Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included.   The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered.  This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.

Amyloidosis. --- Multiprotein Complexes --- Proteostasis Deficiencies --- Proteins --- Amino Acids, Peptides, and Proteins --- Macromolecular Substances --- Metabolic Diseases --- Nutritional and Metabolic Diseases --- Chemicals and Drugs --- Diseases --- Amyloidosis --- Amyloid --- Medicine --- Health & Biological Sciences --- Pathology --- Metabolism --- Disorders. --- Protein metabolism disorders --- Amyloid degeneration --- Medicine. --- Internal medicine. --- Nephrology. --- Pathology. --- Medicine & Public Health. --- Internal Medicine. --- Lymphoproliferative disorders --- Disorders --- Medicine, Internal --- Internal medicine --- Kidneys --- Disease (Pathology) --- Medical sciences --- Medicine, Preventive

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The targeted addition of ubiquitin to proteins is now known to regulate many cellular events, with the enzymes involved in protein ubiquitination linked to a variety of clinical problems, such as cancer, heart disease, and immune dysfunction. In Ubiquitin-Proteasome Protocols, hands-on leaders in the field, many of whom originally developed the methods they describe, detail cutting-edge techniques for studying ubiquitin-dependent protein degradation via the proteasome. The topics covered range broadly from basic biochemistry to cellular assays to discovery techniques using mass spectrometric analysis. These biochemical and cellular methods are necessary to explore the ubiquitin-proteasome system and ubiquitin-proteasome- dependent functions. The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Electronic books. -- local. --- Proteolytic enzymes -- Laboratory manuals. --- Ubiquitin -- Laboratory manuals. --- Multienzyme Complexes --- Ubiquitin --- Cysteine Endopeptidases --- Multiprotein Complexes --- Enzymes --- Cysteine Proteases --- Ubiquitins --- Endopeptidases --- Peptide Hydrolases --- Macromolecular Substances --- Proteins --- Enzymes and Coenzymes --- Hydrolases --- Chemicals and Drugs --- Amino Acids, Peptides, and Proteins --- Proteolytic enzymes --- Cysteine Endopeptidases. --- Multienzyme Complexes. --- Ubiquitine --- Enzymes protéolytiques --- metabolism. --- Laboratory manuals --- Manuels de laboratoire --- EPUB-LIV-FT SPRINGER-B LIVBIOLO --- Peptide hydrolases --- Proteases --- High mobility protein 20 --- HMP-20 --- Biochemistry. --- Biochemistry, general. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Composition --- Laboratory manuals.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The ubiquitin system plays an essential role in numerous cellular processes by controlling protein stability and function. An understanding of the mechanisms governing these processes is likely to allow the identification of novel targets for pharmacological intervention. This work covers the developments in this field.

Ubiquitin. --- Ubiquitin --- Proteasome Endopeptidase Complex --- Ubiquitins --- Peptide Hydrolases --- Multienzyme Complexes --- Proteins --- Enzymes --- Hydrolases --- Multiprotein Complexes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Macromolecular Substances --- Enzymes and Coenzymes --- Animal Biochemistry --- Pathology --- Medicine --- Human Anatomy & Physiology --- Health & Biological Sciences --- High mobility protein 20 --- HMP-20 --- Medicine. --- Medical biochemistry. --- Medicine & Public Health. --- Medical Biochemistry. --- Biomedicine general. --- Medicine/Public Health, general. --- Biochemistry. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Composition --- Health Workforce --- Biomedicine, general. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Clinical biochemistry.

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

X-Ray Diffraction --- Macromolecular Substances --- Chemicals and Drugs --- Crystallography --- Chemistry Techniques, Analytical --- Investigative Techniques --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Crystallography, X-Ray --- Multiprotein Complexes --- Chemical & Materials Engineering --- Engineering & Applied Sciences --- Materials Science --- Macromolecules --- Physics. --- Computer simulation. --- Proteins. --- Bioinformatics. --- Crystallography. --- Protein-Ligand Interactions. --- Protein Structure. --- Simulation and Modeling. --- RNA-ligand interactions. --- Biochemistry. --- Crystallography and Scattering Methods. --- Bio-informatics --- Biological informatics --- Biology --- Information science --- Computational biology --- Systems biology --- Computer modeling --- Computer models --- Modeling, Computer --- Models, Computer --- Simulation, Computer --- Electromechanical analogies --- Mathematical models --- Simulation methods --- Model-integrated computing --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Leptology --- Physical sciences --- Mineralogy --- Data processing --- Composition --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.

Inflammation -- Immunological aspects. --- Proteasome Endopeptidase Complex. --- Proteins -- metabolism. --- Inflammation --- Biological Factors --- Multiprotein Complexes --- Chemicals and Drugs --- Macromolecular Substances --- Inflammasomes --- Inflammation Mediators --- Biology --- Medicine --- Health & Biological Sciences --- Microbiology & Immunology --- Pathology --- Pathophysiology --- Immunological aspects --- Molecular aspects --- Mediators --- Inflammation. --- Inflammatory process --- Medicine. --- Immunology. --- Infectious diseases. --- Enzymology. --- Cytokines. --- Growth factors. --- Cell biology. --- Biomedicine. --- Infectious Diseases. --- Cell Biology. --- Cytokines and Growth Factors. --- Anti-inflammatory agents --- Emerging infectious diseases. --- Cytology. --- Enzymes. --- Biocatalysts --- Ferments --- Soluble ferments --- Catalysts --- Proteins --- Enzymology --- Cellular immunity --- Immune response --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases --- Immunobiology --- Life sciences --- Serology --- Regulation --- Biochemistry --- Enzymes --- Cell growth factors --- Cellular growth factors --- Growth peptides --- Growth promoting substances --- Growth substances --- Peptide growth factors --- Peptide regulatory factors --- Polypeptide growth factors --- Cytokines --- Peptides