co-culture --- microenvironment --- resistance --- myeloid cells --- cancer development --- molecular subtypes of pancreatic cancer --- chemotherapy response --- pancreatic stellate cells --- regulatory T cells --- tumor-associated macrophages --- myeloid derived suppressor cells --- glioblastoma (GB) --- Hypoxia Inducible Factor (HIF) --- glioma stem cells (GSC) --- oxidative stress --- reactive oxygen species --- plasmin --- plasminogen --- S100A10 --- uPA --- uPAR --- PAI-1 --- PAI-2 --- cancer stem cells --- cancer recurrence --- therapeutic resistance --- signaling pathways --- targeted therapy --- head and neck cancer --- lung cancer --- bladder cancer
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