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Sickle cell anemia --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Treatment.
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This book presents a comprehensive overview of sickle cell anemia, with chapters addressing diagnosis and clinical, psychosocial, and pharmacological management of patients with this disease. It is a vital resource for biomedical science and medical students, interns, pediatricians, general physicians, and other healthcare professionals involved in offering care and support to patients with sickle cell disease.
Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia
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This book addresses a wide range of clinically relevant topics and issues in sickle cell disease. This is written by experts in their own field offering a robust, engaging discussion about the presentations and mechanisms of actions in the multiple complications associated with sickle cell disease. This first of the series addresses pain, which is considered the hallmark of sickle cell presentation. It looks at the basic mechanism of pain in sickle cell disease. A more detailed review of precision medicine gives a clear well laid out presentation that is incisive and yet gives in-depth detail relevant to both the clinician and the researcher in the basic laboratory. The same pattern is shown in the discussion on respiratory, cardiac and neurological complications. The 14 chapters also include an overview of sickle cell disease especially in the paediatric age. The content is organized into well-designed broad sections on overview regarding diagnosis including point of care and the role of digital apps in patient management. A key aspect of the book is the opportunity it affords expert physicians to express well-reasoned opinions regarding complex issues in sickle cell disease. The readership would find that it provides a well-described, concise and immediate applicable answers to complex questions. This is highly recommended for scientists and clinicians alike.
Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Medicine --- Hematology --- Hematopathology --- Health Sciences
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Sickle cell anemia. --- Hemolytic anemia. --- Anemia --- Hemolysis and hemolysins --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia
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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts. .
Medicine. --- Hematology. --- Medicine & Public Health. --- Haematology --- Clinical sciences --- Medical profession --- Sickle cell anemia --- Hematopoietic stem cells --- Treatment. --- Transplantation. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Internal medicine --- Blood --- Diseases
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This practical clinical handbook reveals that sickle cell disease (SCD) is an increasingly common condition to manage in Europe and North America. SCD demands clinical expertise and experience as well as sensitivity to its social and cultural context. This book is designed to broaden readers’ knowledge in this challenging condition by describing the acute and long-term complications unique to SCD and that affect nearly every system of the body. Critically, it also details the significant recent advances in understanding the pathophysiology of SCD that are leading to novel treatment modalities. Sickle Cell Disease in Clinical Practice promotes higher quality care by outlining the clinical problems as they arise, and covering essential background information, including up-to-date research, and useful points to guide management. As such, the intended target audience is broad and includes general physicians, general practitioners, hematologists, pediatricians, emergency medicine physicians, surgeons, medical students, nurse specialists and commissioners.
Medicine & Public Health. --- Hematology. --- Pathology. --- Blood Transfusion Medicine. --- Medicine. --- Blood transfusion. --- Médecine --- Hématologie --- Pathologie --- Medicine --- Health & Biological Sciences --- Pathology --- Sickle cell anemia. --- Clinical medicine. --- Medicine, Clinical --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Blood transfusion --- Blood transfusion therapy --- Hemotherapy --- Transfusion medicine --- Transfusion of blood --- Transfusion therapy --- Transfusion therapy, Blood --- Surgery --- Blood banks --- Blood groups --- Hospitals --- Transfusion-free surgery --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Haematology --- Internal medicine --- Blood --- Transfusion committees
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Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
Pathology --- Medicine --- Health & Biological Sciences --- Sickle cell anemia. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Hematology. --- Internal medicine. --- Biochemistry. --- Medicine. --- Internal Medicine. --- Medical Biochemistry. --- Medicine/Public Health, general. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medicine, Internal --- Haematology --- Internal medicine --- Blood --- Composition --- Diseases --- Health Workforce --- Medical biochemistry. --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry
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This book is a wide-ranging guide to the diagnosis and management of the numerous medical and surgical complications that may arise in patients with sickle cell anemia. After introductory chapters on the genetics, pathophysiology, clinical features, and variants of sickle cell anemia, the complications observed in different parts of the body are addressed in a series of well-illustrated chapters. The coverage includes splenic, hepatobiliary, musculoskeletal, gastrointestinal, ophthalmological, cardio- and cerebrovascular, and renal complications, as well as acute chest syndrome, leg ulcers, hand and foot syndrome, acute appendicitis, and priapism. Treatment-oriented chapters consider perioperative management, blood transfusion therapy, hydroxyurea treatment, hematopoietic stem cell transplantation, and emerging strategies. The book is clearly written in a distinctive bullet point format for ease of reference and emphasizes especially aspects of practical significance. It will be of value for hematologists, general surgeons, internists, pediatricians, pediatric surgeons, fellows, residents, medical students, and nurses.
Anemia, Sickle Cell --- History, 20th Century --- Anemia, Hemolytic, Congenital --- History, Modern 1601 --- -Hemoglobinopathies --- Genetic Diseases, Inborn --- History --- Hematologic Diseases --- Anemia, Hemolytic --- Anemia --- Congenital, Hereditary, and Neonatal Diseases and Abnormalities --- Hemic and Lymphatic Diseases --- Humanities --- Diseases --- Pathology --- Medicine --- Health & Biological Sciences --- Sickle cell anemia --- Complications. --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Hematology. --- Surgery. --- Biochemistry. --- Pediatric Surgery. --- Medical Biochemistry. --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Biology --- Chemistry --- Medical sciences --- Surgery, Primitive --- Haematology --- Internal medicine --- Blood --- Composition --- Pediatric surgery. --- Medical biochemistry. --- Pediatric surgery --- Surgery, Pediatric --- Children --- Medical biochemistry --- Pathobiochemistry --- Pathological biochemistry --- Biochemistry --- Treatment
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On average, black Americans are sicker and die earlier than white Americans. Uncertain Suffering provides a richly nuanced examination of what this fact means for health care in the United States through the lens of sickle cell anemia, a disease that primarily affects blacks. In a wide ranging analysis that moves from individual patient cases to the compassionate yet distanced professionalism of health care specialists to the level of national policy, Carolyn Moxley Rouse uncovers the cultural assumptions that shape the quality and delivery of care for sickle cell patients. She reveals a clinical world fraught with uncertainties over how to treat black patients given resource limitations and ambivalence. Her book is a compelling look at the ways in which the politics of racism, attitudes toward pain and suffering, and the reliance on charity for healthcare services for the underclass can create disparities in the U.S. Instead of burdening hospitals and clinics with the task of ameliorating these disparities, Rouse argues that resources should be redirected to community-based health programs that reduce daily forms of physical and mental suffering.
Sickle cell anemia --- Discrimination in medical care --- Health services accessibility --- Minorities --- Race discrimination --- Social medicine --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Patients --- Medical care --- african americans. --- ambivalence. --- american healthcare system. --- anthropology. --- black americans. --- community based health programs. --- cultural assumptions. --- disease. --- doctor. --- health disparity. --- healthcare services. --- healthcare. --- human condition. --- life and death. --- medical treatment. --- medicine. --- mental suffering. --- national policy. --- pain and suffering. --- physical suffering. --- politics of racism. --- race in america. --- resource limitations. --- sicker. --- sickle cell anemia. --- sickle cell patients. --- sickness. --- symptoms. --- united states of america. --- wealth disparity.
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Why do racial and ethnic controversies become attached, as they often do, to discussions of modern genetics? How do theories about genetic difference become entangled with political debates about cultural and group differences in America? Such issues are a conspicuous part of the histories of three hereditary diseases: Tay-Sachs, commonly identified with Jewish Americans; cystic fibrosis, often labeled a "Caucasian" disease; and sickle cell disease, widely associated with African Americans. In this captivating account, historians Keith Wailoo and Stephen Pemberton reveal how these diseases -- fraught with ethnic and racial meanings for many Americans -- became objects of biological fascination and crucibles of social debate. Peering behind the headlines of breakthrough treatments and coming cures, they tell a complex story: about different kinds of suffering and faith, about unequal access to the promises and perils of modern medicine, and about how Americans consume innovation and how they come to believe in, or resist, the notion of imminent medical breakthroughs. With Tay-Sachs, cystic fibrosis, and sickle cell disease as a powerful backdrop, the authors provide a glimpse into a diverse America where racial ideologies, cultural politics, and conflicting beliefs about the power of genetics shape disparate health care expectations and experiences.&
Genetic disorders --- Ethnic groups --- Tay-Sachs disease --- Cystic fibrosis --- Sickle cell anemia --- Research --- Moral and ethical aspects --- Diseases --- Genetic aspects --- Genetic Diseases, Inborn --- Anemia, Sickle Cell. --- Cystic Fibrosis. --- Health Services Accessibility. --- Tay-Sachs Disease. --- #SBIB:316.334.3M11 --- #SBIB:316.334.3M51 --- Amaurotic familial idiocy --- Amaurotic family idiocy --- Gangliosidosis GM2 type 1 --- GM2 gangliosidosis, Type 1 --- Hexosaminidase A deficiency (Tay-Sachs) --- Sachs disease --- Type 1 GM2 gangliosidosis --- Gangliosidoses --- Access to health care --- Accessibility of health services --- Availability of health services --- Medical care --- CF (Disease) --- Fibrocystic disease of pancreas --- Mucoviscidosis --- Pancreatic cystic fibrosis --- Fibrosis --- Lungs --- Pancreas --- Drepanocytic anemia --- Meniscocytosis --- Sickle cell disease --- Blood hyperviscosity syndrome --- Hemoglobinopathy --- Hemolytic anemia --- Ethnic identities --- Ethnic nations (Ethnic groups) --- Groups, Ethnic --- Kindred groups (Ethnic groups) --- Nationalities (Ethnic groups) --- Peoples (Ethnic groups) --- Ethnology --- Congenital diseases --- Disorders, Genetic --- Disorders, Inherited --- Genetic diseases --- Hereditary diseases --- Inherited diseases --- Medical genetics --- Moral and ethical aspects. --- Diseases. --- Genetic aspects. --- ethnology. --- prevention & control. --- Medische sociologie: concepten en theorieën --- Organisatie van de gezondheidszorg: modellen van therapeutisch handelen --- Access --- Ethnology. --- Prevention & control. --- Research&delete& --- Genetic disorders - Research - Moral and ethical aspects --- Ethnic groups - Diseases --- Tay-Sachs disease - Genetic aspects --- Cystic fibrosis - Genetic aspects --- Sickle cell anemia - Genetic aspects --- Droit médical
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