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This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility. Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
Life Sciences. --- Proteomics. --- Hematology. --- Cell Biology. --- Life sciences. --- Cytology. --- Sciences de la vie --- Hématologie --- Protéomique --- Cytologie --- Thrombotic thrombocytopenic purpura. --- Von Willebrand disease. --- Biochemistry --- Chemistry --- Physical Sciences & Mathematics --- Disseminated arteriolar-capillary platelet thrombosis --- Febrile pleiochromic anemia --- Microangiopathic hemolytic anemia --- Moschcowitz disease --- Moschcowitz syndrome --- Moschcowitz's disease --- Platelet thrombosis --- Thrombotic microangiopathic hemolytic anemia --- Thrombotic microangiopathy --- Thrombotic thrombocytic anemia --- Thrombotic thrombohemolytic purpura --- TTP (Disease) --- Angiohemophilia --- Hemophilia, Vascular --- Hereditary pseudohemophilia --- Pseudohemophilia, Hereditary --- Vascular hemophilia --- Von Willebrand's disease --- Willebrand syndrome --- Willebrand's syndrome --- Cell biology. --- Hemolytic anemia --- Thrombopenic purpura --- Thrombosis --- Blood coagulation disorders --- Genetic disorders --- Hemorrhagic diseases --- Cell biology --- Cellular biology --- Biology --- Cells --- Cytologists --- Haematology --- Internal medicine --- Blood --- Molecular biology --- Proteins --- Diseases
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"This reference presents detailed discussions of the history, pathology, pathophysiology, and approaches to treatment of the complicated, constantly evolving syndromes known as thrombotic thromocytopenic purpura (TTP), from many different points of view. Hemolytic Uremic syndrome and Thrombotic Thrombocytopenic Purpura offers: extensive analyses of the relationship between HUS and TTP; epidemiological studies of HUS from the UK, Canada, Asia, South Africa and Argentina; investigations of non-renal complications of HUS; perspectives on atypical HUS and post-transplantation HUS; delineations of the association between verotoxin and HUS, HUS and pregnancy, and HUS and cancer and cancer tharapy; information on HUS/TTP in HIV-infected patients; explications of the pathology and pathogenesis of HUS; and approaches to treatment of HUS, prognosis, and long-term follow-up.; In addition, it covers the history and pathogenesis of TTP, von Willebrand factor abnormalities in TTP and HUS, platelet agglutinating proteins in TTP, and the treatment of TTP.; With over 2000 literature citations and figures, this book is for nephrologists, hematologists, oncologists, paediatricians, pathologists, gastroenterologists, internists, endocrinologists, infectious disease specialists, neurologists, gynaecologists, microbiologists, surgeons, geneticsts, epidemiologists, radiologists, and medical school students in these disciplines."--Publisher description.
Hemolyse-uremic"syndroom --- Hemolytic-uremic syndrome --- Hemolytique-uremique [Syndrome ] --- Purpura thrombocytopénique thrombotique --- Thrombotic thrombocytopenic purpura --- Trombocytopenische trombotische purpura --- Hemolytic-Uremic Syndrome --- Purpura, Thrombotic Thrombocytopenic --- Child --- Infant --- Infants --- Children --- Minors --- Congenital Thrombotic Thrombocytopenic Purpura --- Familial Thrombotic Thrombocytopenia Purpura --- Familial Thrombotic Thrombocytopenic Purpura --- Microangiopathic Hemolytic Anemia, Congenital --- Moschcowitz Disease --- Schulman-Upshaw Syndrome --- Thrombotic Microangiopathy, Familial --- Thrombotic Thrombocytopenic Purpura --- Upshaw Factor, Deficiency of --- Upshaw-Schulman Syndrome --- Moschkowitz Disease --- Purpura, Thrombotic Thrombopenic --- Thrombotic Thrombocytopenic Purpura, Congenital --- Thrombotic Thrombocytopenic Purpura, Familial --- Disease, Moschcowitz --- Disease, Moschkowitz --- Familial Thrombotic Microangiopathy --- Microangiopathy, Familial Thrombotic --- Schulman Upshaw Syndrome --- Syndrome, Schulman-Upshaw --- Syndrome, Upshaw-Schulman --- Thrombocytopenic Purpura, Thrombotic --- Thrombopenic Purpura, Thrombotic --- Thrombotic Thrombopenic Purpura --- Upshaw Schulman Syndrome --- Disseminated arteriolar-capillary platelet thrombosis --- Febrile pleiochromic anemia --- Microangiopathic hemolytic anemia --- Moschcowitz disease --- Moschcowitz syndrome --- Moschcowitz's disease --- Platelet thrombosis --- Thrombotic microangiopathic hemolytic anemia --- Thrombotic microangiopathy --- Thrombotic thrombocytic anemia --- Thrombotic thrombohemolytic purpura --- TTP (Disease) --- Hemolytic anemia --- Thrombopenic purpura --- Thrombosis --- Gasser syndrome --- Gasser's syndrome --- HUS (Disease) --- Uremic-hemolytic syndrome --- Acute renal failure --- Blood platelet disorders --- Syndromes --- Uremia --- Gasser Syndrome --- Gasser's Syndrome --- Gassers Syndrome --- Hemolytic Uremic Syndrome --- Syndrome, Hemolytic-Uremic --- Hemolytic-uremic syndrome. --- Thrombotic thrombocytopenic purpura. --- In infancy & childhood.
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