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This work addresses major challenges of heart model personalization. Analysis techniques for clinical intracardiac electrograms determine wave direction and conduction velocity from single beats. Electrophysiological measurements are simulated to validate the models. Uncertainties in tissue conductivities impact on simulated ECGs. A minimal model of cardiac myocytes is adapted to the atria. This makes personalized cardiac models a promising technique to improve treatment of atrial arrhythmias.

Atrial fibrillation --- Intracardiac electrograms --- Model personalization --- Cardiac modelling --- Electroyphsiology

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This book includes a selection of papers showing the potential of the dynamic modelling approach to treat problems related to the musculoskeletal system. The state-of-the-art is presented in a review article and in a perspective paper, and several examples of application in different clinical problems are provided.

Information technology industries --- musculoskeletal model --- pregnancy --- motion analysis --- muscle load evaluation --- low back pain --- deglutition --- muscle activity --- simulation --- swallowing biomechanics --- musculoskeletal modelling --- musculoskeletal simulations --- clinical research --- rehabilitation --- biomechanics --- rectus femoris --- foot kinematics --- knee kinematics --- normal gait --- gait cycle --- forward modeling --- musculoskeletal modeling --- neuromusculoskeletal model --- computational model --- model personalization --- treatment optimization --- treatment design --- predictive simulation --- human movement --- total hip replacement --- hip dysplasia --- hip abductor muscles --- gait analysis --- knee joint ligaments --- walking --- dynamic simulation --- knee joint biomechanics --- polyethylene thickness --- total knee arthroplasty --- ligament forces --- compressive forces --- patellar kinematics --- musculoskeletal model --- pregnancy --- motion analysis --- muscle load evaluation --- low back pain --- deglutition --- muscle activity --- simulation --- swallowing biomechanics --- musculoskeletal modelling --- musculoskeletal simulations --- clinical research --- rehabilitation --- biomechanics --- rectus femoris --- foot kinematics --- knee kinematics --- normal gait --- gait cycle --- forward modeling --- musculoskeletal modeling --- neuromusculoskeletal model --- computational model --- model personalization --- treatment optimization --- treatment design --- predictive simulation --- human movement --- total hip replacement --- hip dysplasia --- hip abductor muscles --- gait analysis --- knee joint ligaments --- walking --- dynamic simulation --- knee joint biomechanics --- polyethylene thickness --- total knee arthroplasty --- ligament forces --- compressive forces --- patellar kinematics