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T-type calcium channels are prevalent in every organ of the body, and are believed to play a part in a variety of physiological processes, including contraction, shape change, secretion, endo- and exocytosis, cell proliferation and differentiation, modulation of enzyme function, and cell cycle progression. As such, research on the roles of these channels in a wide range of diseases has attracted increasing attention in recent years. The purpose of this book is to present a series of unique and comprehensive reviews of our current understanding of T-type calcium channels at the level of the basic sciences as well as the clinical sciences. For key organ systems, information is provided on the correlation between the molecular, biophysical and pharmacological properties of the channels, their cellular mechanisms, and their potential roles in the pathogenesis of various diseases. The compilation presents both commonplace and less well-known findings on these channels in a format designed to appeal to both casual readers and specialists in basic and clinical research on these transporters.

Biomedicine. --- Molecular Medicine. --- Cell Biology. --- Human Physiology. --- Medicine. --- Human physiology. --- Cytology. --- Médecine --- Physiologie humaine --- Cytologie --- Calcium channels --- Membrane Transport Modulators --- Second Messenger Systems --- Calcium Channels --- Molecular Mechanisms of Pharmacological Action --- Ion Channels --- Signal Transduction --- Biochemical Processes --- Membrane Transport Proteins --- Pharmacologic Actions --- Chemical Actions and Uses --- Carrier Proteins --- Biochemical Phenomena --- Proteins --- Chemical Phenomena --- Chemicals and Drugs --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Calcium Channel Blockers --- Calcium Channels, T-Type --- Calcium Signaling --- Biology --- Health & Biological Sciences --- Biophysics --- Physiology --- Pathophysiology --- Calcium channels. --- Research. --- Channels, Calcium --- Molecular biology. --- Cell biology. --- Ion channels --- Human biology --- Medical sciences --- Human body --- Cell biology --- Cellular biology --- Cells --- Cytologists --- Clinical sciences --- Medical profession --- Life sciences --- Pathology --- Physicians --- Health Workforce --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biomolecules --- Systems biology

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Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.

Drugs. --- Ion Channels -- Physiology. --- Ion channels. --- Pharmacology. --- Therapeutics. --- Ion channels --- Molecular Mechanisms of Pharmacological Action --- Membrane Glycoproteins --- Membrane Transport Proteins --- Membrane Proteins --- Pharmacologic Actions --- Carrier Proteins --- Proteins --- Chemical Actions and Uses --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Ion Channels --- Membrane Transport Modulators --- Biology --- Health & Biological Sciences --- Cytology --- Pharmacy, Therapeutics, & Pharmacology --- Channels, Ion --- Chemistry. --- Pharmacy. --- Molecular biology. --- Medicinal chemistry. --- Proteins. --- Medicinal Chemistry. --- Molecular Medicine. --- Protein Science. --- Biological transport, Active --- Ion-permeable membranes --- Membrane proteins --- Biochemistry. --- Medicine. --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Biological chemistry --- Chemical composition of organisms --- Organisms --- Physiological chemistry --- Chemistry --- Medicine --- Drugs --- Materia medica --- Pharmacology --- Composition --- Health Workforce --- Proteins . --- Proteids --- Biomolecules --- Polypeptides --- Proteomics --- Molecular biochemistry --- Molecular biophysics --- Biochemistry --- Biophysics --- Systems biology --- Chemistry, Medical and pharmaceutical --- Chemistry, Pharmaceutical --- Drug chemistry --- Medical chemistry --- Medicinal chemistry --- Pharmacochemistry