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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact

multicellularity --- in vitro 3D modelling --- Stem Cells --- engineered cardiovascular tissues --- cardiomyocytes

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Engineering Multicellular Systems: Methods and Protocols, focuses on laboratory procedures used in recent efforts for constructing synthetic multicellular systems and their applications. In particular, constructing multicellular systems to form various microbial ecosystems has been extensively explored to examine evolution and interactions of microbial ecosystems, while co-cultures have emerged as an efficient tool to produce some complex chemical molecules. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.   Engineering Multicellular Systems: Methods and Protocols provides a comprehensive laboratory protocol reference for constructing multicellular systems for various applications.

Biotechnology. --- Biochemical engineering. --- Biochemical Engineering. --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Biotechnology --- Chemical engineering --- Genetic engineering --- Multicellularity. --- Cells

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"The first work to explore the major evolutionary transitions in organismal complexity, the many and important roles of individuality, and the relationship between individuals and species"--

Life (Biology) --- Individuality. --- Philosophy. --- Psychology --- Conformity --- Identity (Psychology) --- Likes and dislikes --- Personality --- Self --- Major transitions in evolution --- individuality --- multicellularity --- superorganismality --- Julian Huxley --- history of biology --- SCIENCE / Life Sciences / Evolution --- SCIENCE / Life Sciences / Biology --- SCIENCE / History

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The evolution of multicellularity raises questions regarding genomic and developmental commonalities and discordances, selective advantages and disadvantages, physical determinants of development, and the origins of morphological novelties. It also represents a change in the definition of individuality, because a new organism emerges from interactions among single cells. This volume considers these and other questions, with contributions that explore the origins and consequences of the evolution of multicellularity, addressing a range of topics, organisms, and experimental protocols.Each section focuses on selected topics or particular lineages that present a significant insight or challenge. The contributors consider the fossil record of the paleontological circumstances in which animal multicellularity evolved; cooptation, recurrent patterns, modularity, and plausible pathways for multicellular evolution in plants ; theoretical approaches to the amoebozoa and fungi (cellular slime molds having long provided a robust model system for exploring the evolution of multicellularity), plants, and animals; genomic toolkits of metazoan multicellularity ; and philosophical aspects of the meaning of individuality in light of multicellular evolution.

Evolution (Biology) --- Cells --- Self-organizing systems. --- Learning systems (Automatic control) --- Self-optimizing systems --- Cybernetics --- Intellect --- Learning ability --- Synergetics --- Cell evolution --- Cellular evolution --- Animal evolution --- Animals --- Biological evolution --- Darwinism --- Evolutionary biology --- Evolutionary science --- Origin of species --- Biology --- Evolution --- Biological fitness --- Homoplasy --- Natural selection --- Phylogeny --- Evolution. --- Paleobotany. --- Paleoecology. --- Plants --- BIOMEDICAL SCIENCES/Evolution --- BIOMEDICAL SCIENCES/General --- Plant evolution --- Palaeoecology --- Ecology --- Paleobiology --- Fossil botany --- Palaeobotany --- Botany --- Paleontology --- Multicellularity. --- Self-organizing systems --- Developmental Biology --- Morphogenesis --- Cell interaction --- Growth and Development. --- Eukaryota. --- Physiological Phenomena. --- Genetic Phenomena. --- Biological Phenomena. --- Biological Science Disciplines. --- Organisms --- Cell Physiological Phenomena. --- Natural Science Disciplines. --- Biophysics --- Paleobotany --- Geology --- Molecular evolution. --- Biocomplexity. --- Growth and Development --- Eukaryota --- Physiological Phenomena --- Genetic Phenomena --- Biological Science Disciplines --- Cell Physiological Phenomena --- Natural Science Disciplines