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Muscle: Fundamental Biology and Mechanisms of Disease will be the first reference covering cardiac, skeletal, and smooth muscle in fundamental, basic science, translational biology, disease mechanism, and therapeutics. Currently there are no publications covering the science behind the medicine, as the majority of books are 90% clinical and 10% science. Muscle: Fundamental Biology and Mechanisms of Disease will discuss myocyte biology, also known as muscle cell biology, providing information about the science behind clinical work and therapeutics with a 90% science and 10% clinical focus. A needed resource for researchers, clinical professionals, postdocs, and graduate students, this publication will further discuss basic biology development and physiology, how processes go awry in disease states, and how the defective pathways are targeted for therapy. This book will assist both the new and experienced clinician's and researcher's need for science translation of background research into clinical applications, bridging the gap between research and clinical knowledge.

Medicine. --- Muscles -- Diseases. --- Muscles -- Physiology. --- Muscles. --- Muscles --- Musculoskeletal System --- Anatomy --- Human Anatomy & Physiology --- Health & Biological Sciences --- Physiology --- Diseases --- Physiology. --- Muscle --- Musculature --- Myodynamics --- Myology --- Musculoskeletal system --- Tissues

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Muscular dystrophy --- Muscles --- Genetic aspects --- Congresses --- Animal models --- Diseases --- 591.2 --- 616.74 --- 619 --- -Muscles --- -Muscular dystrophy --- -Muscular dystrophies --- Dystrophy --- Genetic disorders --- Neuromuscular diseases --- Muscle --- Musculature --- Myodynamics --- Myology --- Musculoskeletal system --- Tissues --- Diseases of (undomesticated) animals. Animal pathology --- Clinical myology. Muscular system. Skeletal musculature --- Diseases of domesticated animals. Veterinary science --- -Animal models --- -Congresses --- -Genetic aspects --- Congresses. --- -Diseases of (undomesticated) animals. Animal pathology --- 619 Diseases of domesticated animals. Veterinary science --- 616.74 Clinical myology. Muscular system. Skeletal musculature --- 591.2 Diseases of (undomesticated) animals. Animal pathology --- -619 Diseases of domesticated animals. Veterinary science --- Muscular dystrophies --- Diseases&delete& --- Animal models&delete& --- Genetic aspects&delete& --- 619 Ziektes van gedomesticeerde dieren. Diergeneeskunde --- Ziektes van gedomesticeerde dieren. Diergeneeskunde --- Muscular dystrophy - Genetic aspects - Congresses --- Muscular dystrophy - Animal models - Congresses --- Muscles - Diseases - Genetic aspects - Congresses --- Muscles - Diseases - Animal models - Congresses

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Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.

Biomedicine. --- Biomedicine general. --- Human Physiology. --- Medicine. --- Human physiology. --- Médecine --- Physiologie humaine --- Muscles -- Diseases. --- Muscles --- Muscular Diseases --- Sarcomeres --- Muscle, Skeletal --- Myofibrils --- Organelles --- Neuromuscular Diseases --- Musculoskeletal Diseases --- Muscle, Striated --- Musculoskeletal System --- Muscle Fibers, Skeletal --- Diseases --- Cytoplasmic Structures --- Myocytes, Cardiac --- Nervous System Diseases --- Anatomy --- Muscle Cells --- Cytoplasm --- Tissues --- Cells --- Intracellular Space --- Cellular Structures --- Musculoskeletal System Diseases --- Medicine --- Health & Biological Sciences --- Diseases. --- Myopathy --- Human biology --- Medical sciences --- Physiology --- Human body --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce

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Action potentials (Electrophysiology) --- Nervous system --- Muscles --- Diseases --- Neural conduction. --- Synaptic Transmission. --- Neuro-muscular junction --- Nervous System Malformations. --- Nervous System Physiological Phenomena. --- Abnormalities, Congenital, Nervous System --- Abnormalities, Nervous System --- Anomalies, Nervous System --- Congenital Abnormalities, Nervous System --- Congenital Anomalies, Nervous System --- Congenital Malformations, Nervous System --- Cranioschisis --- Malformations, Nervous System, Congenital --- Nervous System Anomalies --- Nervous System Congenital Abnormalities --- Nervous System Congenital Malformations --- Nervous System Malformations, Congenital --- Nervous System Abnormalities --- Abnormality, Nervous System --- Anomaly, Nervous System --- Cranioschises --- Malformation, Nervous System --- Malformations, Nervous System --- Nervous System Abnormality --- Nervous System Anomaly --- Nervous System Malformation --- Nervous System --- Nervous System Physiological Concepts --- Nervous System Physiological Phenomenon --- Nervous System Physiological Process --- Physiology, Nervous System --- Nervous System Physiologic Processes --- Nervous System Physiological Processes --- Nervous System Physiology --- System Physiology, Nervous --- Transmission, Neural --- Transmission, Synaptic --- Neural Transmission --- Neurotransmission --- Neural Conduction --- Synapses --- Nerve Conduction --- Conduction, Nerve --- Conduction, Neural --- Conductions, Nerve --- Conductions, Neural --- Nerve Conductions --- Neural Conductions --- Action Potentials --- Neurons --- Muscle Tissue --- Muscle --- Muscle Tissues --- Tissue, Muscle --- Tissues, Muscle --- Nervous Systems --- System, Nervous --- Systems, Nervous --- Diseases. --- Physiology. --- Abnormalities. --- abnormalities --- physiology --- Neural Conduction. --- Nervous System Malformations --- Nervous System Physiological Phenomena --- Synaptic Transmission --- Medical neurology --- Nerves --- Neurologic disorders --- Neurological disorders --- Neuropathology --- Neurology --- Myopathy --- Electrophysiology --- Abnormalities --- Physiology --- Nervous system - Diseases --- Muscles - Diseases