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Book
Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

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Abstract

Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Keywords

Metal ions.


Book
Metal ions in aqueous solution
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Year: 1963 Publisher: New York, N.Y.: Benjamin,

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Book
Studies on the state and function of metal ions in carbonic anhydrase.
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Year: 1968 Publisher: Göteborg : Stockholm : Universitetet; Almqvist & Wiksell (distr.),

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Book
Metal-ion separation and preconcentration : progress and opportunities
Authors: --- --- ---
ISBN: 0841217041 Year: 1999 Publisher: Washington, DC : American Chemical Society,

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Keywords

Metal ions --- Separation


Book
Microbiology of metal ions
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ISBN: 0128123877 0128123869 Year: 2017 Publisher: Oxford, [England] : Elsevier,

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Keywords

Metal ions. --- Metals --- Microbiology.


Book
Compilation of rate constants for the reactions of metal ions in unusual valency states
Authors: --- ---
Year: 1978 Publisher: Washington : U.S. Dept. of Commerce, National Bureau of Standards,

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Book
Biosorption and bioaccumulation in practice
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ISBN: 9781604569391 1604569395 Year: 2009 Publisher: New York: Nova Science,

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Book
Crystal fields for transition-metal ions in laser host materials
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ISBN: 0387554653 3540554653 Year: 1992 Publisher: Berlin Springer

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Book
Insertion of guest molecules into a mixed ligand metal-organic framework via single-crystal-to-single-crystal guest exchange
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Year: 2014 Publisher: Aberdeen Proving Ground, MD : Army Research Laboratory,

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Concepts on metal ion toxicity
Authors: ---
ISBN: 0824775406 Year: 1986 Volume: v. 20 Publisher: New York : Dekker,

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