Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Discussing the systemic immune response in the contexts of health, disease, and therapy, this unique resource-the only broadly based book of its kind available on the subject-offers comprehensive examinations of the pathways and agents that affect the human immune response and provides state-of-the-art presentations on practical methods of immune modulation. Focuses on the immune response and modulation in infectious diseases, such as HIV, hepatitis, and parasitic infections and highlights immune modulating agents in gastrointestinal diseases, sepsis, cancer, and autoimmunity! Written by over 50 international authorities representing distinguished institutions in nine countries, Immune Modulating Agentsintroduces basic immunoregulatory mechanisms as homeostasis details cytokines, cellular and humoral immune responses, and hematopoiesis describes neuroendocrine - immune system interactions and the role of psychological stress on immune competence delineates factors that influence disease susceptibility, including nutrition covers drug delivery systems, gene therapy, organ transplantation, arthritis treatment, and vaccination strategies shows how to design clinical trials using immune modulating agents and more!

Immune response --- Biological response modifiers. --- Regulation. --- Biomolecules --- Cancer --- Cellular control mechanisms --- Immunopharmacology --- Biological response modulators --- Biomodulators --- BRMs (Biochemistry) --- Immunomodulators --- Immunoregulators --- Modifiers, Biological response --- Modulators, Biological response --- Idiotypic networks --- Biological response modifiers --- Ir genes --- Immune modulation --- Immunity --- Immunomodulation --- Immunoregulation --- Regulation of immunity --- Regulation of the immune response --- Immunotherapy --- Regulation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

therapeutics --- pharmacology --- antibodies --- Immunoglobulins --- Antibodies --- Immunologic Factors. --- Therapeutic use. --- therapeutic use. --- Biological Response Modifiers --- Biomodulators --- Factors, Immunologic --- Immune Factors --- Immunological Factors --- Modifiers, Biological Response --- Response Modifiers, Biological --- Immunomodulators --- Factors, Immune --- Factors, Immunological --- Receptors, Immunologic --- Molecular Mechanisms of Pharmacological Action --- Immune globulins --- Immune serum globulin --- Blood proteins --- Globulins --- Plasma cells --- Antibody diversity --- Antigens --- Bacterial immunoglobulin-binding proteins --- Biological Response Modifier --- Biomodulator --- Immune Factor --- Immunological Factor --- Immunomodulator --- Factor, Immune --- Factor, Immunological --- Modifier, Biological Response --- Response Modifier, Biological

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

"Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert" immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines."

Biomedical materials. --- Immune response --- Regulation. --- Immune modulation --- Immunity --- Immunomodulation --- Immunoregulation --- Regulation of immunity --- Regulation of the immune response --- Idiotypic networks --- Biological response modifiers --- Ir genes --- Bioartificial materials --- Biocompatible materials --- Biomaterials (Biomedical materials) --- Hemocompatible materials --- Medical materials --- Medicine --- Biomedical engineering --- Materials --- Biocompatibility --- Prosthesis --- Regulation --- Biological response modifiers. --- Biological response modulators --- Biomodulators --- BRMs (Biochemistry) --- Immunomodulators --- Immunoregulators --- Modifiers, Biological response --- Modulators, Biological response --- Biomolecules --- Cancer --- Cellular control mechanisms --- Immunopharmacology --- Immunotherapy

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Pathogen-Derived Immunomodulatory Molecules is a book title that may require some explanation. Pathogens that are present today have evolved following a long association with man and have developed unique strategies that have been optimized by natural selection to subvert the host immunity. As we approach the 200th anniversary of Charles Darwin’s birth, it is appropriate to appreciate that Darwin recognized that pathogens (infections) play a significant and potent role in natural selection, encompassed by the concept “infection begets natural selection”. This book therefore examines the molecules that pathogens produce, which can modulate or usurp the functions of the immune system. The idea of using molecules from pathogens as a therapeutic is an ancient concept in medicine. Such a strategy is exemplified by vaccination, with pathogen molecules employed to induce protective immunity against the given or related species of pathogen. The following chapters explore the concept of using pathogen-derived immune modulating molecules as a therapy. In doing so, they may provide the drug cabinet of the future for treating a spectrum of unrelated disease. Herein, a range of immune modulating molecules or strategies from various pathogens is examined in one volume. The intention of the book was to have chapters addressing immunomodulating molecules from different pathogens. The range of pathogens considered includes bacteria (chapters by Williams, van Strijp and Rooijakkers), viruses (chapters by Bowie, McFadden), protozoan parasites (Aliberti), helminths (Harnett, Fallon), fungi (Sorrell) and parasitic ticks (Anguita). Chapters also address specific immunomodulatory molecules or strategies. The diversity of aspects addressed in the book is highlighted by Lucas and colleagues review of the ‘saga’ of viral serine proteinase inhibitors, with a focus on Serp-1, the first new generation of pathogen immunomodulatory molecule currently in clinical trials. While Elliott and Weinstock have contributed a provocative chapter exploring the use of live parasitic helminth infections as a therapeutic strategy for immune-mediated diseases; indeed trials have already been completed for such an approach. With respect to pathogens usurping an immune pathway, Alcami and colleagues here reviewed the growing number of pathogens that have evolved a range of molecules that can modify many aspects of the chemokine system. This book is timely due to the need to expand the horizons of conventional drug discovery. A trend in the biopharmaceutical pipeline of fewer drugs to market is illustrated by USA FDA in 2007 approving the lowest number of new molecular entities since 1983. As the drug discovery and development industry broadens its search for new drugs to less traditional strategies, this book will be a reference to the potential for exploiting pathogen as a source of the anti-inflammatory drugs of the future. Finally, this book whets the appetite for the reader, whether in academia or industry, to explore opportunities for exploiting pathogens for the discovery of new processes in immunobiology and, ultimately, for development of new therapies for human inflammatory diseases.

Pathogenic microorganisms --- Biological response modifiers --- Microbiological Phenomena --- Immunologic Factors --- Phenomena and Processes --- Physiological Effects of Drugs --- Pharmacologic Actions --- Chemical Actions and Uses --- Chemicals and Drugs --- Microbiology & Immunology --- Biology --- Health & Biological Sciences --- Pathogenic microorganisms. --- Biological response modifiers. --- Biological response modulators --- Biomodulators --- BRMs (Biochemistry) --- Immunomodulators --- Immunoregulators --- Modifiers, Biological response --- Modulators, Biological response --- Disease-causing microorganisms --- Micro-organisms, Pathogenic --- Pathogens --- Medicine. --- Biomedicine. --- Biomedicine general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomolecules --- Cancer --- Cellular control mechanisms --- Immunopharmacology --- Immune response --- Microorganisms --- Medical microbiology --- Virulence (Microbiology) --- Immunotherapy --- Regulation

Choose an application

• Reference Manager
• EndNote
• RefWorks (Direct export to RefWorks)

Biological response modifiers --- Cancer --- Immunity, Cellular --- Immunotherapy --- Neoplasms --- Cellular Immune Response --- Cell-Mediated Immunity --- Cell Mediated Immunity --- Cell-Mediated Immunities --- Cellular Immune Responses --- Cellular Immunities --- Cellular Immunity --- Immune Response, Cellular --- Immune Responses, Cellular --- Immunities, Cell-Mediated --- Immunities, Cellular --- Immunity, Cell-Mediated --- Response, Cellular Immune --- Lymphokines --- T-Lymphocytes --- Interleukin-12 --- Biological response modulators --- Biomodulators --- BRMs (Biochemistry) --- Immunomodulators --- Immunoregulators --- Modifiers, Biological response --- Modulators, Biological response --- Biomolecules --- Cellular control mechanisms --- Immunopharmacology --- Immune response --- Immunotherapies --- Immunity, Active --- Immunologic Techniques --- immunology --- therapy --- Immunological aspects --- Treatment --- Regulation --- Combined Antibody Therapeutics --- IMMUNOTHERAPY --- NEOPLASMS --- xxx