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Bacterial invasion of host cells
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ISBN: 1107144124 1280457813 9786610457816 0511185979 0511185146 0511187823 0511313829 0511546270 0511186894 Year: 2004 Publisher: Cambridge : Cambridge University Press,

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Abstract

This book concerns the intimate association between bacteria and host cells. Many bacterial pathogens are able to invade and survive within cells at mucosal membranes. Remarkably, the bacteria themselves orchestrate this process through the exploitation of host cellular signal transduction pathways. Intracellular invasion can lead to disruption of host tissue integrity and perturbation of the immune system. An understanding of the molecular basis of bacterial invasion and of host cell adaptation to intracellular bacteria will provide fundamental insights into the pathophysiology of bacteria and the cell biology of the host. The book details specific examples of bacteria that are masters of manipulation of eukaryotic cell signaling and relates these events to the broader context of host-pathogen interaction. Written by experts in the field, this book will be of interest to researchers and graduate students in microbiology, immunology, biochemistry, as well as molecular medicine and dentistry.


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Microbial adhesion and invasion
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ISBN: 0387978151 Year: 1992 Publisher: New York (N.Y.) : Springer,

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Phagocytosis : microbial invasion
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ISBN: 1281060135 9786611060138 008052608X 0762306106 9780762306107 9780080526089 9781281060136 6611060138 Year: 1999 Publisher: Stamford, CT : JAI Press,

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The present volume focuses on microbial invasion strategies of pathogen uptake. An accompanying volume (Vol. 5) in the series presents the phagocytic process from the viewpoint of the host cell. This field of study is growing rapidly after a somewhat slow start over recent decades. This collection of invited chapters attempts to reflect current research and brings together cell biologists, microbiologists, and immunologists with disthemes, hopefully like a symphony rather than a boring catalogue. It will be evident that editorial bias favors intracellular parasitism and medically important


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Current Trends in Immunity and Respiratory Infections
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ISBN: 3030016358 303001634X Year: 2018 Publisher: Cham : Springer International Publishing : Imprint: Springer,

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The purpose of this book is to disseminate and deliberate on the latest knowledge concerning immunity and its role in protection and fight against microorganism invasion. The articles tackle both humoral and cellular immunity, and their interconnectivity. The former involves B cells that recognize invading pathogens and create the antibody-mediated response, which when memorized provides future immunity. The latter involves mostly T cells, exemplified by cytotoxic or killer cell destroying the pathogens, or helper cells stimulating B cells to produce antibodies to bind and neutralize the pathogens. T cells act through release of cytokines, interleukins, and other bioactive mediators. Neutrophils play a key role in innate immunity against bacterial infections. The process of NETosis is a recently unraveled sophisticated defense mechanism, consisting of the formation of neutrophil extracellular traps that catch, immobilize, and remove pathogens from the body. Dysfunction of immunity is indisputably conducive to the propensity for infections, particularly respiratory tract infections, as the airways are the first line of defense against invading pathogens. Pathogens can rapidly evolve and adapt to avoid detection by the immune system. The case in point is the influenza virus. The articles report on the epidemiology, diagnostics, serology, complications, and the process of acquired immunity due to vaccination against influenza and influenza-like infections in recent epidemic seasons. The book is a blend of medical research and practice. It is intended for academic scientists, research scholars, clinicians, family doctors, and healthcare professionals.

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