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In recent years, researchers have shown a special interest in natural products as alternative methods for the prevention, treatment, and/or management of various skin illnesses and disorders, primarily due to their natural availability, efficacity, reduced cost, and minimal toxicity. In a similar vein, synthetic bioactives, as well as small molecules, have been studied in vitro, in vivo, and in clinical studies as potential drugs or supplements. This Special Issue of Nutrients comprises an array of literature reviews, original communications, and studies on the roles of natural products, synthetic bioactives, and small molecules in a variety of skin disorders and diseases, such as aging, atopic dermatitis, cutaneous T-cell lymphomas, melanoma, allergies, hyperpigmentation, inflammation, and more, which were investigated through in vitro and ex vivo approaches, preclinical trials, cell-based assays, and animal models. The mechanisms of action of certain compounds are proposed, while others are currently under investigation. The authors of the papers also explore technologies designed to improve the bioavailability and delivery of certain compounds. In lieu of ongoing research on a variety of skin disorders, the wealth of information published in this Special Issue can act as a springboard for the development of new preventive and therapeutic modalities for the management of skin diseases.

Research & information: general --- Biology, life sciences --- keratinocytes --- rutin --- ascorbic acid --- UV radiation --- proteomics --- 3D cell culture --- borage oil --- triacylglycerol metabolism --- acyl-ceramide --- corneocyte lipid envelope --- epidermis --- anti-melanogenesis --- B16/F10 melanoma cell --- hydroxyoctadecadienoic acid --- Sorghum bicolor --- 3-isobutyl-1-methylxanthine --- mycosis fungoides --- atopic dermatitis --- cutaneous lymphomas --- cornified envelope proteins --- FLG --- microalgae --- Planktochlorella nurekis --- skin cells --- proliferation --- senescence --- holothuroids --- glycosaminoglycans --- inflammation --- ear-inflammation --- whey --- Lactobacillus helveticus --- melanin --- α-melanocyte-stimulating hormone --- tyrosinase --- tyrosinase-related protein 1 --- dopachrome tautomerase --- microphthalmia-associated transcription factor --- cosmetics --- black cumin --- Nigella sativa --- Thymocid® --- skin aging --- glycation --- collagen --- collagenase --- elastase --- melanogenesis --- cosmeceutical --- konjac glucomannan --- ultraviolet B --- human epidermal primary melanocytes --- human embryonic fibroblasts --- anti-inflammatory activity --- antioxidant activity --- Cornus officinalis --- molecular docking --- human high-affinity IgE receptors --- α-MSH --- UVB irradiation --- lotus seedpod extract --- epigallocatechin --- propolis --- skin --- matrix metalloproteinase-1 --- UV --- phosphoinositide 3-kinase --- skin care --- skin health --- bioactive substances --- phytonutrients --- antioxidants --- nutraceuticals --- Perilla frutescens --- cell proliferation --- ultraviolet radiation --- DNA repair --- Lactobacillus plantarum CJLP55 --- acne vulgaris --- sebum --- hydration --- urine bacterial extracellular vesicles --- fungal infections --- nanohydrogel --- polysaccharide --- essential oils --- eggshell membrane --- keratinocyte differentiation --- TRPV --- skin thickness --- Lithospermum erythrorhizon --- NC/Nga --- Th1 --- Th2 --- Th17 --- Th22 --- immune balance --- skin barrier function --- n/a