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CARBOHYDRATES --- Carbohydrate Metabolism. --- Metabolism, Carbohydrate --- Carbohydrate metabolism. --- Carbohydrates. --- Carbohydrate metabolism --- Carbohydrates --- Carbs (Carbohydrates) --- Biomolecules --- Organic compounds --- Glycomics --- Carbohydrate --- metabolism --- Metabolism. --- Carbohydrate Metabolism --- Carbohydrates - metabolism
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Glyco-engineering is being developed as a method to control the composition of carbohydrates and to enhance the pharmacological properties of monoclonal antibodies (mAbs) and other proteins. In Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols, experts in the field provide readers with production and characterization protocols of glycoproteins and glyco-engineered biopharmaceuticals with a focus on mAbs. The volume is divided in four complementary parts dealing with glyco-engineering of therapeutic proteins, glycoanalytics, glycoprotein complexes characterization, and PK/PD assays for therapeutic antibodies. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glycosylation Engineering of Biopharmaceuticals: Methods and Protocols serves as an ideal guide for scientists striving to push forward the exciting field of engineered biopharmaceuticals.
Pharmaceutical biotechnology --- Glycosylation --- Biopharmaceutics --- Glycoconjugates --- Investigative Techniques --- Pharmacology --- Carbohydrate Metabolism --- Antibodies --- Biological Science Disciplines --- Carbohydrates --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Biochemical Processes --- Immunoglobulins --- Natural Science Disciplines --- Biochemical Phenomena --- Chemicals and Drugs --- Immunoproteins --- Blood Proteins --- Chemical Phenomena --- Disciplines and Occupations --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Methods --- Glycoproteins --- Antibodies, Monoclonal --- Health & Biological Sciences --- Pharmacy, Therapeutics, & Pharmacology --- Glycosylation. --- Pharmaceutical biotechnology. --- Biopharmaceutics. --- Biotechnologie pharmaceutique --- Biopharmacie --- therapeutic use. --- methods. --- Monoclonal Antibodies --- Protein Glycosylation --- Glycosylation, Protein --- Glycosylations --- Glycosylations, Protein --- Protein Glycosylations --- Glycoprotein --- Neoglycoproteins --- Methodological Studies --- Methodological Study --- Procedures --- Studies, Methodological --- Study, Methodological --- Method --- Procedure --- Gene Products, Protein --- Gene Proteins --- Protein Gene Products --- Proteins, Gene --- Chemical Phenomenon --- Chemical Process --- Physical Chemistry Phenomena --- Physical Chemistry Process --- Physicochemical Phenomenon --- Physicochemical Process --- Chemical Concepts --- Chemical Processes --- Physical Chemistry Concepts --- Physical Chemistry Processes --- Physicochemical Concepts --- Physicochemical Phenomena --- Physicochemical Processes --- Chemical Concept --- Chemistry Process, Physical --- Chemistry Processes, Physical --- Concept, Chemical --- Concept, Physical Chemistry --- Concept, Physicochemical --- Concepts, Chemical --- Concepts, Physical Chemistry --- Concepts, Physicochemical --- Phenomena, Chemical --- Phenomena, Physical Chemistry --- Phenomena, Physicochemical --- Phenomenon, Chemical --- Phenomenon, Physicochemical --- Physical Chemistry Concept --- Physicochemical Concept --- Process, Chemical --- Process, Physical Chemistry --- Process, Physicochemical --- Processes, Chemical --- Processes, Physical Chemistry --- Processes, Physicochemical --- Plasma Proteins --- Serum Proteins --- Proteins, Blood --- Proteins, Plasma --- Proteins, Serum --- Biochemical Concepts --- Biochemical Phenomenon --- Biochemical Process --- Phenomena, Biochemical --- Biochemical Concept --- Concept, Biochemical --- Concepts, Biochemical --- Phenomenon, Biochemical --- Process, Biochemical --- Processes, Biochemical --- Natural Sciences --- Physical Sciences --- Discipline, Natural Science --- Disciplines, Natural Science --- Natural Science --- Natural Science Discipline --- Physical Science --- Science, Natural --- Science, Physical --- Sciences, Natural --- Sciences, Physical --- Immunoglobulin --- Globulins, Immune --- Immune Globulins --- Carbohydrate --- Biologic Sciences --- Biological Science --- Science, Biological --- Sciences, Biological --- Biological Sciences --- Life Sciences --- Biologic Science --- Biological Science Discipline --- Discipline, Biological Science --- Disciplines, Biological Science --- Life Science --- Science Discipline, Biological --- Science Disciplines, Biological --- Science, Biologic --- Science, Life --- Sciences, Biologic --- Sciences, Life --- Metabolism, Carbohydrate --- Pharmacologies --- Pharmaceutical Preparations --- Investigative Technics --- Investigative Technic --- Investigative Technique --- Technic, Investigative --- Technics, Investigative --- Technique, Investigative --- Techniques, Investigative --- Glycation --- Biopharmaceutical technology --- Drugs --- blood --- metabolism --- pharmacology --- Biotechnology --- Medicine. --- Pharmacology. --- Biochemical engineering. --- Biomedicine. --- Pharmacology/Toxicology. --- Biochemical Engineering. --- Bio-process engineering --- Bioprocess engineering --- Biochemistry --- Chemical engineering --- Drug effects --- Medical pharmacology --- Medical sciences --- Chemicals --- Chemotherapy --- Pharmacy --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Pathology --- Physicians --- Physiological effect --- Toxicology. --- Medicine --- Poisoning --- Poisons --- Toxicology
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Biomembranes --- Hormone receptors --- Membrane proteins --- Energy transfer --- Energy metabolism --- Receptors, Cell Surface --- Membrane Proteins --- Energy Transfer --- Congresses --- 577.112 --- Energy Transfer. --- Membrane Proteins. --- Receptors, Cell Surface. --- -Energy transfer --- -Hormone receptors --- -Membrane proteins --- -Membranes (Biology) --- Proteins --- Hormones --- Receptors, Hormone --- Cell receptors --- Energy storage --- Force and energy --- Transport theory --- Bioenergetics --- Metabolism --- Microbial respiration --- Cell Surface Hormone Receptors --- Endogenous Substances Receptors --- Cell Surface Receptors --- Hormone Receptors, Cell Surface --- Receptors, Endogenous Substances --- Binding Sites --- Ligands --- Receptor Cross-Talk --- Integral Membrane Protein --- Membrane Protein --- Membrane-Associated Proteins --- Cell Membrane Proteins --- Cell Surface Proteins --- Integral Membrane Proteins --- Surface Proteins --- Membrane Associated Proteins --- Membrane Protein, Integral --- Membrane Proteins, Integral --- Protein, Integral Membrane --- Protein, Membrane --- Proteins, Cell Membrane --- Proteins, Cell Surface --- Proteins, Integral Membrane --- Proteins, Membrane --- Proteins, Membrane-Associated --- Proteins, Surface --- Cell Membrane --- Membranes --- Transfer, Energy --- Receptors --- Conferences - Meetings --- 577.218 --- Gene expression --- -Genes --- Genetic regulation --- Molecular mechanisms of control : gene expression. Molecular embryology --- Expression --- 577.152.1 --- Oxidases --- -Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.112.824 --- Albumin --- -Albumen --- Albumins --- Carbohydrate Metabolism. --- Carbohydrate metabolism --- -Metabolism --- -577.124 --- Anabolism --- Catabolism --- Metabolism, Primary --- Primary metabolism --- Biochemistry --- Physiology --- Metabolism, Carbohydrate --- Carbohydrates --- Regulation --- -Congresses --- metabolism --- 577.175.322 --- Cells --- -Growth --- -Growth regulators --- -Growth regulating substances --- Morphology (Animals) --- Developmental biology --- Organisms --- Cytology --- Growth hormone. Somatotrophic hormone --- Growth --- Fatty Acids --- 577.125 --- Glycerides --- Fatty acids --- -Glycerides --- -Acids, Fatty --- Carboxylic acids --- metabolism. --- Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Protease Inhibitors. --- Peptide Hydrolases --- 577.152.34 --- 612.321 --- Protease inhibitors --- Proteolytic enzymes --- -Peptide hydrolases --- Proteases --- Hydrolases --- Proteolytic enzyme inhibitors --- Enzyme inhibitors --- Antiproteases --- Protease Inhibitor --- Endopeptidase Inhibitors --- Peptidase Inhibitors --- Peptide Hydrolase Inhibitors --- Peptide Peptidohydrolase Inhibitors --- Protease Antagonists --- Antagonists, Protease --- Hydrolase Inhibitors, Peptide --- Inhibitor, Protease --- Inhibitors, Endopeptidase --- Inhibitors, Peptidase --- Inhibitors, Peptide Hydrolase --- Inhibitors, Peptide Peptidohydrolase --- Inhibitors, Protease --- Peptidohydrolase Inhibitors, Peptide --- Endopeptidases --- Exopeptidases --- Proteinase Inhibitory Proteins, Secretory --- Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- Inhibitors --- antagonists & inhibitors --- -Growth hormone. Somatotrophic hormone --- -metabolism. --- -Proteins --- -Molecular mechanisms of control : gene expression. Molecular embryology --- -Albumins --- -577.152.1 Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- Oxidoreductases. Oxidases. Dehydrogenases. Reductases etc. --- 577.175.322 Growth hormone. Somatotrophic hormone --- 612.321 Normal composition of gastric juice. Pepsin. Proteolytic enzymes --- 577.152.34 Acting on peptide bonds (peptide hydrolases), proteolytic fermentation. Proteinases --- 577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- -577.112 Proteins --- Membranes (Biology) --- 577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- 577.124 Carbohydrate metabolism --- 612.398 --- -Proteins in human nutrition --- -Nutrition --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- 612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- 577.112 Proteins --- -612.398 Proteins, nitrogenous foodstuffs. Albumin. Albuminoids. Proteolysis --- -577.125 Lipid metabolism. Lipoid metabolism. Fatty-acid metabolism --- Acids, Fatty --- -577.175.322 Growth hormone. Somatotrophic hormone --- Growth regulating substances --- -577.218 Molecular mechanisms of control : gene expression. Molecular embryology --- Genes --- -Proteolytic enzyme inhibitors --- Peptide hydrolases --- Nutrition --- Antiprotease --- Endopeptidase Inhibitor --- Peptidase Inhibitor --- Peptide Hydrolase Inhibitor --- Peptide Peptidohydrolase Inhibitor --- Protease Antagonist --- Antagonist, Protease --- Hydrolase Inhibitor, Peptide --- Inhibitor, Endopeptidase --- Inhibitor, Peptidase --- Inhibitor, Peptide Hydrolase --- Inhibitor, Peptide Peptidohydrolase --- Peptidohydrolase Inhibitor, Peptide --- Cell Surface Receptor --- Receptor, Cell Surface --- Surface Receptor, Cell --- Cell Membrane Protein --- Cell Surface Protein --- Membrane-Associated Protein --- Surface Protein --- Membrane Associated Protein --- Membrane Protein, Cell --- Protein, Cell Membrane --- Protein, Cell Surface --- Protein, Membrane-Associated --- Protein, Surface --- Surface Protein, Cell --- Protease Inhibitors --- Carbohydrate Metabolism --- -metabolism --- Hormone receptors - Congresses --- Membrane proteins - Congresses --- Energy transfer - Congresses --- Energy metabolism - Congresses --- Receptors, Cell Surface - congresses --- Membrane Proteins - congresses --- Energy Transfer - congresses --- -Transfer, Energy
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