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Multiple drug resistance among bacteria has become a global issue with a considerable impact on the mortality associated with infectious diseases. This book is a detailed compilation of available knowledge on the surveillance and mechanisms of antibiotic resistance in various countries throughout the world. Readers will be updated on current information on the understanding of mechanisms involved in drug resistance and the geographical distribution of resistance determinant markers. This volume should be a useful guide for microbiologists and clinicians interested in designing antimicrobial th

Multidrug resistance. --- Multi-drug resistance --- Multiple drug resistance --- Pleiotropic drug resistance --- Drug resistance

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ATP-Binding Cassette Transporters --- Drug Resistance, Multiple. --- Ovarian Neoplasms --- P-Glycoprotein --- Heat-Shock Proteins --- Multi-Drug Resistance --- Multidrug Resistance --- Multiple Drug Resistance --- Resistance, Multiple Drug --- P-Glycoproteins --- Genes, MDR --- Multidrug Resistance-Associated Proteins --- chemistry. --- drug therapy. --- analysis. --- Theses --- ATP Binding Cassette Transporter, Sub-Family B --- ATP-Binding Cassette, Sub-Family B, Member 1 --- ATP Binding Cassette Transporter, Subfamily B --- ATP Binding Cassette Transporter, Subfamily B, Member 1 --- Drug Resistance, Multiple --- ABCB1 Protein --- ATP Binding Cassette Transporter, Sub-Family B, Member 1 --- CD243 Antigen --- PGY-1 Protein --- MDR1 Protein --- Multidrug Resistance Protein 1 --- Antigen, CD243 --- P Glycoprotein --- PGY 1 Protein --- Rhodamine 123 --- chemistry --- drug therapy --- analysis

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This book provides new structural, biochemical, and clinical information on ABC transporters. The authors explore and describe the state of the art of research, knowledge, and prospects for the future for this important family of proteins. The first ABC transporter was discovered in 1973 and was named P-glycoprotein. It elicits resistance to cytotoxic drugs, chiefly in human tumours, within which chemotherapy failure is observed in about 50% of cases. Together with its complex pharmacology, and even a suspected role in Alzheimer’s disease, this ABC transporter still eludes a clinical solution to its multidrug resistance property. ABC transporters are integral membrane active proteins and they belong to one of the largest protein families across all species. Their myriad roles encompass the import or export of a diverse range of allocrites, including ion, nutrients, peptides, polysaccharides, lipids, and xenobiotics. They are of major medical importance with many members elaborating multidrug resistance in bacteria, fungi, yeast, parasites, and humans. Other ABC transporters are involved in a number of inherited diseases, including cystic fibrosis, macular degeneration, gout, and several other metabolic disorders.

Cytology --- Biology --- Health & Biological Sciences --- Multidrug resistance. --- ATP-binding cassette transporters. --- ABC proteins --- ABC transporters --- ATP-binding cassette proteins --- Multi-drug resistance --- Multiple drug resistance --- Pleiotropic drug resistance --- Carrier proteins --- Membrane proteins --- Drug resistance --- Cell membranes. --- Biochemistry. --- Drug interactions. --- Membrane Biology. --- Biological and Medical Physics, Biophysics. --- Biochemistry, general. --- Drug Resistance. --- Interactions, Drug --- Drugs --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medical sciences --- Cell surfaces --- Cytoplasmic membranes --- Plasma membranes --- Plasmalemma --- Membranes (Biology) --- Glycocalyces --- Side effects --- Composition --- Cell membranes . --- Biophysics. --- Biological physics. --- Drug resistance. --- Resistance to drugs --- Pharmacology --- Biological physics --- Physics