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With the thorough understanding of stem cell biology and the advent of targeted therapeutics for cancer, stem cell-based therapeutic strategies are being increasingly explored for the treatment of various cancer types. The aim of this publication is to shed light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells (MSC) in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies for cancer. Different sections of this publication will be devoted to developing stem c

Mesenchymal stem cells. --- Cancer --- Treatment. --- Neoplasms --- Mesenchymal Stem Cell Transplantation. --- Mesenchymal Stem Cells --- physiology. --- Transplantation, Mesenchymal Stem Cell --- Stem Cell Transplantation, Mesenchymal --- Cancer therapy --- Cancer treatment --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- transplantation --- Therapy --- Stem cells.

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Stem Cells and COVID-19 presents up-to-date knowledge on the effect of hematopoietic and mesenchymal stem cells to combat SARS-CoV-2 infection in its diagnosis, treatment and prevention. In addition, the book critically discusses challenges, highlighting outstanding questions and future perspectives. Written by global experts in the field for both pre-clinical and clinical practitioners, this comprehensive book delves into how stem cells have a strong potential in developing better diagnostic, treatment and preventive strategies in SARS-CoV-2 infection. Both hematopoietic and mesenchymal stem cells are critical to better understand the response of immune system to coronavirus infection in both healthy and co-morbid conditions in the development of effective vaccines and immunotherapies.

COVID-19 (Disease) --- Stem cells --- 2019-nCoV disease --- 2019 novel coronavirus disease --- Coronavirus disease-19 --- Coronavirus disease 2019 --- COVID-19 virus disease --- COVID19 (Disease) --- Novel coronavirus disease, 2019 --- SARS coronavirus 2 disease --- SARS-CoV-2 disease --- Coronavirus infections --- Respiratory infections --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Prevention. --- Treatment. --- Therapeutic use. --- COVID-19 --- Hematopoietic Stem Cell Transplantation --- Mesenchymal Stem Cell Transplantation --- therapy --- prevention & control

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The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.

Medicine --- MPC polymer --- dry eye --- ocular surface --- lacrimal fluid --- mucin --- 3D bioprinting --- cornea --- retina --- ophthalmology --- tissue regeneration --- electrospinning --- conjunctiva --- decellularized tissue matrix --- small intestinal submucosa --- urinary bladder matrix --- polycaprolactone --- fiber --- tissue engineering --- stratification --- conjunctival epithelial cells --- hydrogel --- keratoplasty --- scaffold --- collagen --- advanced therapy medicinal product --- ATMP --- cell therapy --- gene therapy --- eye --- ocular --- regulatory --- marketing authorization --- double-crosslinking --- carbodiimide --- glutaraldehyde --- sodium metabisulfite --- sodium borohydride --- EDC/NHS --- stem cells --- retinal diseases --- optic nerve diseases --- cell replacement --- cell sources --- advanced therapies --- ocular mucosa --- blindness --- CLET --- limbal niche --- limbal stem cell --- LSCD --- mesenchymal stem cell transplantation --- MSCT --- corneal limbus --- decellularized xenograft --- recellularization --- mesenchymal stem cells --- MPC polymer --- dry eye --- ocular surface --- lacrimal fluid --- mucin --- 3D bioprinting --- cornea --- retina --- ophthalmology --- tissue regeneration --- electrospinning --- conjunctiva --- decellularized tissue matrix --- small intestinal submucosa --- urinary bladder matrix --- polycaprolactone --- fiber --- tissue engineering --- stratification --- conjunctival epithelial cells --- hydrogel --- keratoplasty --- scaffold --- collagen --- advanced therapy medicinal product --- ATMP --- cell therapy --- gene therapy --- eye --- ocular --- regulatory --- marketing authorization --- double-crosslinking --- carbodiimide --- glutaraldehyde --- sodium metabisulfite --- sodium borohydride --- EDC/NHS --- stem cells --- retinal diseases --- optic nerve diseases --- cell replacement --- cell sources --- advanced therapies --- ocular mucosa --- blindness --- CLET --- limbal niche --- limbal stem cell --- LSCD --- mesenchymal stem cell transplantation --- MSCT --- corneal limbus --- decellularized xenograft --- recellularization --- mesenchymal stem cells

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Current Topics in iPSCs provides a deep analysis of the underlying fundamentals that support short and mid-term developments and milestones in the business of mesenchymal stem cell therapies. This volume explores the next frontier of MSC therapies and how the transformational potential of therapeutic adult cells will be realised in all therapy areas. The impacts of clinical and economic benefits are dissected throughout each of the chapters. Written by thought leaders in the field for those curious about the interface of science and business.

Mesenchymal stem cells. --- Stem cells --- Mesenchymal Stem Cells. --- Stem Cells. --- Stem Cell Research. --- Adult Stem Cell Research --- Embryonic Stem Cell Research --- Research, Stem Cell --- Researchs, Stem Cell --- Stem Cell Researchs --- Stem Cells --- Embryo Research --- Colony-Forming Unit --- Colony-Forming Units --- Mother Cells --- Progenitor Cells --- Cell, Mother --- Cell, Progenitor --- Cell, Stem --- Cells, Mother --- Cells, Progenitor --- Cells, Stem --- Colony Forming Unit --- Colony Forming Units --- Mother Cell --- Progenitor Cell --- Stem Cell --- Cell Self Renewal --- Stem Cell Research --- Colony-forming units (Cells) --- Mother cells --- Progenitor cells --- Cells --- Bone marrow stromal cells --- Marrow stromal cells --- MSCs (Mesenchymal stem cells) --- Stromal cells, Bone marrow --- Stromal cells, Marrow --- Multipotent stem cells --- Therapeutic use. --- Adipose Tissue-Derived Mesenchymal Stem Cells --- Adipose Tissue-Derived Mesenchymal Stromal Cells --- Adipose-Derived Mesenchymal Stem Cells --- Adipose-Derived Mesenchymal Stromal Cells --- Bone Marrow Mesenchymal Stem Cells --- Bone Marrow Stromal Cell --- Bone Marrow Stromal Cells --- Bone Marrow Stromal Cells, Multipotent --- Bone Marrow Stromal Stem Cells --- Mesenchymal Progenitor Cell --- Mesenchymal Progenitor Cells --- Mesenchymal Stem Cell --- Mesenchymal Stem Cells, Adipose-Derived --- Mesenchymal Stromal Cells, Multipotent --- Multipotent Bone Marrow Stromal Cells --- Multipotent Mesenchymal Stromal Cells --- Stem Cells, Mesenchymal --- Wharton Jelly Cells --- Wharton's Jelly Cells --- Adipose Tissue-Derived Mesenchymal Stem Cell --- Adipose-Derived Mesenchymal Stem Cell --- Bone Marrow Mesenchymal Stem Cell --- Mesenchymal Stromal Cell --- Mesenchymal Stromal Cells --- Multipotent Bone Marrow Stromal Cell --- Multipotent Mesenchymal Stromal Cell --- Adipose Derived Mesenchymal Stem Cell --- Adipose Derived Mesenchymal Stem Cells --- Adipose Derived Mesenchymal Stromal Cells --- Adipose Tissue Derived Mesenchymal Stem Cell --- Adipose Tissue Derived Mesenchymal Stem Cells --- Adipose Tissue Derived Mesenchymal Stromal Cells --- Mesenchymal Stem Cells, Adipose Derived --- Progenitor Cell, Mesenchymal --- Progenitor Cells, Mesenchymal --- Stem Cell, Mesenchymal --- Stromal Cell, Mesenchymal --- Stromal Cells, Mesenchymal --- Wharton's Jelly Cell --- Whartons Jelly Cells --- Induced pluripotent stem cells. --- Induced pluripotent stem cells --- Induced Pluripotent Stem Cells --- Mesenchymal Stem Cells --- Mesenchymal Stem Cell Transplantation