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Discrimination of mobile supramolecular chirality : acylative molecular transformations by organocatalysis
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ISBN: 9811674302 9811674310 Year: 2022 Publisher: Singapore : Springer,

Chirality in industry : The commercial manufacture and applications of optically active compounds.
Authors: --- ---
ISBN: 0471935956 0471966800 0471963135 9780471935957 9780471963134 Year: 1992 Publisher: Chichester : Wiley,


Book
Key chiral auxiliary applications
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ISBN: 012417115X 012417034X 9780124170346 Year: 2014 Publisher: Waltham, [Massachusetts] ; Amsterdam, The Netherlands : Academic Press,

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Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of resul


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Chiral recognition in separation methods : mechanisms and applications
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ISBN: 3642423698 3642124445 9786612980800 3642124453 1282980807 Year: 2010 Publisher: New York : Springer,

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The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the first time, a team of experienced analysts from industry and academe presents a comprehensive review of the various mechanisms that result in enantiomer separations. A better understanding of these processes is crucial for setting as well as improving chiral separation procedures and also for developing new applications. The coverage in this book includes a range of separation methods, such as gas, liquid, or countercurrent chromatography, and capillary electrophoresis. The special case of chiral ionic liquids is examined in detail. Most modern chiral selectors are discussed, including derivatized polysaccharide- and cyclodextrin-based selectors, along with a newly introduced class of carbohydrates: the cyclofructose selectors. This publication will be required reading not only for research and development departments in the pharmaceutical and cosmetic industries, but also for researchers in toxicology, environmental monitoring, and food research.


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Development of Chemistry-Based Screening Platform for Access to Mirror-Image Library of Natural Products
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ISBN: 981106623X 9811066221 Year: 2018 Publisher: Singapore : Springer Singapore : Imprint: Springer,

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This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested only natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an α-tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.


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Chiral environmental pollutants : analytical methods, environmental implications and toxicology
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ISBN: 3030624560 3030624552 Year: 2021 Publisher: Cham, Switzerland : Springer,

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Now in its updated second edition, this book describes emerging chiral environmental pollutants and their importance in environmental and human toxicology, as well as enantiomer selective separation and analytical methods. Compared to the first edition from 2001, the book has been completely restructured and a wealth of new material has been added to account for new developments. The book reports on the modern enantiomer selective separation methods, including enantio-selective chromatography techniques, which have even been successfully tested in space during the ESA Rossetta mission. The authors clearly outline why the topic of chiral environmental pollutants has become even more important: many new chiral compounds have been released in recent years (e.g. as new pharmaceuticals or agrochemicals), and traces of these compounds can now be found in the environment. The authors explain that (and how) chirality can be a very important feature for the bioactivity of anthropogenic pollutants. In this book, readers find an introduction to the topic, including all important aspects, from the introduction of new enantiomer selective analytical methods, and of emerging chiral environmental pollutants, to aspects on environmental and human toxicology and exposure, risk assessment, and aspects on climate change as well as other new aspects on chirality in the environment. The book is thus a must-read for everybody working in the field of chiral environmental pollutants, but it is also beneficial for teaching purposes in specialized post-graduate courses in advanced analytical chemistry, pharmaceutical analytics, or environmental chemistry.


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Mirrors of entrapment and emancipation : Forugh Farrokhzad and Sylvia Plath
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ISBN: 9087282966 9400602073 9087282249 Year: 2015 Publisher: [Leiden] : Leiden University Press,

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Mirrors of Entrapment and Emancipation explores the rich diversity of the meanings associated with the mirror and reflection in literature by women on the basis of the works of the Persian Forugh Farrokhzad (1935-1967) and her American contemporary Sylvia Plath (1932-1963). These two poets astutely employed mirror images for the realization as well as for communication of their turbulent psycho-emotional states to their readers, thereby capturing and conveying the essence of women desperately trapped among the antithetical images of twentieth-century womanhood.


Book
Differentiation of Enantiomers I
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ISBN: 3319032380 3319032399 9783319032382 Year: 2013 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science.The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Keywords

Chemistry. --- Medicine. --- Analytical biochemistry. --- Chemistry, Organic. --- Organic Chemistry. --- Analytical Chemistry. --- Biomedicine general. --- Chromatographic analysis --- Enantiomers --- Isomerism --- Organic Chemistry Phenomena --- Chemical Phenomena --- Phenomena and Processes --- Stereoisomerism --- Chemistry --- Physical Sciences & Mathematics --- Biochemistry --- Analysis --- Differentiation --- Stereochemistry, Molecular --- Molecular Stereochemistry --- Stereoisomers --- Stereoisomer --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Organic Chemistry Phenomenon --- Organic Chemistry Process --- Organic Chemistry Concepts --- Organic Chemistry Processes --- Chemistry Process, Organic --- Chemistry Processes, Organic --- Concept, Organic Chemistry --- Concepts, Organic Chemistry --- Organic Chemistry Concept --- Phenomena, Organic Chemistry --- Phenomenon, Organic Chemistry --- Process, Organic Chemistry --- Processes, Organic Chemistry --- Isomerisms --- Antipodes, Optical --- Enantiomorphs --- Isomers, Mirror-image --- Mirror-image isomers --- Optical antipodes --- Analysis, Chromatographic --- Chromatography --- Organic chemistry --- Analytic biochemistry --- Clinical sciences --- Medical profession --- Analytical chemistry. --- Organic chemistry. --- Chromatographic analysis. --- Analysis. --- Differentiation. --- Optical isomers --- Chirality --- Chemistry, Analytic --- Phase partition --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biomedicine, general. --- Health Workforce --- Analytical chemistry --- Analysis, Chemical --- Analytic chemistry --- Chemical analysis --- Medicine --- Analytical biochemistry --- Chemistry, Organic

Images in mind : statues in archaic and classical Greek literature and thought
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ISBN: 0691044317 069121848X 0691094888 Year: 2001 Publisher: Princeton (N.J.) : Princeton university press,

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In archaic and classical Greece, statues played a constant role in people's religious, political, economic, aesthetic, and mental lives. Evidence of many kinds demonstrates that ancient Greeks thought about--and interacted with--statues in ways very different from our own. This book recovers ancient thinking about statues by approaching them through contemporary literary sources. It not only shows that ancient viewers conceived of images as more operative than aesthetic, but additionally reveals how poets and philosophers found in sculpture a practice ''good to think with.'' Deborah Tarn Steiner considers how Greek authors used images to ponder the relation of a copy to an original and of external appearance to inner reality. For these writers, a sculpture could straddle life and death, encode desire, or occasion reflection on their own act of producing a text. Many of the same sources also reveal how thinking about statues was reflected in the objects' everyday treatment. Viewing representations of gods and heroes as vessels hosting a living force, worshippers ritually washed, clothed, and fed them in order to elicit the numinous presence within. By reading the plastic and verbal sources together, this book offers new insights into classical texts while illuminating the practices surrounding the design, manufacture, and deployment of ancient images. Its argument that images are properly objects of cultural and social--rather than purely aesthetic--study will attract art historians, cultural historians, and anthropologists, as well as classicists.

Keywords

Statues in literature --- Statues dans la littérature --- Art et littérature --- Sculpture in literature. --- Sculpture, Greek, in literature. --- Statues in literature. --- Statues dans la littérature --- Art and literature --- Greek literature --- Statues --- History and criticism. --- Sculpture in literature --- Aesthetics, Ancient. --- Sculpture, Greek. --- Littérature grecque --- Art et littérature --- Sculpture dans la littérature --- Esthétique ancienne --- Sculpture grecque --- Histoire et critique --- Statuary --- Monuments --- Sculpture --- Literature and art --- Literature and painting --- Literature and sculpture --- Painting and literature --- Sculpture and literature --- Aesthetics --- Literature --- Achilles. --- Admetus. --- Alcibiades. --- Daidalos. --- Dionysus. --- Gorgias. --- Gorgon. --- Harmodios and Aristogeiton. --- Helen. --- Hephaistos. --- Hermes. --- Kronos. --- Leagros. --- Lucian. --- Lykosura. --- Menelaus. --- Nike. --- Niobe. --- Odysseus. --- Pandora. --- Pelops. --- Pindar. --- Socrates. --- athletic images. --- base, of statue. --- blindness. --- chariot race. --- charis. --- civic life. --- cult images. --- daidalon. --- eikones. --- eros. --- facture. --- festivals. --- funerary monuments. --- homosocial relations. --- idealization. --- immobility. --- ivory. --- korai. --- mirror image. --- mobility. --- realism. --- summetria. --- Standbeelden. --- Plastische kunst. --- Interactie. --- Griekse oudheid. --- Bellettrie. --- Beeldvorming.

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