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The management of colorectal liver metastases has evolved rapidly over the last decade with the introduction of newer and effective chemotherapies and a redefinition for cure. These range from the philosophical (including the greater awareness of treatment with curative intent), through the practical (more aggressive definition of respectability for cure and the use of more effective chemotherapies for both palliation and as adjuncts to surgery), to the futuristic use of biological strategies (including monoclonal antibodies and gene therapies) and lastly to the pragmatic but equally important issues of health economics (who is going to foot the bill for these increasingly expensive treatment strategies). Liver metastases addresses the contemporary multidisciplinary management of liver metastases. Throughout the text, experience from the paradigms of colorectal cancer metastases treatment strategies are used to point to new directions in the management of liver metastases from other cancers. This book overviews current understanding of the biology of liver metastases, and reviews current methods of detection and diagnosis. Chapters offer objective and systematic reviews of each of the current major treatment modalities: surgical resection; destructive therapies; chemotherapy (systemic and regional); whether there is a role for radiotherapy; biological therapies (including hormone treatment antibodies and gene therapy); and lastly the decision-making strategies that must be employed for successful multidisciplinary management. Featuring state-of-the-art reviews, key points, treatment algorithms and clear, concise illustrations this book provides the ultimate companion to anyone interested or working in the area of liver disease. This book will appeal to consultant and trainee surgeons in general surgery, hepatobiliary surgery, upper GI surgery, colorectal surgery; consultant and trainee medical and clinical oncologists with an interest in liver tumours; and consultant and trainee radiologists with an interest in liver disease.
Liver Neoplasms. --- Neoplasm Metastasis. --- Liver --- Liver metastasis --- Métastases hépatiques --- Cancer
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Neoplasm Metastasis --- Cancer invasiveness --- Metastasis --- Cancer --- Métastases --- physiopathology. --- Caractère envahissant
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Melanoma --- Human skin color --- Lymphatic metastasis --- Mélanome --- Couleur de la peau --- Métastases lymphatiques --- Prognosis --- Pronostic --- EPUB-ETHESIS TPHAR PTHESIS TPHAR
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Neoplasm Metastasis. --- Tissus --- Bone and Bones --- Child. --- Bone metastasis --- Tumors in children --- Cancer in children --- Métastases osseuses --- Tumeurs chez l'enfant --- Cancer chez l'enfant --- pathology --- pathology.
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Oncology. Neoplasms --- Neoplasms --- Medical Oncology --- Neoplasm Metastasis --- Cancer --- Metastasis --- Métastases --- Periodicals --- Periodicals. --- Périodiques --- Métastases --- Neoplasm Metastasis. --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Metastases --- secondary --- Health Sciences --- Clinical Medicine --- Oncology --- Pathology --- Physiology --- Therapeutics --- Metastase
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Nous avons souhaité une nouvelle édition sans refonte complète de cet ouvrage, car le succès de la première édition montre que le principe de ce livre est bien adapté à une prise en charge multidisciplinaire de cette pathologie complexe. L'actualisation des progrès techniques réalisés tant sur le plan diagnostique que thérapeutique était pourtant nécessaire. Deux sujets méritent une attention particulière : la place de l'IRM dans la stratégie diagnostique et thérapeutique et la place de la chirurgie vertébrale dans la stratégie globale de la prise en charge de patients atteints de métastase ve
Spinal Neoplasms --- Bone metastasis --- Spine --- Métastases osseuses --- Colonne vertébrale --- secondary. --- Cancer --- Bone metastasis. --- Cancer. --- Métastases osseuses --- Colonne vertébrale --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B --- Metastatic bone cancer --- Metastatic bone disease --- Osseous metastasis --- Skeletal metastasis --- Bones --- Metastasis
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Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject. One important focus of the book is the efficacy of bisphosphonates in preventing bone metastases in patients with breast, lung, and prostate cancer and disease progression in cases of multiple myeloma. The combined use of bisphosphonates and cytostatics is also discussed, with a report on first clinical data. Further topics addressed include the significance of the bone microenvironment, special issues in the elderly patient, the use of bone turnover markers, and initial findings obtained with denosumab.
Oncology. Neoplasms --- oncologie --- Bone Neoplasms --- Biomarkers. --- Cytostatic Agents --- Diphosphonates --- Bones --- Bone metastasis --- Os --- Métastases osseuses --- prevention & control. --- secondary. --- therapeutic use. --- Cancer --- Prevention --- Prévention --- EPUB-LIV-FT LIVMEDEC SPRINGER-B
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Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria. This book will bring current information on the presentation and management of patients with brain metastases, providing available data, giving guidelines that can be applied in day to day practice, updated information for neuro-surgeons, radiation oncologists, medical oncologists, and neuro-oncologists, as well as an overview for physicians in training. "Brain metastases are one of the most devasting consequences of cancer. This text addresses the epidemiology, pathophysiology, imaging, and management of this complication. Experts in the field cover a broad array of relevant topics highlighting the challenges and current therapeutic strategies." Steven T. Rosen, M.D. Series Editor.
Brain --- Metastasis. --- Cancer. --- Cancer --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Dissemination --- Metastasis --- Oncology . --- Surgical oncology. --- Neurosurgery. --- Oncology. --- Surgical Oncology. --- Nerves --- Neurosurgery --- Oncologic surgery --- Oncological surgery --- Surgical oncology --- Tumors --- Surgery --- Excision --- Treatment --- Nervous system --- Cancer Therapy. --- Treatment. --- Surgery. --- Cancer therapy --- Cancer treatment --- Therapy --- Brain Neoplasms --- Cerveau --- Métastases --- secondary. --- EPUB-LIV-FT LIVMEDEC LIVSANTE SPRINGER-B
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Metastasis --- Neoplasm Metastasis --- Neoplasms --- Medical Oncology --- Métastases --- Benign Neoplasms --- Malignancy --- Neoplasia --- Neoplasm --- Neoplasms, Benign --- Cancer --- Tumors --- Benign Neoplasm --- Cancers --- Malignancies --- Neoplasias --- Neoplasm, Benign --- Tumor --- Cancer metastasis --- Dissemination of cancer --- Metastases --- Metastatic cancer --- Neoplasm metastasis --- Spread of cancer --- Tumor dissemination --- Tumor metastasis --- Tumor spread --- Metastases, Neoplasm --- Metastasis, Neoplasm --- Neoplasm Metastases --- Clinical Oncology --- Oncology, Medical --- Oncology, Clinical --- Dissemination --- secondary --- Malignant Neoplasms --- Malignant Neoplasm --- Neoplasm, Malignant --- Neoplasms, Malignant --- Pathology --- Cancer invasiveness --- Cancer of unknown primary origin --- Metastase --- Neoplasms. --- Medical Oncology. --- Neoplasm Metastasis. --- Métastases --- Metastasis.
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Enzymology --- Oncology. Neoplasms --- Endopeptidases --- Neoplasm Invasiveness --- Metastasis --- Proteinase --- Cancer invasiveness --- Métastases --- Cancer --- Caractère envahissant --- Lymphatic Metastasis. --- Cysteine Proteases. --- Endopeptidases. --- Peptide Peptidohydrolases --- Cysteine Protease --- Cysteine Proteinase --- Cysteine Proteinases --- Protease, Cysteine --- Proteases, Cysteine --- Proteinase, Cysteine --- Proteinases, Cysteine --- Lymphatic Metastases --- Metastases, Lymphatic --- Metastasis, Lymphatic --- Sentinel Lymph Node --- Sentinel Lymph Node Biopsy --- diagnosis. --- Conferences - Meetings --- Métastases --- Caractère envahissant --- Cysteine Proteases --- Lymphatic Metastasis --- Proteolytic enzymes --- Dissemination of cancer --- Invasiveness (Oncology) --- Neoplasm invasiveness --- Spread of cancer --- Tumor dissemination --- Tumor invasiveness --- Tumor progression --- Tumor spread --- Cancer cells --- Congresses --- diagnosis --- Growth --- Lymph Node Metastasis --- Lymph Node Metastases --- Metastasis, Lymph Node --- Endopeptidase
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