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Mesotheliomas are mysterious mesothelial tumors in that they are relatively rare, difficult to diagnose, with a large number of synonyms, and the etiology and pathogenesis of the disease are still not fully disclosed. This problem attracts the attention of various specialists in the field of medicine and biology every year. In recent years there has been a significant increase of mesothelioma morbidity in most of the countries, due to the further industrialization of society. In this regard, this book has been published with the participation of an international group of experts with rich experience from around the world . The book consists of 14 chapters containing the most advanced achievements of all aspects of the various types of mesotheliomas, both in humans and domestic animals, at a high methodological level. This book is intended for biologists and all health care workers, mostly oncologists of different profiles, as well as students of medical educational institutions engaged or even just interested in the problems of mesotheliomas.

Mesothelioma. --- Mesothelium --- Tumors --- Oncology

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The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers.

Mesothelium --- Serosal Membranes --- Physiology --- Pleura --- Peritoneum --- Pericardium

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The mesothelium is composed by a single layer of mesothelial cells that vest the serosal cavities (pleural, peritoneal and pericardial) and internal organs of the body. The mesothelial cells have a mixed phenotype of epithelial cells and fibroblasts rendering them remarkable plasticity. Besides providing a slippery surface for the frictionless movement of internal organs, the mesothelium participates in a wide range of physiological and pathophysiological processes. Some of its functions include lung development, trans-cellular and para-cellular transport of ions and water, secretion of glycoproteins (mainly hyaluronan), secretion of cytokines and growth factors, wound healing, response to inflammatory stimuli and induction of inflammation, mesothelial to mesenchymal transition and formation of tunneling nanotubes. Many of these functions are pivotal to physiological conditions such as respiratory development, maintenance of steady volume of serosal fluids and serosal permeability, cell-to-cell communication, re-mesotheliazation of serosal membranes after mechanical (e.g. by asbestos or nanoparticles) or inflammatory injury and participation in immune responses. Deviation from the physiological threshold of these functions results in the development of serosal effusions, induction of serosal and lung fibrosis, induction of mesothelial tumorigenesis, leading thus to devastating pathologies. Treatment of pathologies like mesothelioma, pleural and peritoneal fibrosis (in cases of patients under Peritoneal Dialysis) or lung fibrosis still pose a great challenge for researchers.

Mesothelium --- Serosal Membranes --- Physiology --- Pleura --- Peritoneum --- Pericardium

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This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma. Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included. Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases. Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance. Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

Medicine. --- Cancer research. --- Biomedicine. --- Cancer Research. --- Mesothelioma. --- Lungs --- Diseases. --- Mesothelium --- Tumors --- Pulmonary diseases --- Oncology. --- Cancer research --- Cancer --- Research.

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This book encompasses all areas for mesothelioma care, treatment, and research. Using nurses, social workers, surgeons, oncologist, radiologist and pain specialist to give the reader a comprehensive overview of mesothelioma treatment. Indeed, mesothelioma is a cancer that mainly affects the pleura and peritoneum, usually caused by exposure to asbestos. The number of individuals diagnosed with mesothelioma is increasing world-wide, particularly in developing countries where the use of asbestos remains uncontrolled. In spite of advances in chemotherapy, radiotherapy, and surgical approaches, mesothelioma remains resistant to treatment. According to the International Mesothelioma Interest group, overall survival has not improved; median survival times vary from one month to eighteen months. A small number of patients remain asymptomatic or with minimal symptoms for extended periods, and fewer live three years or more. Mesothelioma is often associated with difficult, intractable symptoms, particularly pain and difficulty breathing. Especially poor prognoses have been reported for those diagnosed with sarcomatoid rather than epithelioid histology, or with advanced disease, poor performance status, or pain and loss of appetite. Despite substantial progress of the last two decades improving the quality of life of patients with cancer, many mesothelioma patients still experience physical, psychological, social, and financial burdens. The development of multimodality treatment and mesothelioma centers has given renewed hope to patients. This book serves as a unique tool for medical professional while providing care for mesothelioma patients.

Mesothelioma. --- Mesothelium --- Tumors --- Nursing. --- Oncology  . --- Pneumology. --- Oncology. --- Pneumology/Respiratory System. --- Clinical nursing --- Nurses and nursing --- Nursing process --- Care of the sick --- Medicine --- Respiratory organs—Diseases.