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Mycoplasma pneumoniae (Mp) is a major human pathogen that causes both upper and lower respiratory infections, and is one of the leading causes of community acquired pneumonia (CAP), accounting for 11–15% of CAP throughout the world. Additionally it is known to induce an inflammatory process which depends on several mechanisms such as virulence of Mp (lipoproteins, community acquired respiratory distress syndrome (CARDS) toxin, oxidative products) and host defenses (cellular immunity and humoral immunity). Although it is a common pathogen, the pathogenesis for Mp infections is not yet fully understood. From the clinical point of view, since the pioneer studies in the 1960s and 1970s on the clinical presentation of Mp associated disease, the diagnostics approaches have changed dramatically leading to a better understanding of the clinical presentation and new issues have emerged - such as antibiotics resistance. The purpose of this Frontiers ebook is to thoroughly review and discuss the clinical presentation in view of the improved diagnostics, microbiological and immunological analysis of Mp infections, with focus on the history of Mp, clinical features of disease, bacterial structure of Mp and mechanism of gliding, clinical and laboratory diagnostics, the role of lipoproteins and Toll-like receptor, CARDS toxin, subtyping of Mp isolates and genome analysis, macrolide resistance and treatment.

pathogenesis --- epidemiology --- treatment --- clinical presentation antimicrobial resistance --- Mycoplasma pneumoniae --- outcome

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Mycoplasma pneumoniae --- Pneumonia, Mycoplasma --- genetics --- microbiology --- epidemiology --- isolation & purification

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Respiratory Tract Infections --- Bacterial Infections --- Virus Diseases --- Mycoplasma pneumoniae --- Pneumonia, Mycoplasma --- Family Practice --- microbiology --- diagnosis --- diagnosis --- isolation & purification --- diagnosis

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There are 12 papers published with 8 research articles, 3 review articles and 1 perspective. The topics cover: Biomedical microfluidics Lab-on-a-chip Miniaturized systems for chemistry and life science (MicroTAS) Biosensor development and characteristics Imaging and other detection technologies Imaging and signal processing Point-of-care testing microdevices Food and water quality testing and control We hope this collection could promote the development of microfluidics and point-of-care testing (POCT) devices for biosensing.

Technology: general issues --- amine functionalization --- graphene oxide --- immunosensor --- electrochemistry --- ferritin --- microfluidics --- synthesis --- nanoparticles --- microparticles --- integrated systems --- modularisation --- HFF-QCM (high fundamental frequency quartz crystal microbalance) --- mass transport --- flow cell --- biosensor --- food safety --- PoC (point of care) --- MQCM (monolithic quartz crystal microbalance) --- wearable biosensors --- biomedical microfluidics --- healthcare monitoring --- sports analytics --- microfluidic adsorption-based sensor --- stochastic model --- adsorption --- mass transfer --- ultimate noise performance --- detection limit --- quantification limit --- fluorescence-linked immunosorbent assay --- lab-on-a-disk --- vascular endothelial growth factor --- 3D microstructure --- high-frequency dielectrophoresis --- glioblastoma cells --- single cell manipulation --- microfluidic point-of-care device --- cancer stem cells --- microstructure topography --- PC12 cells --- neural differentiation --- capillary pressure control valve (CPCV) --- passive valve --- two-phase biocatalysis --- microfluidic droplets --- enzyme --- dental practice --- point-of-care diagnostics --- treatment monitoring --- oral health --- periodontitis --- caries --- saliva diagnostics --- Mycoplasma pneumoniae --- macrolides --- resistance mutations --- microfluidic --- 3D-printed --- sample-to-answer --- qPCR

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There are 12 papers published with 8 research articles, 3 review articles and 1 perspective. The topics cover: Biomedical microfluidics Lab-on-a-chip Miniaturized systems for chemistry and life science (MicroTAS) Biosensor development and characteristics Imaging and other detection technologies Imaging and signal processing Point-of-care testing microdevices Food and water quality testing and control We hope this collection could promote the development of microfluidics and point-of-care testing (POCT) devices for biosensing.

Technology: general issues --- amine functionalization --- graphene oxide --- immunosensor --- electrochemistry --- ferritin --- microfluidics --- synthesis --- nanoparticles --- microparticles --- integrated systems --- modularisation --- HFF-QCM (high fundamental frequency quartz crystal microbalance) --- mass transport --- flow cell --- biosensor --- food safety --- PoC (point of care) --- MQCM (monolithic quartz crystal microbalance) --- wearable biosensors --- biomedical microfluidics --- healthcare monitoring --- sports analytics --- microfluidic adsorption-based sensor --- stochastic model --- adsorption --- mass transfer --- ultimate noise performance --- detection limit --- quantification limit --- fluorescence-linked immunosorbent assay --- lab-on-a-disk --- vascular endothelial growth factor --- 3D microstructure --- high-frequency dielectrophoresis --- glioblastoma cells --- single cell manipulation --- microfluidic point-of-care device --- cancer stem cells --- microstructure topography --- PC12 cells --- neural differentiation --- capillary pressure control valve (CPCV) --- passive valve --- two-phase biocatalysis --- microfluidic droplets --- enzyme --- dental practice --- point-of-care diagnostics --- treatment monitoring --- oral health --- periodontitis --- caries --- saliva diagnostics --- Mycoplasma pneumoniae --- macrolides --- resistance mutations --- microfluidic --- 3D-printed --- sample-to-answer --- qPCR --- amine functionalization --- graphene oxide --- immunosensor --- electrochemistry --- ferritin --- microfluidics --- synthesis --- nanoparticles --- microparticles --- integrated systems --- modularisation --- HFF-QCM (high fundamental frequency quartz crystal microbalance) --- mass transport --- flow cell --- biosensor --- food safety --- PoC (point of care) --- MQCM (monolithic quartz crystal microbalance) --- wearable biosensors --- biomedical microfluidics --- healthcare monitoring --- sports analytics --- microfluidic adsorption-based sensor --- stochastic model --- adsorption --- mass transfer --- ultimate noise performance --- detection limit --- quantification limit --- fluorescence-linked immunosorbent assay --- lab-on-a-disk --- vascular endothelial growth factor --- 3D microstructure --- high-frequency dielectrophoresis --- glioblastoma cells --- single cell manipulation --- microfluidic point-of-care device --- cancer stem cells --- microstructure topography --- PC12 cells --- neural differentiation --- capillary pressure control valve (CPCV) --- passive valve --- two-phase biocatalysis --- microfluidic droplets --- enzyme --- dental practice --- point-of-care diagnostics --- treatment monitoring --- oral health --- periodontitis --- caries --- saliva diagnostics --- Mycoplasma pneumoniae --- macrolides --- resistance mutations --- microfluidic --- 3D-printed --- sample-to-answer --- qPCR