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Improving psychological well-being and cognitive health is now listed as the priority on the healthy aging agenda. Depression and cognitive impairment are great challenges for the elderly population. There have been numerous studies on depression and cognitive impairment and dementia. However, the neural correlates of depression and cognitive impairment have not yet been elucidated. With the development of neuroscience and relevant technologies, studies on anatomical and functional neural networks, neurobiological mechanisms of mood and cognition in old age will provide more insight into the potential diagnosis, prevention and intervention in depression and cognitive impairment. For example, longitudinal neuroimaging studies depicting the trajectories of patterns of structural and functional brain networks of mild cognitive impairment may provide potential imaging markers for the onset of dementia. Population-based studies have addressed the potential interaction between mood and cognitive impairment in old age. However, there are few studies to explore the potential neural mechanism of the relationship between depression and cognitive impairment in old age. In all of this process the contribution of multiple biological events cannot be neglected, particularly the underlying influence of chronic diseases and concomitant polymedication as well as the geriatric conditions, like frailty, frequently present in this elderly population, which also compromise the cognitive function and mood determining depression and conducing to worse outcomes with more morbidity and mortality.

mood disorder --- mild cognitive impairment --- Alzheimer

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Affective disorders --- Troubles affectifs --- Mood Disorders. --- Affective Disorders --- Affective Disorder --- Disorder, Affective --- Disorder, Mood --- Disorders, Affective --- Disorders, Mood --- Mood Disorder --- Mood Disorders --- Mood disorders --- Psychology, Pathological

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"It is estimated that as many as fifty percent of patients initially diagnosed with major Unipolar depression (UP, MDD) will subsequently incur a manic episode or discover a past subtle episode and will have had Bipolar depression rather than MDD. The average Bipolar individual suffers with episodic symptoms for ten years before receiving an accurate diagnosis. As many as 16 million individuals in the United States will have a Bipolar episode in their lives, diagnosed or not. With the recognition of these growing numbers of patients with a Bipolar Disorder, it is imperative that patients are diagnosed and treated earlier, accurately and efficiently. Untreated Bipolar usually gets worse. Bipolar aims to improve recognition, acceptance, and compliance. Dr. C. Raymond Lake applies two different approaches , comprehensive research and case studies, to the understanding of Bipolar Disorders, presenting basic, selected Bipolar data including history, diagnostic criteria, definitions of terms, and classifications, as well as management and treatment strategies to help the reader fully comprehend the disorder. In addition, case studies provide the reader with real-life examples to help increase recognition of various Bipolar presentations beyond the stark black-and-white diagnostic criteria of the DSM and ICD"--

Manic-depressive illness --- Bipolar Disorder. --- Diagnosis. --- Psychoses, Manic-Depressive --- Affective Psychosis, Bipolar --- Bipolar Mood Disorder --- Depression, Bipolar --- Manic Depression --- Manic Disorder --- Manic-Depressive Psychosis --- Psychosis, Manic-Depressive --- Bipolar Affective Psychosis --- Bipolar Depression --- Bipolar Disorders --- Bipolar Mood Disorders --- Depression, Manic --- Depressions, Manic --- Disorder, Bipolar --- Disorder, Bipolar Mood --- Disorder, Manic --- Manic Depressive Psychosis --- Manic Disorders --- Mood Disorder, Bipolar --- Psychoses, Bipolar Affective --- Psychoses, Manic Depressive --- Psychosis, Bipolar Affective --- Psychosis, Manic Depressive --- Bipolar depression --- Bipolar disorder --- Manic depression --- Manic-depressive psychoses --- Manic-depressive psychosis --- Melancholia --- Affective disorders --- Psychoses --- Depression, Mental --- Mania --- Affective psychoses, Bipolar --- Bipolar mood disorder --- Psychoses, Manic-depressive

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Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness.Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomicsExamines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorderExplores the interaction between genomic and environmental influences that shape behavior.

Manic-depressive illness --- Etiology. --- Bipolar depression --- Bipolar disorder --- Depression, Bipolar --- Depression, Manic --- Manic depression --- Manic-depressive psychoses --- Manic-depressive psychosis --- Melancholia --- Affective disorders --- Psychoses --- Depression, Mental --- Mania --- Affective psychoses, Bipolar --- Bipolar mood disorder --- Psychoses, Manic-depressive

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Recent years have brought a striking increase in the number of psychosocial treatment studies of bipolar disorder and cognitive-behavioural approaches have been prominent among these studies with clear evidence that interest in this approach is rising among experts in bipolar disorder. Studies of CBT treatment of bipolar disorder have shown dramatic effects with relapse rates significantly lower (44% vs. 75%) than with comparison treatments. This book is a self-directed, relapse prevention for individuals living with bipolar disorder. It uses the collaborative care model to allow individuals l

Manic-depressive illness --- Bipolar disorder --- Affective psychoses, Bipolar --- Bipolar depression --- Bipolar mood disorder --- Depression, Bipolar --- Depression, Manic --- Manic depression --- Manic-depressive psychoses --- Manic-depressive psychosis --- Melancholia --- Psychoses, Manic-depressive --- Affective disorders --- Psychoses --- Depression, Mental --- Mania